公开(公告)号：US07919632B2

公开(公告)日：2011-04-05

申请号：US11917835

申请日：2006-06-07

申请人： Arnd Neeff ,  Sergiy Pazenok

发明人： Arnd Neeff ,  Sergiy Pazenok

IPC分类号： C07D231/16

CPC分类号： C07D231/16

摘要： The present invention relates to a novel process for preparing known fungicidally active 1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamides from the corresponding acid fluoride and aniline derivatives in the absence of an acid acceptor.

摘要翻译： 本发明涉及在不存在酸受体的情况下，由相应的酰氟和苯胺衍生物制备已知的杀真菌活性1,3-二甲基-5-氟-1H-吡唑-4-甲酰胺的新方法。

公开(公告)号：US07608736B2

公开(公告)日：2009-10-27

申请号：US10874966

申请日：2004-06-23

申请人： Sergiy Pazenok ,  Mark James Ford ,  Günter Schlegel

发明人： Sergiy Pazenok ,  Mark James Ford ,  Günter Schlegel

IPC分类号： C07C303/04 ,  C07C311/04

CPC分类号： C07C303/40 ,  C07C311/51

摘要： The invention relates to a process for the preparation of a compound of formula (I): Which comprises reaction of a compound of formula (II) with a compound of the formula (III) in the presence of a chlorinating agent, followed by reaction of the resultant compound of the formula (IV) with a compound of formula (V) in the presence of a base: wherein the various symbols are as defined in claim 1.

摘要翻译： 本发明涉及一种制备式（I）化合物的方法：其包括式（II）化合物与式（III）化合物在氯化剂存在下反应，随后将 所得式（Ⅳ）化合物与式（Ⅴ）化合物在碱存在下反应：其中各种符号如权利要求1所定义。

公开(公告)号：US06541640B2

公开(公告)日：2003-04-01

申请号：US10013470

申请日：2001-12-13

申请人： Sergiy Pazenok ,  Henricus Maria Martinus Bastiaans

发明人： Sergiy Pazenok ,  Henricus Maria Martinus Bastiaans

IPC分类号： C07D21312

CPC分类号： C07C255/24 ,  C07C255/27 ,  C07C255/30 ,  C07D211/78 ,  C07D211/90 ,  C07D213/85

摘要： 4-Haloalkylnicotinonitriles having the formula (I) which are suitable as intermediates in the preparation of pesticides, are obtained by: (a) reacting a 3-amino-1-haloalkyl-2-propen-1-one RF—C(O)—CH═CH—NH2  (II)  in a condensation reaction with a compound of the formula (III) to (VII), (R1Z)CH═CH—CN  (III) (R1Z)2CH—CH2—CN  (IV) Hal-CH═CH—CN  (V) Hal2CH—CH2CN  (VI) HC≡C—CN  (VII),  to give a compound of the formula (VIII), (IX) and/or (X), RF—C(O)—CH═CH—NH—CH═CH—CN  (VIII) RF—C(O)—CH═CH—NH—CH(ZR1)—CH2—CN  (IX) RF—C(O)—CH═CH—NH—CH(Hal)—CH2—CN  (X)  wherein RF is (C1-C4)-haloalkyl, R1 is alkyl, Hal is Cl or Br and each Z, independently, is O, S, NR or OCO; and (b) subjecting the reaction product to a ring closure reaction.

摘要翻译： 通过以下方法获得具有式（I）的适合作为制备农药中间体的式（I）的4-卤代烷基硝基腈：（a）使缩合反应中的3-氨基-1-卤代烷基-2-丙烯-1-酮与 得到式（VIII），（IX）和/或（X）的化合物，其中RF是（C 1 -C 4） - 卤代烷基，R 1是烷基，Hal是 Cl或Br，每个Z独立地是O，S，NR或OCO; 和（b）使反应产物进行闭环反应。

公开(公告)号：US08236986B2

公开(公告)日：2012-08-07

申请号：US12557727

申请日：2009-09-11

申请人： Sergiy Pazenok ,  Mark James Ford ,  Guenter Schlegel

发明人： Sergiy Pazenok ,  Mark James Ford ,  Guenter Schlegel

IPC分类号： C07C303/04 ,  C07C307/02

CPC分类号： C07C303/40 ,  C07C311/51

摘要： The invention relates to a process for the preparation of a compound of formula (I): Which comprises reaction of a compound of formula (II) with a compound of the formula (III) in the presence of a chlorinating agent, followed by reaction of the resultant compound of the formula (IV) with a compound of formula (V) in the presence of a base: wherein the various symbols are as defined in claim 1.

摘要翻译： 本发明涉及一种制备式（I）化合物的方法：其包括式（II）化合物与式（III）化合物在氯化剂存在下反应，随后将 所得式（Ⅳ）化合物与式（Ⅴ）化合物在碱存在下反应：其中各种符号如权利要求1所定义。

公开(公告)号：US20100094052A1

公开(公告)日：2010-04-15

申请号：US12557727

申请日：2009-09-11

申请人： Sergiy PAZENOK ,  Mark James FORD ,  Günter SCHLEGEL

发明人： Sergiy PAZENOK ,  Mark James FORD ,  Günter SCHLEGEL

IPC分类号： C07C307/02

CPC分类号： C07C303/40 ,  C07C311/51

摘要： The invention relates to a process for the preparation of a compound of formula (I): Which comprises reaction of a compound of formula (II) with a compound of the formula (III) in the presence of a chlorinating agent, followed by reaction of the resultant compound of the formula (IV) with a compound of formula (V) in the presence of a base: wherein the various symbols are as defined in claim 1.

摘要翻译： 本发明涉及一种制备式（I）化合物的方法：其包括式（II）化合物与式（III）化合物在氯化剂存在下反应，随后将 所得式（Ⅳ）化合物与式（Ⅴ）化合物在碱存在下反应：其中各种符号如权利要求1所定义。

公开(公告)号：US20080045727A1

公开(公告)日：2008-02-21

申请号：US11660668

申请日：2005-08-18

申请人： Harry Blaschke ,  Sergiy Pazenok

发明人： Harry Blaschke ,  Sergiy Pazenok

IPC分类号： C07D307/77 ,  C07C63/00

CPC分类号： C07C315/02 ,  C07C319/20 ,  C07C323/42 ,  C07C317/28

摘要： The invention relates to new salts from chiral 3-halophthalic acid derivatives, a method for their production, their use for the production of chiral phthalic acid diamides as well as a new method for the production of chiral phthalic acid diamides.

摘要翻译： 本发明涉及手性3-卤代邻苯二甲酸衍生物的新盐，其制备方法，其用于制备手性邻苯二甲酸二酰胺以及用于生产手性邻苯二甲酸二酰胺的新方法。

公开(公告)号：US20080039663A1

公开(公告)日：2008-02-14

申请号：US11792113

申请日：2005-11-23

申请人： Jorn Stolting ,  Reinhard Lantzsch ,  Sergiy Pazenok

发明人： Jorn Stolting ,  Reinhard Lantzsch ,  Sergiy Pazenok

IPC分类号： C07F15/00

CPC分类号： C07C51/60 ,  C07C63/22

摘要： The invention relates to a novel process for preparing 3-halophthaloyl chlorides (3-halobenzene-1,2-dicarbonyl chlorides) from the corresponding 3-halophthalic anhydrides by reacting with phosgene in the presence of an N,N-dialkylformamide.

摘要翻译： 本发明涉及通过在N，N-二烷基甲酰胺的存在下与光气反应从相应的3-卤代邻苯二甲酸酐制备3-卤代邻苯二酰氯（3-卤代苯-1,2-二羰基氯）的新方法。

公开(公告)号：US20070149780A1

公开(公告)日：2007-06-28

申请号：US11634691

申请日：2006-12-05

申请人： Sergiy Pazenok ,  Mark Ford

发明人： Sergiy Pazenok ,  Mark Ford

IPC分类号： C07D403/02 ,  C07D231/12 ,  C07C251/10

CPC分类号： C07D231/12 ,  C07C249/02 ,  C07D401/04 ,  C07D403/04 ,  C07C251/30

摘要： A process for preparing compounds of the formula (IX) by a) reaction of haloalkyl(thio)acetic acids of the formula (II) with formamides of the formula (III) to give vinimidinium salts of the formula (I), b) reaction of vinimidinium salts of the formula (I) with hydrazines of the formula (V) to give pyrazoles of the formula (IV) c) base-catalyzed reaction of compounds of the formula (VI) with pyrazoles of the formula (IV) to give compounds of the formula (VII) and d) base-catalyzed reaction of compounds of the formula (VII) with compounds of the formula (VIII), in which R1 to R5 are various radicals such as alkyl, X are substituted aromatic radicals such as phenyl, and Z is CH or N.

摘要翻译： a）通过a）式（II）的卤代烷基（硫代）乙酸与式（III）的甲酰胺的反应制备式（Ⅸ）化合物的方法，得到式（I）的脒盐，b）反应 式（Ⅵ）的哒嗪鎓盐与式（Ⅴ）的肼反应得到式（Ⅳ）的吡唑; c）式（Ⅵ）化合物与式（Ⅳ）的吡唑的碱催化反应，得到 式（Ⅶ）化合物和d）式（Ⅶ）化合物与式（Ⅷ）化合物的碱催化反应，其中R 1至R 5， SUP>是各种基团，例如烷基，X是取代的芳族基团，例如苯基，Z是CH或N.

公开(公告)号：US20060276656A1

公开(公告)日：2006-12-07

申请号：US10576742

申请日：2004-10-19

申请人： Reinhard Lantzsch ,  Sergiy Pazenok ,  Frank Memmel

发明人： Reinhard Lantzsch ,  Sergiy Pazenok ,  Frank Memmel

IPC分类号： C07D277/24 ,  C07D231/10

CPC分类号： C07D263/34 ,  C07D231/14 ,  C07D277/30

摘要： The present invention relates to a process for preparing fluoromethyl-substituted heterocycles of the formula (I) in which R1, R2, R3 and A are each as defined in the disclosure, by fluorinating the corresponding chloromethyl-substituted precursors.

摘要翻译： 本发明涉及制备式（I）的氟甲基取代的杂环的方法，其中R 1，R 2，R 3， 和A各自如本公开所定义，通过氟化相应的氯甲基取代的前体。

公开(公告)号：US20060252944A1

公开(公告)日：2006-11-09

申请号：US10576059

申请日：2004-10-12

申请人： Reinhard Lantzsch ,  Wolfgang Jorges ,  Sergiy Pazenok

发明人： Reinhard Lantzsch ,  Wolfgang Jorges ,  Sergiy Pazenok

IPC分类号： C07D231/02 ,  C07C227/16

CPC分类号： C07C229/30 ,  C07D231/14

摘要： The present invention relates to a process for preparing 2-dihaloacyl-3-aminoacrylic esters of the formula (I) characterized in that acid halides of the formula (II) are reacted with dialkylaminoacrylic esters of the formula (III) in which R, R1, R2, X1, X2 and Hal are each as defined in the description in a water-immiscible organic solvent in the presence of a base, to the novel 2-dihaloacyl-3-aminoacrylic esters of the formula (I) themselves, to their use for preparing 3-dihalomethylpyrazoles, to a process for preparing 3-dihalomethylpyrazoles, and also to novel 3-dihalomethylpyrazoles.

摘要翻译： 本发明涉及制备式（I）的2-二卤代-3-氨基丙烯酸酯的方法，其特征在于式（II）的酰卤与式（III）的二烷基氨基丙烯酸酯反应，其中R，R R 1，R 2，X 1，X 2和X 2各自如在描述中所定义的在水中 在碱的存在下，与式（I）本身的新型2-二卤代酰基-3-氨基丙烯酸酯，其用于制备3-二卤代甲基吡唑的方法相比，可用于制备3-二卤代甲基吡唑的方法，以及 到新的3-二卤代甲基吡唑。