公开(公告)号：US20120107900A1

公开(公告)日：2012-05-03

申请号：US13139990

申请日：2009-12-18

申请人： Andreas Greiner ,  Seema Agarwal ,  Marco Gensheimer

发明人： Andreas Greiner ,  Seema Agarwal ,  Marco Gensheimer

IPC分类号： C12N11/12 ,  B29C47/00 ,  C12N11/08

CPC分类号： C12N1/04 ,  C12N11/04 ,  D01D5/0007 ,  D01F1/10

摘要： The present invention provides electrospun polymer fibers comprising bacteria-containing hydrogel particles. Bacteria-containing hydrogel particles are produced by crosslinking water-soluble polymers to form hydrogels and mixing them with a bacteria suspension. The crosslinking is suitable to be carried out either chemically before the addition of the bacteria suspension or physically before or after this addition. Subsequently, these hydrogel particles are electrospun together with an electrospinnable polymer solution to form fibers or fibre non-wovens.The bacteria which are located in these hydrogel particles or in the electrospun polymer fibers comprising these particles, respectively, are capable of surviving for a long period (several months) without the supply of water or cell-culture media and are simultaneously protected against the effect of solvents, for example alcohols, acetone, chlorinated hydrocarbons, ethers and toluene, which would otherwise kill said bacteria. The bacteria are suitable to be released again at any time through contact with water and to be replicated under normal culture conditions.The electrospun polymer fibers according to the present invention comprising bacteria-containing hydrogels are suitable for use in the dry storage of useful bacteria or for killing harmful bacteria. Textiles and membranes, for example, are suitable to be equipped with it. However, they are also suitable for applications in wastewater treatment, environmental protection (water pollution control), the agricultural and food sector, pharmacy, fermentation, and the building industry.

摘要翻译： 本发明提供了包含含细菌的水凝胶颗粒的电纺聚合物纤维。 通过交联水溶性聚合物以形成水凝胶并将其与细菌悬浮液混合来制备含细菌的水凝胶颗粒。 交联适用于在添加细菌悬浮液之前进行化学反应，或在物理加入之前或之后进行。 随后，将这些水凝胶颗粒与电纺丝聚合物溶液一起电纺丝以形成纤维或纤维无纺布。 分别位于这些水凝胶颗粒或包含这些颗粒的电纺聚合物纤维中的细菌能够长时间（几个月）存活，而不需要供应水或细胞培养基，并同时被保护免受影响 的溶剂，例如醇，丙酮，氯代烃，醚和甲苯，否则会杀死所述细菌。 细菌可以随时通过与水接触再次释放并在正常培养条件下复制。 包含含细菌水凝胶的本发明的电纺聚合物纤维适用于干燥储存有用细菌或杀死有害细菌。 纺织品和膜例如适合配备它。 但也适用于污水处理，环境保护（水污染防治），农副食品，制药，发酵，建筑等行业。

公开(公告)号：US20110160426A1

公开(公告)日：2011-06-30

申请号：US12937631

申请日：2009-04-09

申请人： Andreas Greiner ,  Seema Agarwal ,  Thomas Kissel ,  Liqun Ren

发明人： Andreas Greiner ,  Seema Agarwal ,  Thomas Kissel ,  Liqun Ren

IPC分类号： C08G63/685 ,  C08G63/68 ,  C08G75/24 ,  C08G63/692 ,  C09J167/00 ,  B82Y40/00

CPC分类号： C08L101/16 ,  C08F8/44 ,  C08F216/38 ,  C08F220/14 ,  C08F220/34 ,  C08F2800/10 ,  C08F120/34

摘要： The invention at hand provides hydrolytically degradable ionic copolymers. These ionic copolymerizates are composed of one cyclic ketene acetal A, one anionic or cationic methacrylic acid derivative B, selected from 2-methyl-methacrylate, [2-(2-methyl-1-methylene-allyloxy)]ethanesulfonate, [2-(2-methyl-1-methylene-allyloxy)ethyl]phosphonate or a quaternary amine of the N,N-dimethylaminoethylmethacrylic acid (DMAEMA) and, optionally, a neutral methacrylic acid derivative C.The hydrolytically degradable anionic copolymers according to the present invention are produced by polymerizing the components A, B and C in the presence of a radical initiator under inert gas atmosphere and subsequent purification.All copolymers according to the present invention are hydrolytically degradable. Copolymers comprising a maximum of 40 mol-% of ester groups in the backbone are additionally biodegradable, wherein in the case of cationic copolymers a maximum of 20 mol-% of quaternized DMAEMA is allowed to be available.Cationic copolymers comprising at least 50 mol-% of the component B are antimicrobial.Both anionic as well as cationic copolymers are suitable for producing nanoparticles. Cationic copolymers are suitable for being used as superhydrophobic materials as well as adhesives. Anionic copolymers are suitable for biodegradable thermoplastic elastomers and for biodegradable ionomers.

摘要翻译： 本发明提供了可水解降解的离子共聚物。 这些离子共聚物由选自2-甲基 - 甲基丙烯酸酯，[2-（2-甲基-1-亚甲基 - 烯丙氧基）]乙磺酸酯，[2-（2-甲基-1-亚甲基 - 烯丙氧基）]乙磺酸的一种环状烯酮缩醛A，一种阴离子或阳离子甲基丙烯酸衍生物B组成， 2-甲基-1-亚甲基 - 烯丙氧基）乙基]膦酸酯或N，N-二甲基氨基乙基甲基丙烯酸（DMAEMA）和任选的中性甲基丙烯酸衍生物C的季胺。根据本发明的可水解降解的阴离子共聚物是 通过在惰性气体气氛下在自由基引发剂的存在下将组分A，B和C聚合并随后纯化而制备。 根据本发明的所有共聚物都是可水解降解的。 在主链中包含最多40mol％的酯基的共聚物另外是可生物降解的，其中在阳离子共聚物的情况下，允许最多20mol％的季铵化DMAEMA可用。 包含至少50mol％的组分B的阳离子共聚物是抗微生物剂。 阴离子和阳离子共聚物都适用于生产纳米颗粒。 阳离子共聚物适合用作超疏水材料以及粘合剂。 阴离子共聚物适用于可生物降解的热塑性弹性体和可生物降解的离聚物。

公开(公告)号：US08871881B2

公开(公告)日：2014-10-28

申请号：US11884884

申请日：2006-02-23

申请人： Andreas Greiner ,  Seema Agarwal ,  Michael Bognitzki ,  Sven Horst

发明人： Andreas Greiner ,  Seema Agarwal ,  Michael Bognitzki ,  Sven Horst

IPC分类号： C08F214/18

CPC分类号： C09D5/1662 ,  C08F12/20 ,  C08G61/025 ,  C08G2261/11 ,  C08G2261/146 ,  C08G2261/15 ,  C08G2261/3424 ,  C08G2261/42 ,  D01D5/0038 ,  D01F6/42 ,  D06M15/233

摘要： The invention at hand concerns hydrophobic polymer surfaces, in particular superhydrophobic polymer surfaces, comprising at least one homo- or copolymer, which comprises at least one side chain with at least one fluoro-substituted aryl group. Furthermore, the invention at hand concerns a method for the production of polymer surfaces of this type, their use and polymers of the general formula I: wherein n is an integer between 10 and 4,500, preferably between 20 and 2,200 and particularly preferably between 100 and 670.

摘要翻译： 本发明涉及包含至少一种均聚物或共聚物的疏水聚合物表面，特别是超疏水聚合物表面，其包含至少一个具有至少一个氟取代的芳基的侧链。 此外，本发明涉及一种生产这种聚合物表面的方法，它们的用途和通式I的聚合物：其中n是10至4,500，优选20-2200之间的整数，特别优选在100和 670。

公开(公告)号：US20120259064A1

公开(公告)日：2012-10-11

申请号：US13509185

申请日：2010-11-12

申请人： Andreas Greiner ,  Seema Agarwal ,  Claudia Mattheis

发明人： Andreas Greiner ,  Seema Agarwal ,  Claudia Mattheis

IPC分类号： C08G73/02 ,  C08L75/04 ,  C08G18/08 ,  C08F8/32 ,  C08G73/06

CPC分类号： C08G73/0616 ,  A61K31/785 ,  C08G73/0206 ,  C08G73/0213 ,  C08G73/0273 ,  C08L79/02

摘要： The invention provides new polymeric or oligomeric active agents with a biocidal effect. Such particularly advantageous polymeric or oligomeric active agents with a biocidal effect are obtainable via polycondensation of a guanidine acid addition salt with an amine mixture comprising at least one diamine and/or one triamine, wherein at least one amine is selected from the group comprising i) diamine, comprising at least one cycloaliphatic residue, and ii) dialkylenetriamine. At least one amine is hereby preferably selected from 4,4′-methylenebis(cyclohexylamine) and diethylenetriamine. Furthermore, it is favorable if the guanidine acid addition salt is guanidinehydrochloride.

摘要翻译： 本发明提供具有杀生物作用的新型聚合物或低聚物活性剂。 具有杀生物作用的这种特别有利的聚合物或低聚物活性剂可以通过胍酸加成盐与包含至少一种二胺和/或一种三胺的胺混合物的缩聚获得，其中至少一种胺选自i） 二胺，包含至少一个脂环族残基，和ii）二亚烷基三胺。 因此，优选至少一种胺选自4,4'-亚甲基双（环己胺）和二亚乙基三胺。 此外，如果胍酸加成盐是盐酸胍，则是有利的。

公开(公告)号：US09068065B2

公开(公告)日：2015-06-30

申请号：US12937631

申请日：2009-04-09

申请人： Andreas Greiner ,  Seema Agarwal ,  Thomas Kissel ,  Liqun Ren

发明人： Andreas Greiner ,  Seema Agarwal ,  Thomas Kissel ,  Liqun Ren

IPC分类号： C08F20/06 ,  C08L101/16 ,  C08F8/44 ,  C08F220/34 ,  C08F216/38 ,  C08F220/14

CPC分类号： C08L101/16 ,  C08F8/44 ,  C08F216/38 ,  C08F220/14 ,  C08F220/34 ,  C08F2800/10 ,  C08F120/34

摘要： The invention at hand provides hydrolytically degradable ionic copolymers. These ionic copolymerizates are composed of one cyclic ketene acetal A, one anionic or cationic methacrylic acid derivative B, selected from 2-methyl-methacrylate, [2-(2-methyl-1-methylene-allyloxy)]ethanesulfonate, [2-(2-methyl-1-methylene-allyloxy)ethyl]phosphonate or a quaternary amine of the N,N-dimethylaminoethylmethacrylic acid (DMAEMA) and, optionally, a neutral methacrylic acid derivative C.The hydrolytically degradable anionic copolymers according to the present invention are produced by polymerizing the components A, B and C in the presence of a radical initiator under inert gas atmosphere and subsequent purification.All copolymers according to the present invention are hydrolytically degradable. Copolymers comprising a maximum of 40 mol-% of ester groups in the backbone are additionally biodegradable, wherein in the case of cationic copolymers a maximum of 20 mol-% of quaternized DMAEMA is allowed to be available.Cationic copolymers comprising at least 50 mol-% of the component B are antimicrobial.Both anionic as well as cationic copolymers are suitable for producing nanoparticles. Cationic copolymers are suitable for being used as superhydrophobic materials as well as adhesives. Anionic copolymers are suitable for biodegradable thermoplastic elastomers and for biodegradable ionomers.

摘要翻译： 本发明提供了可水解降解的离子共聚物。 这些离子共聚物由选自2-甲基 - 甲基丙烯酸酯，[2-（2-甲基-1-亚甲基 - 烯丙氧基）]乙磺酸酯，[2-（2-甲基-1-亚甲基 - 烯丙氧基）]乙磺酸的一种环状烯酮缩醛A，一种阴离子或阳离子甲基丙烯酸衍生物B组成， 2-甲基-1-亚甲基 - 烯丙氧基）乙基]膦酸酯或N，N-二甲基氨基乙基甲基丙烯酸（DMAEMA）和任选的中性甲基丙烯酸衍生物C的季胺。根据本发明的可水解降解的阴离子共聚物是 通过在惰性气体气氛下在自由基引发剂的存在下将组分A，B和C聚合并随后纯化而制备。 根据本发明的所有共聚物都是可水解降解的。 在主链中包含最多40mol％的酯基的共聚物另外是可生物降解的，其中在阳离子共聚物的情况下，允许最多20mol％的季铵化DMAEMA可用。 包含至少50mol％的组分B的阳离子共聚物是抗微生物剂。 阴离子和阳离子共聚物都适用于生产纳米颗粒。 阳离子共聚物适合用作超疏水材料以及粘合剂。 阴离子共聚物适用于可生物降解的热塑性弹性体和可生物降解的离聚物。

公开(公告)号：US20120302703A1

公开(公告)日：2012-11-29

申请号：US13147146

申请日：2010-02-01

申请人： Andreas Greiner ,  Seema Agarwal ,  Julia Schmidt ,  Stefan Bokern

发明人： Andreas Greiner ,  Seema Agarwal ,  Julia Schmidt ,  Stefan Bokern

IPC分类号： C08F8/42 ,  C08F20/14 ,  C08F12/08 ,  B82Y99/00

CPC分类号： C08F6/12 ,  A01N55/00 ,  B01J13/02 ,  B82Y30/00 ,  C08K3/08 ,  C08K9/08 ,  C08K9/10 ,  C09D5/14 ,  C09D5/24 ,  C09D7/62 ,  A01N25/26 ,  A01N25/34 ,  A01N2300/00

摘要： The present invention provides a method to produce metal-containing nanoparticles enveloped with polymers, as well as particles obtainable therefrom.In the method according to the present invention, at least one anionic polymerizable monomer is polymerized in the presence of an anionic macroinitiator at room temperature. Subsequently, an aliphatic or aromatic sulfide is firstly added, followed by a solution of at least one organosoluble metal salt in an aprotic organic solvent and finally a homogeneous reducing agent. The metal cation is hereby reduced to the metal. Metal-containing nanoparticles are formed which are covalently bonded to the growing anionic polymerizates.The metal salts are preferably salts of silver, copper, gold, tin, lead, chrome or zinc, or mixtures thereof. Anionic polymerizable monomers comprise, by way of example, styrene (St), butadiene, isoprene, ethylene oxide, propylene oxide, caprolactone, lactide, glycolide, acrylates, methacrylates, bisacrylates, cyanoacrylates, amides, siloxanes, vinylpyridines or acrylonitrile.The particles according to the present invention are suitable to be used for the antibacterial finishing of polymers in textiles and materials. Furthermore, they are suitable for the production of inks. If the underlying metals are those metals that show plasmon resonance, the particles are suitable to also be applied in sensors which use the plasmon resonance effect.The metal-containing nanoparticles enveloped with polymers which are accessible using the method according to the present invention do not aggregate or agglomerate, and their physical and chemical properties remain unchanged over a long period of time.

摘要翻译： 本发明提供一种制备包封有聚合物的含金属纳米颗粒的方法，以及由其获得的颗粒。 在根据本发明的方法中，至少一种阴离子可聚合单体在阴离子大分子引发剂的存在下在室温下聚合。 随后，首先加入脂族或芳族硫化物，然后加入至少一种有机溶剂金属盐在非质子有机溶剂中的溶液，最后加入均匀的还原剂。 因此金属阳离子被还原成金属。 形成含金属的纳米颗粒，其与生长的阴离子聚合物共价键合。 金属盐优选为银，铜，金，锡，铅，铬或锌的盐，或其混合物。 阴离子可聚合单体包括例如苯乙烯（St），丁二烯，异戊二烯，环氧乙烷，环氧丙烷，己内酯，丙交酯，乙交酯，丙烯酸酯，甲基丙烯酸酯，双丙烯酸酯，氰基丙烯酸酯，酰胺，硅氧烷，乙烯基吡啶或丙烯腈。 根据本发明的颗粒适合用于织物和材料中聚合物的抗菌整理。 此外，它们适用于油墨的生产。 如果下面的金属是显示等离子体共振的那些金属，则该颗粒也适用于也使用等离子体共振效应的传感器。 用聚合物包裹的含金属纳米颗粒可以使用根据本发明的方法进行接触，不会聚集或附聚，并且其物理和化学性质在长时间内保持不变。

公开(公告)号：US20130214441A1

公开(公告)日：2013-08-22

申请号：US13816701

申请日：2011-08-12

申请人： Andreas Greiner ,  Seema Agarwal ,  Kathrin Bubel

发明人： Andreas Greiner ,  Seema Agarwal ,  Kathrin Bubel

IPC分类号： C08L67/02

CPC分类号： C08L67/02 ,  C08G63/672 ,  C08L67/025 ,  D01D1/02 ,  D01D5/0038 ,  D01F6/62 ,  D01F6/92

摘要： The present invention provides aqueous stable suspensions of biodegradable diblock copolyesters and a method for their production. The diblock copolyesters comprise one block of an aliphatic polyester and one block of a polyethylene oxide.Suspensions according to the present invention are suitable to be used as biodegradable viscosity modifiers, compatibilizers in blends, as glues, varnishes, paper additives, flame retardants, impact modifiers and hazers of transparent plastics, and for the production of biodegradable sheets, films, fibers, plates, vessels, tubes and capillaries for transport or packaging purposes. Furthermore, the suspensions according to the present invention are suitable to be used for the production of nano- and microfibers and nano- and microfiber nonwovens with non-oriented or oriented fibers by means of electrospinning.

摘要翻译： 本发明提供可生物降解的二嵌段共聚酯的水性稳定悬浮液及其生产方法。 二嵌段共聚酯包含一个脂族聚酯块和一个聚环氧乙烷嵌段。 根据本发明的悬浮液适合用作可生物降解的粘度调节剂，共混物中的增容剂，如胶水，清漆，纸添加剂，阻燃剂，抗冲改性剂和透明塑料的混浊剂，以及用于生产可生物降解的片材，薄膜，纤维 ，板，容器，管和毛细管用于运输或包装目的。 此外，根据本发明的悬浮液适合用于通过静电纺丝生产具有非取向或定向纤维的纳米和微纤维以及纳米和微纤维非织造布。

公开(公告)号：US20090010870A1

公开(公告)日：2009-01-08

申请号：US11884884

申请日：2006-02-23

申请人： Andreas Greiner ,  Seema Agarwal ,  Michael Bognitzki ,  Sven Horst

发明人： Andreas Greiner ,  Seema Agarwal ,  Michael Bognitzki ,  Sven Horst

IPC分类号： A61K31/74 ,  C08F214/18

CPC分类号： C09D5/1662 ,  C08F12/20 ,  C08G61/025 ,  C08G2261/11 ,  C08G2261/146 ,  C08G2261/15 ,  C08G2261/3424 ,  C08G2261/42 ,  D01D5/0038 ,  D01F6/42 ,  D06M15/233

摘要： The invention at hand concerns hydrophobic polymer surfaces, in particular superhydrophobic polymer surfaces, comprising at least one homo- or copolymer, which comprises at least one side chain with at least one fluoro-substituted aryl group. Furthermore, the invention at hand concerns a method for the production of polymer surfaces of this type, their use and polymers of the general formula I: wherein n is an integer between 10 and 4,500, preferably between 20 and 2,200 and particularly preferably between 100 and 670.

摘要翻译： 本发明涉及包含至少一种均聚物或共聚物的疏水聚合物表面，特别是超疏水聚合物表面，其包含至少一个具有至少一个氟取代的芳基的侧链。 此外，本发明涉及一种生产这种聚合物表面的方法，它们的用途和通式I的聚合物：其中n是10至4,500，优选20-2200，特别优选在100和100之间的整数。 670。