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公开(公告)号:US5298613A
公开(公告)日:1994-03-29
申请号:US879644
申请日:1992-05-12
申请人: Prasanta R. Chakraborty , Alex Elbrecht , Michael Dashkevicz , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
发明人: Prasanta R. Chakraborty , Alex Elbrecht , Michael Dashkevicz , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
CPC分类号: C12Q1/6893
摘要: Unique species-specific Eimeria acervulina DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria acervulina.
摘要翻译: 公开了包含发散DNA序列的独特物种特异性艾美球虫艾美球虫DNA探针。 探针与艾美球虫的小亚基核糖体RNA基因互补。
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公开(公告)号:US5359050A
公开(公告)日:1994-10-25
申请号:US879640
申请日:1992-05-12
申请人: Prasanta R. Chakraborty , Alex Elbrecht , Michael Dashkevicz , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
发明人: Prasanta R. Chakraborty , Alex Elbrecht , Michael Dashkevicz , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
CPC分类号: C12Q1/6893
摘要: Unique species-specific Eimeria mitis DNA probes comprising divergent DNA sequences are disclosed. The probes ere complementary to a small subunit ribosomal RNA gene of Eimeria mitis.
摘要翻译: 公开了包含发散DNA序列的独特种特异性艾美球虫DNA探针。 探针与艾美球虫的小亚基核糖体RNA基因互补。
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公开(公告)号:US06242199B1
公开(公告)日:2001-06-05
申请号:US09077675
申请日:1998-06-03
申请人: Lee-Yuh Pai , Scott D. Feighner , Andrew D. Howard , Sheng-Shung Pong , Leonardus H. T. Van Der Ploeg
发明人: Lee-Yuh Pai , Scott D. Feighner , Andrew D. Howard , Sheng-Shung Pong , Leonardus H. T. Van Der Ploeg
IPC分类号: G01N33566
CPC分类号: G01N33/74 , C07K14/723 , C12Q1/6897 , G01N2333/726 , G01N2500/10
摘要: An assay for the detection of growth hormone secretagogue receptors and growth hormone secretagogue related receptors is described. As these receptors are a member of the G protein coupled receptors, a subunit of the G protein must be present in order for expression to be detected. A similar assay is described where the presence of growth hormone secretagogues are detected.
摘要翻译: 描述了用于检测生长激素促分泌素受体和生长激素促分泌素相关受体的测定法。 由于这些受体是G蛋白偶联受体的成员,所以必须存在G蛋白的亚基以便表达被检测。 描述了检测到生长激素促分泌素的存在的类似的测定。
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公开(公告)号:US5449768A
公开(公告)日:1995-09-12
申请号:US879594
申请日:1992-05-12
申请人: Prasanta R. Chakraborty , Michael Dashkevicz , Alex Elbrecht , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
发明人: Prasanta R. Chakraborty , Michael Dashkevicz , Alex Elbrecht , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
CPC分类号: C12Q1/6893
摘要: Unique species-specific Eimeria praecox DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria praecox.
摘要翻译: 公开了包含发散DNA序列的独特物种特异性艾美球虫praecox DNA探针。 探针与艾美球虫的小亚基核糖体RNA基因互补。
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公开(公告)号:US5350763A
公开(公告)日:1994-09-27
申请号:US75253
申请日:1993-06-11
IPC分类号: A61K31/335 , A61K31/365 , C07D321/10
CPC分类号: A61K31/335 , A61K31/365 , C07D321/10
摘要: Unguinol is a well-known metabolite of the fungi Aspergillus unguis and Aspergillus nidulans. Unguinol has been found to be an active growth permittant and promotant in animals, in particular, monogastric animals such as chickens. In addition, the fermentation broth also produced the additional known unguinol derivatives of folipastatin and 2-chloro unguinol as well as the novel 4-methyl derivative. All of these compounds are active animal growth permittants. Compositions containing such unguinol derivatives for use as growth permittants and promotants are also disclosed.
摘要翻译: Unguinol是真菌Aspergillus unguis和构巢曲霉的着名代谢物。 已经发现乌尼诺醇是动物中的活性生长促进剂和促进剂,特别是单胃动物例如鸡。 此外,发酵液还产生了另外已知的叶酸酯和2-氯壬基酚的非诺醇衍生物以及新的4-甲基衍生物。 所有这些化合物都是活性动物生长容许剂。 还公开了含有用作生长剂和促进剂的非诺醇衍生物的组合物。
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公开(公告)号:US5278298A
公开(公告)日:1994-01-11
申请号:US879584
申请日:1992-05-12
申请人: Prasanta R. Chakraborty , Alex Elbrecht , Michael Dashkevicz , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
发明人: Prasanta R. Chakraborty , Alex Elbrecht , Michael Dashkevicz , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
CPC分类号: C12Q1/6893
摘要: Unique species-specific Eimeria brunetti DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria brunetti.
摘要翻译: 公开了包含发散DNA序列的独特物种特异性艾美球虫(Eimeria brunetti)DNA探针。 探针与艾美球虫的小亚基核糖体RNA基因互补。
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公开(公告)号:US07179886B1
公开(公告)日:2007-02-20
申请号:US09719485
申请日:1999-06-08
申请人: Scott D. Feighner , Arthur A. Patchett , Carina Tan , Karen Kulju McKee , Douglas MacNeil , Andrew D. Howard , Sheng-Shung Pong , Roy G. Smith
发明人: Scott D. Feighner , Arthur A. Patchett , Carina Tan , Karen Kulju McKee , Douglas MacNeil , Andrew D. Howard , Sheng-Shung Pong , Roy G. Smith
CPC分类号: C07K14/705 , G01N2500/10
摘要: The motilin receptor has been isolated and cloned, and nucleic acid sequences are given. Two spice variants have been identified. Also, assays for motilin receptor ligands are given. The identification of the cloned motilin receptor may be used to screen and identify compounds which bind to the receptor for use in a variety of gastric conditions, including gastric motility disorders.
摘要翻译: 已经分离并克隆了胃动素受体,并给出了核酸序列。 已经鉴定了两种香料变体。 此外,给出了胃动素受体配体的测定。 克隆的胃动素受体的鉴定可用于筛选和鉴定结合受体的化合物,以用于各种胃病症状,包括胃动力障碍。
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公开(公告)号:US06531314B1
公开(公告)日:2003-03-11
申请号:US09077674
申请日:1998-06-03
申请人: Joseph P. Arena , Doris F. Cully , Scott D. Feighner , Andrew D. Howard , Paul A. Liberator , James M. Schaeffer , Leonardus H. T. Van Der Ploeg
发明人: Joseph P. Arena , Doris F. Cully , Scott D. Feighner , Andrew D. Howard , Paul A. Liberator , James M. Schaeffer , Leonardus H. T. Van Der Ploeg
IPC分类号: C12N1500
CPC分类号: C07B59/002 , A61K38/00 , C07K14/723
摘要: Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.
摘要翻译: 人,猪和大鼠生长激素促分泌素受体已被分离,克隆和测序。 生长激素促分泌受体是G-蛋白家族受体的新成员。 生长激素促分泌素受体可用于筛选和鉴定结合生长激素促分泌素受体的化合物。 这些化合物可用于治疗当生长激素短缺时发生的病症,例如在生长激素缺乏的儿童,老年骨骼肌损伤患者和从髋部骨折和骨质疏松症中恢复的情况。
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公开(公告)号:US5563256A
公开(公告)日:1996-10-08
申请号:US879469
申请日:1992-05-12
申请人: Prasanta R. Chakraborty , Michael Dashkevicz , Alex Elbrecht , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
发明人: Prasanta R. Chakraborty , Michael Dashkevicz , Alex Elbrecht , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
CPC分类号: C12Q1/6893
摘要: Unique species-specific Eimeria tenella DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria tenella.
摘要翻译: 公开了包含发散DNA序列的独特物种特异性艾美球虫艾氏杆菌DNA探针。 探针与艾美球虫的小亚基核糖体RNA基因互补。
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公开(公告)号:US5288845A
公开(公告)日:1994-02-22
申请号:US879470
申请日:1992-05-12
申请人: Prasanta R. Chakraborty , Michael Dashkevicz , Alex Elbrecht , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
发明人: Prasanta R. Chakraborty , Michael Dashkevicz , Alex Elbrecht , Scott D. Feighner , Paul A. Liberator , Helen Profous-Juchelka
CPC分类号: C12Q1/6893
摘要: Unique species-specific Eimeria necatrix DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria necatrix.
摘要翻译: 公开了包含发散DNA序列的独特物种特异性艾美虫亚种DNA探针。 探针与艾美球虫的小亚基核糖体RNA基因互补。
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