公开(公告)号：US20240293463A1

公开(公告)日：2024-09-05

申请号：US18643312

申请日：2024-04-23

申请人： The Regents of the University of California ,  Seattle Children’s Hospital DBA Seattle Children’s Research Institute

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/46 ,  C12N5/0783

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/46 ,  C12N5/0636 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/40 ,  C12N2510/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US11160833B2

公开(公告)日：2021-11-02

申请号：US17028701

申请日：2020-09-22

申请人： The Regents of the University of California ,  Seattle Children's Hospital

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： C07K16/00 ,  C12P21/08 ,  G01N33/53 ,  G01N33/567 ,  C12N5/00 ,  C12N5/16 ,  A61K35/17 ,  C07K16/46 ,  C12N5/0783 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  C07K1/00 ,  A61K38/00 ,  A61K39/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US11253546B2

公开(公告)日：2022-02-22

申请号：US15535972

申请日：2015-12-14

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SEATTLE CHILDREN'S HOSPITAL

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： A61K39/395 ,  A61K39/40 ,  A61K35/17 ,  C07K16/46 ,  C12N5/0783 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  C07K16/00 ,  A61K38/00 ,  A61K39/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US20240261334A1

公开(公告)日：2024-08-08

申请号：US18623246

申请日：2024-04-01

申请人： The Regents of the University of California ,  Seattle Children's Hospital DBA Seattle Children's Research Institute

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/46 ,  C12N5/0783

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/46 ,  C12N5/0636 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/40 ,  C12N2510/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US12053491B2

公开(公告)日：2024-08-06

申请号：US18238210

申请日：2023-08-25

申请人： The Regents of the University of California ,  Seattle Children's Hospital

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/46 ,  C12N5/0783 ,  A61K38/00 ,  A61K39/00

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/46 ,  C12N5/0636 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/40 ,  C12N2510/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US11944648B2

公开(公告)日：2024-04-02

申请号：US18238210

申请日：2023-08-25

申请人： The Regents of the University of California ,  Seattle Children's Hospital

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/46 ,  C12N5/0783 ,  A61K38/00 ,  A61K39/00

CPC分类号： A61K35/17 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/46 ,  C12N5/0636 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/40 ,  C12N2510/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US20240024359A1

公开(公告)日：2024-01-25

申请号：US18238210

申请日：2023-08-25

申请人： The Regents of the University of California ,  Seattle Children's Hospital DBA Seattle Children's Research Institute

发明人： Yvonne Y. Chen ,  Eugenia Zah ,  Michael C. Jensen

IPC分类号： A61K35/17 ,  C07K16/46 ,  C12N5/0783 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705

CPC分类号： A61K35/17 ,  C07K16/46 ,  C12N5/0636 ,  C07K16/2803 ,  C07K16/2887 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  A61K38/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.