公开(公告)号：US20230322925A1

公开(公告)日：2023-10-12

申请号：US18189433

申请日：2023-03-24

申请人： Seattle Children’s Hospital (dba Seattle Children’s Research Institute)

发明人： Michael C. Jensen ,  James Matthaei

IPC分类号： C07K16/32 ,  A61P35/00 ,  C07K16/08 ,  C07K16/12 ,  C07K16/28 ,  A61K47/54 ,  C07K16/30

CPC分类号： C07K16/2809 ,  A61K47/544 ,  A61P35/00 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  C07K16/32 ,  A61K2039/5158 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/33

摘要： Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.

公开(公告)号：US20240293463A1

公开(公告)日：2024-09-05

申请号：US18643312

申请日：2024-04-23

申请人： The Regents of the University of California ,  Seattle Children’s Hospital DBA Seattle Children’s Research Institute

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/46 ,  C12N5/0783

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/46 ,  C12N5/0636 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/40 ,  C12N2510/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.