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    MODIFIED RELEASE PHARMACEUTICAL COMPOSITION AND A PROCESS OF MAKING THE SAME
    1.
    发明申请
    MODIFIED RELEASE PHARMACEUTICAL COMPOSITION AND A PROCESS OF MAKING THE SAME 审中-公开
    改性释放药物组合物及其制备方法

    公开(公告)号：US20100056493A1

    公开(公告)日：2010-03-04

    申请号：US12522185

    申请日：2008-01-24

    申请人： Rajesh Jain ,  Kour Chand Jindal ,  Sanjay Boldhane

    发明人： Rajesh Jain ,  Kour Chand Jindal ,  Sanjay Boldhane

    IPC分类号： A61K31/554 ,  A61K31/5377

    CPC分类号： A61K9/2077

    摘要： The present invention refers to a modified release pharmaceutical composition comprising an in-situ gelling agent (=0.5 % w/w) and a gellation facilitating agent (e.g. calcium sulfate) in an amount of 2-17.5 % w/w. Additionally, the composition contains a release rate controlling polymer such as an acrylate and optionally a pH independent rate controlling polymer such as HPMC. A preferred active agent is mycophenolate mofetil. A process of making the above described composition is also disclosed.

    摘要翻译： 本发明涉及包含2-17.5％w / w的量的原位胶凝剂（= 0.5％w / w）和凝胶促进剂（例如硫酸钙）的改性释放药物组合物。 此外，组合物含有释放速率控制聚合物如丙烯酸酯和任选的pH独立的速率控制聚合物如HPMC。 优选的活性剂是霉酚酸酯。 还公开了制备上述组合物的方法。

    CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION
    2.
    发明申请
    CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION 审中-公开
    控制释放药物组合物

    公开(公告)号：US20130171199A1

    公开(公告)日：2013-07-04

    申请号：US13515482

    申请日：2010-12-20

    申请人： Sanjay Boldhane ,  Shripad Jathar ,  Maneesh Nerurkar

    发明人： Sanjay Boldhane ,  Shripad Jathar ,  Maneesh Nerurkar

    IPC分类号： A61K9/50

    CPC分类号： A61K9/50 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/1676 ,  A61K9/2081 ,  A61K9/5026 ,  A61K9/5078

    摘要： An oral controlled release pharmaceutical composition comprising a core and a polymer dispersion and its preparation method are disclosed. The core is selected from the group consisting of ‘the drug coated core’ and ‘the drug loaded core’. The drug coated core comprises an inert excipient based sphere and a coat of drug composition. The drug loaded core comprises at least a drug, a binder and at least one pharmaceutically acceptable excipient. The polymer dispersion used to coat the core comprises at least one controlled release polymer and at least one pharmaceutically acceptable excipient. The oral controlled release pharmaceutical composition further comprises an in-situ gelling system comprising at least one gelling polymer.

    摘要翻译： 公开了包含核心和聚合物分散体的口服控释药物组合物及其制备方法。 核心选自“药物包衣核心”和“载药核心”组。 药物包衣核心包含惰性赋形剂基球体和药物组合物涂层。 载药核心包含至少一种药物，粘合剂和至少一种药学上可接受的赋形剂。 用于包衣芯的聚合物分散体包含至少一种控释聚合物和至少一种药学上可接受的赋形剂。 口服释放药物组合物还包含包含至少一种胶凝聚合物的原位胶凝体系。