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    Reagents for lysergic acid diethylamide immunoassay
    2.
    发明授权
    Reagents for lysergic acid diethylamide immunoassay 失效
    麦角酸二乙酰胺免疫测定试剂

    公开(公告)号：US06476199B1

    公开(公告)日：2002-11-05

    申请号：US09502254

    申请日：2000-02-17

    申请人： Salvatore Joseph Salamone ,  Stephen S. Vitone ,  Robert Sundoro Wu

    发明人： Salvatore Joseph Salamone ,  Stephen S. Vitone ,  Robert Sundoro Wu

    IPC分类号： C07K1702

    CPC分类号： C07D457/06 ,  C07D471/06 ,  G01N33/94 ,  Y10S530/807

    摘要： The present invention provides hapten derivatives that are useful for the preparation of antigens, antibodies and reagents having superior performance characteristics for use in immunoassays for the detection of LSD and nor-LSD. In the present invention the LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. Derivatives have also been synthesized out of the piperidine nitrogen of the LSD nucleus. The resulting haptens can then be further modified at these functionalized positions for linking to appropriate antigenic or labelling groups to provide reagents for LSD immunoassays having excellent sensitivity and selectivity for both LSD and nor-LSD.

    摘要翻译： 本发明提供了半抗原衍生物，其可用于制备具有优异的性能特征的抗原，抗体和试剂，用于免疫测定用于检测LSD和nor-LSD。 在本发明中，LSD核从吲哚氮中衍生出来形成氨基烷基衍生物。 衍生物也是从LSD核的哌啶氮中合成的。 然后可以在这些官能化位置进一步修饰所得到的半抗原，以连接到合适的抗原或标记基团，为LSD和非LSD具有优异的灵敏度和选择性的LSD免疫测定提供试剂。

    Propoxyphene derivatives for immunoassay reagents
    5.
    发明授权
    Propoxyphene derivatives for immunoassay reagents 失效
    丙氧芬衍生物用于免疫测定试剂

    公开(公告)号：US6004824A

    公开(公告)日：1999-12-21

    申请号：US886800

    申请日：1997-07-02

    申请人： Robert Sundoro Wu

    发明人： Robert Sundoro Wu

    IPC分类号： G01N33/53 ,  C07C229/14 ,  C07C229/38 ,  C07D493/10 ,  C07K14/76 ,  C07K16/44 ,  C09K11/06 ,  G01N33/94 ,  G01N33/533 ,  C07K17/08 ,  G01N33/534 ,  G01N33/535

    CPC分类号： C07D493/10 ,  C07C229/14 ,  C07C229/38 ,  C07K16/44 ,  G01N33/9486 ,  Y10S436/815 ,  Y10S530/807

    摘要： The present invention provides hapten derivatives that are useful for the preparation of antigenic, antibody and label reagents having superior performance characteristics for use in immunoassays for the detection of d-propoxyphene and d-nor-propoxyphene. In the present invention the propoxyphene nucleus is derivatized out of the nitrogen center to form an aminoalkyl -carboxyl, or -hydroxyl haptenic derivative. The resulting hapten can then be further modified at the now functionalized position off the nitrogen for linking to an appropriate antigenic or labeling group to provide reagents for propoxyphene immunoassays having excellent sensitivity and selectivity for both d-propoxyphene and d-nor-propoxyphene.

    摘要翻译： 本发明提供半抗原衍生物，其可用于制备具有优异的性能特征的抗原性，抗体和标记试剂，用于检测D-丙氧芬和D-去甲氧基苯酚的免疫测定。 在本发明中，丙氧芬核从氮中心衍生出氨基烷基 - 羧基或羟基半抗原衍生物。 然后，所得的半抗原可以在氮的现在官能化位置进一步修饰，以便连接到合适的抗原或标记基团，以提供对D-丙氧芬和D-异丙氧吩具有优异的灵敏度和选择性的丙氧芬免疫测定试剂。

    Methods of making propoxphene derivatives
    6.
    发明授权
    Methods of making propoxphene derivatives 失效
    制备丙炔衍生物的方法

    公开(公告)号：US5817529A

    公开(公告)日：1998-10-06

    申请号：US843136

    申请日：1997-04-28

    申请人： Robert Sundoro Wu

    发明人： Robert Sundoro Wu

    IPC分类号： G01N33/53 ,  C07C229/14 ,  C07C229/38 ,  C07D493/10 ,  C07K14/76 ,  C07K16/44 ,  C09K11/06 ,  G01N33/94 ,  G01N33/532 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535

    CPC分类号： C07D493/10 ,  C07C229/14 ,  C07C229/38 ,  C07K16/44 ,  G01N33/9486 ,  Y10S436/815 ,  Y10S530/807

    摘要： The present invention provides hapten derivatives that are useful for the preparation of antigenic, antibody and label reagents having superior performance characteristics for use in immunoassays for the detection of d-propoxyphene and d-nor-propoxyphene. In the present invention the propoxyphene nucleus is derivatized out of the nitrogen center to form an aminoalkyl -carboxyl, -amino, -thiol or -hydroxyl haptenic derivative. The resulting hapten can then be further modified at the now functionalized position off the nitrogen for linking to an appropriate antigenic or labelling group to provide reagents for propoxyphene immunoassays having excellent sensitivity and selectivity for both d-propoxyphene and d-nor-propoxyphene.

    摘要翻译： 本发明提供半抗原衍生物，其可用于制备具有优异的性能特征的抗原性，抗体和标记试剂，用于检测D-丙氧芬和D-去甲氧基苯酚的免疫测定。 在本发明中，丙氧芬核从氮中心衍生出氨基烷基 - 羧基 - 氨基， - 硫醇或 - 羟基半抗原衍生物。 然后，所得的半抗原可以在氮的现在官能化位置进一步修饰，以便连接到合适的抗原或标记基团，以提供对D-丙氧芬和D-异丙氧吩具有优异的灵敏度和选择性的丙氧芬免疫测定试剂。