Treatment of prostate disease with a nonsteroidal anti-androgenic
compound
    8.
    发明授权
    Treatment of prostate disease with a nonsteroidal anti-androgenic compound 失效
    用非甾体抗雄激素化合物治疗前列腺疾病

    公开(公告)号:US5872150A

    公开(公告)日:1999-02-16

    申请号:US806944

    申请日:1997-02-26

    CPC分类号: A61K31/165

    摘要: An assay for identifying compounds with antiandrogenic activity employing a hamster ductus deferens cell line (DDT1) ATCC CRL-1701 and ATCC CRL-12051 is disclosed, as well as antiandrogenic compounds identified from this assay, particularly the nonsteroidal compound N-(4-chlorophenyl)-(Z,Z)-2,3-bis(cyclopropylmethylene)cyclopentane carboxamide of structural formula (I): ##STR1## This compound is an antiandrogen useful in the treatment and prevention of diseases of the prostate including prostatitis, benign prostatic hyperplasia (BPH) and prostatic carcinoma.

    摘要翻译: 公开了使用仓鼠导管输精管细胞系(DDT1)ATCC CRL-1701和ATCC CRL-12051鉴定具有抗雄激素活性的化合物的测定法,以及从该测定鉴定的抗雄激素化合物,特别是非甾体化合物N-(4-氯苯基 ) - (Z,Z)-2,3-双(环丙基亚甲基)环戊烷甲酰胺:该化合物是可用于治疗和预防前列腺疾病的抗雄激素,包括前列腺炎, 良性前列腺增生(BPH)和前列腺癌。