公开(公告)号：US09868937B2

公开(公告)日：2018-01-16

申请号：US14122226

申请日：2012-05-29

申请人： Michael Regnier ,  Michael Laflamme ,  Charles Murry ,  F. Steven Korte ,  Scott Lundy ,  Stephen Denison Hauschka ,  Jeffrey S. Chamberlain ,  Guy Odom

发明人： Michael Regnier ,  Michael Laflamme ,  Charles Murry ,  F. Steven Korte ,  Scott Lundy ,  Stephen Denison Hauschka ,  Jeffrey S. Chamberlain ,  Guy Odom

IPC分类号： C12N5/077 ,  C12N9/02 ,  A01K67/027 ,  A61K48/00 ,  C07K14/47 ,  C12N15/85 ,  A61K9/00 ,  A61K35/34 ,  C12N7/00 ,  C12N15/86

CPC分类号： C12N5/0657 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K9/0019 ,  A61K35/34 ,  A61K48/005 ,  C07K14/4716 ,  C12N7/00 ,  C12N9/0093 ,  C12N15/8509 ,  C12N15/86 ,  C12N2750/14132 ,  C12N2750/14143 ,  C12N2799/022 ,  C12N2799/025 ,  C12Y117/04001 ,  C12Y117/04002

摘要： Compositions and methods for improving cardiac function, myocardial contractility and relaxation in a mammal are provided. Cardiomyocytes transfected with one or more expression vectors comprising a ribonucleotide reductase subunit R1-encoding nucleic acid sequence and a ribonucleotide reductase subunit R2-encoding nucleic acid sequence operably linked to a promoter are grafted to a mammalian myocardium. Also provided are compositions and methods for delivering dATP to a myocardium through grafting of donor cells overexpressing R1 and R2. dATP is thereby produced in situ and delivered through gap junctions established between donor cells and host cardiomyocytes. Alternatively, viral vector(s) having the R1 and R2-encoding construct(s) are administered to the mammal directly. Improvement of cardiac function can also be effected by administration of vectors comprising a nucleic acid sequence encoding a L48Q, 61 Q, or L57Q cTnC variant.

公开(公告)号：US5954909A

公开(公告)日：1999-09-21

申请号：US808388

申请日：1997-02-28

申请人： Daniel Davidsohn ,  Scott Lundy ,  Rainer Meinke ,  Gerald Stelzer ,  Mark W. Senti

发明人： Daniel Davidsohn ,  Scott Lundy ,  Rainer Meinke ,  Gerald Stelzer ,  Mark W. Senti

IPC分类号： H01F41/12 ,  B32B31/00

CPC分类号： H01F41/12

摘要： Process of adhering conductors such as bare copper wire, copper wire with polymide insulation, and multistrand Kapton wrapped superconductors to mount structures such as a cylinder of arbitrary cross sections, a saddle support, or steel tubes using adhesive layers of material such as BONDALL 16-H, 3M-2090 and T-164. The adhesive layers are subject to b-staging before being used, where it is heated to a temperature of approximately 60-100.degree. C. for approximately 1/2 hour to approximately one hour. The support surface can optionally be grooved to allow for better wire placement and no wire slippage.

摘要翻译： 粘接诸如裸铜线，具有聚酰亚胺绝缘体的铜线和多股卡普顿包覆超导体等导体的工艺可以安装任意横截面的圆柱体，鞍形支架或使用诸如BONDALL 16- H，3M-2090和T-164。 粘合剂层在使用之前经历b阶段，其中将其加热至约60-100℃的温度约+ E，从1/2 + EE小时至约1小时。 支撑表面可以可选地被开槽，以允许更好的导线放置和没有线滑动。