公开(公告)号：US6063908A

公开(公告)日：2000-05-16

申请号：US873955

申请日：1997-06-12

申请人： Salvatore Joseph Salamone ,  Stephen S. Vitone ,  Robert Sundoro Wu

发明人： Salvatore Joseph Salamone ,  Stephen S. Vitone ,  Robert Sundoro Wu

IPC分类号： G01N33/53 ,  C07D457/02 ,  C07D457/06 ,  C07D471/06 ,  G01N33/94 ,  C07K17/02

CPC分类号： C07D457/06 ,  C07D471/06 ,  G01N33/94 ,  Y10S530/807

摘要： The present invention provides hapten derivatives that are useful for the preparation of antigens, antibodies and reagents having superior performance characteristics for use in immunoassays for the detection of LSD and nor-LSD. In the present invention the LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. Derivatives have also been synthesized out of the piperidine nitrogen of the LSD nucleus. The resulting haptens can then be further modified at these functionalized positions for linking to appropriate antigenic or labelling groups to provide reagents for LSD immunoassays having excellent sensitivity and selectivity for both LSD and nor-LSD.

公开(公告)号：US06476199B1

公开(公告)日：2002-11-05

申请号：US09502254

申请日：2000-02-17

申请人： Salvatore Joseph Salamone ,  Stephen S. Vitone ,  Robert Sundoro Wu

发明人： Salvatore Joseph Salamone ,  Stephen S. Vitone ,  Robert Sundoro Wu

IPC分类号： C07K1702

CPC分类号： C07D457/06 ,  C07D471/06 ,  G01N33/94 ,  Y10S530/807

摘要： The present invention provides hapten derivatives that are useful for the preparation of antigens, antibodies and reagents having superior performance characteristics for use in immunoassays for the detection of LSD and nor-LSD. In the present invention the LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. Derivatives have also been synthesized out of the piperidine nitrogen of the LSD nucleus. The resulting haptens can then be further modified at these functionalized positions for linking to appropriate antigenic or labelling groups to provide reagents for LSD immunoassays having excellent sensitivity and selectivity for both LSD and nor-LSD.

摘要翻译： 本发明提供了半抗原衍生物，其可用于制备具有优异的性能特征的抗原，抗体和试剂，用于免疫测定用于检测LSD和nor-LSD。 在本发明中，LSD核从吲哚氮中衍生出来形成氨基烷基衍生物。 衍生物也是从LSD核的哌啶氮中合成的。 然后可以在这些官能化位置进一步修饰所得到的半抗原，以连接到合适的抗原或标记基团，为LSD和非LSD具有优异的灵敏度和选择性的LSD免疫测定提供试剂。

公开(公告)号：US5986094A

公开(公告)日：1999-11-16

申请号：US844488

申请日：1997-04-18

申请人： Mitali Ghoshal ,  Salvatore Joseph Salamone ,  Robert Sundoro Wu

发明人： Mitali Ghoshal ,  Salvatore Joseph Salamone ,  Robert Sundoro Wu

IPC分类号： G01N33/542 ,  C07D493/10 ,  G01N21/78 ,  G01N33/533 ,  C07D405/14

CPC分类号： C07D493/10 ,  G01N33/533

摘要： The present invention relates to a novel class of tracer compounds for fluorescence polarization imunoassays. The novel 4'-methyl fluorescein derivatives are conjugated to ligands via cyclic linkers.

摘要翻译： 本发明涉及一类用于荧光偏振免疫测定的示踪剂化合物。 新型4'-甲基荧光素衍生物通过环状连接体与配体缀合。