-
公开(公告)号：US07179490B2
公开(公告)日：2007-02-20
申请号：US11335283
申请日：2006-01-19
申请人： Francis Xavier Ignatious , Thomas Ciaran Loughman , Shalaby Wahba Shalaby , Franck Jean-Claude Touraud
发明人： Francis Xavier Ignatious , Thomas Ciaran Loughman , Shalaby Wahba Shalaby , Franck Jean-Claude Touraud
CPC分类号： A61K38/08 , A61K9/1647 , A61K9/167 , A61K9/1694 , A61K38/31 , A61K47/593 , A61K47/6927 , Y10T428/2985
摘要： A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
摘要翻译： 一种将含有游离羧基的可生物降解聚合物和游离氨基的药物彼此离子键合的持续释放离子缀合物进行离子化的方法。
-
公开(公告)号：US08614291B2
公开(公告)日：2013-12-24
申请号：US11342209
申请日：2006-01-27
IPC分类号： C07K14/00 , C07K7/06 , A61K38/10 , A61K38/16 , A61K31/765 , A61K31/724
CPC分类号： A61K38/09 , A61K31/724 , A61K31/765 , A61K38/31
摘要： The present invention is directed to absorbable polyesters comprising one or more monophosphate functionality; a conjugate comprising the foregoing polyester and a peptide and/or a bioactive agent; microparticles comprising an absorbable polyester; a conjugate comprising the microparticles and a peptide and/or a bioactive agent; an acylated or alkylated polysaccharide having one or more monophosphate functionality; a conjugate comprising the acylated or alkylated polysaccharide and a peptide and/or a bioactive agent; and pharmaceutical compositions thereof.
摘要翻译： 本发明涉及包含一种或多种单磷酸官能团的可吸收聚酯; 包含上述聚酯和肽和/或生物活性剂的共轭物; 包含可吸收聚酯的微粒; 包含微粒和肽和/或生物活性剂的缀合物; 具有一个或多个单磷酸官能团的酰化或烷基化多糖; 包含酰化或烷基化多糖和肽和/或生物活性剂的缀合物; 及其药物组合物。
-
公开(公告)号：US06911218B2
公开(公告)日：2005-06-28
申请号：US09171740
申请日：1997-04-22
申请人： Francis Xavier Ignatious , Thomas Ciaran Loughman , Shalaby Wahba Shalaby , Franck Jean-Claude Touraud
发明人： Francis Xavier Ignatious , Thomas Ciaran Loughman , Shalaby Wahba Shalaby , Franck Jean-Claude Touraud
IPC分类号： A61K47/34 , A61K9/14 , A61K9/16 , A61K9/26 , A61K9/52 , A61K38/00 , A61K38/22 , A61K47/48 , A61K9/50 , B01J13/02 , B05D7/00 , B32B15/02
CPC分类号： A61K38/08 , A61K9/1647 , A61K9/167 , A61K9/1694 , A61K38/31 , A61K47/593 , A61K47/6927 , Y10T428/2985
摘要： A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
摘要翻译： 一种将含有游离羧基的可生物降解聚合物和游离氨基的药物彼此离子键合的持续释放离子缀合物进行离子化的方法。
-
公开(公告)号：US07026431B2
公开(公告)日：2006-04-11
申请号：US10636357
申请日：2003-08-07
申请人： Francis Xavier Ignatious , Thomas Ciaran Loughman , Shalaby Wahba Shalaby , Franck Jean-Claude Touraud
发明人： Francis Xavier Ignatious , Thomas Ciaran Loughman , Shalaby Wahba Shalaby , Franck Jean-Claude Touraud
IPC分类号： C08G63/02
CPC分类号： A61K38/08 , A61K9/1647 , A61K9/167 , A61K9/1694 , A61K38/31 , A61K47/593 , A61K47/6927 , Y10T428/2985
摘要： A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
-
5.发明授权Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效生物降解聚酯和生物活性多肽的离子分子共轭物公开(公告)号：US06221958B1
公开(公告)日：2001-04-24
申请号：US09237405
申请日：1999-01-26
IPC分类号： A61K916
CPC分类号： C07K7/23 , A61K38/00 , A61K47/593 , C07K14/655 , C08G63/06 , C08G63/08 , C08G63/64 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
摘要翻译： 公开了缓释药物组合物。 所述组合物包括含有游离COOH基团的聚酯，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述组合物中存在的多肽的至少50重量％与所述聚酯离子共轭。
-
6.发明授权Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效生物降解聚酯和生物活性多肽的离子分子共轭物公开(公告)号：US06867181B1
公开(公告)日：2005-03-15
申请号：US09890013
申请日：2000-01-26
CPC分类号： C08G63/64 , A61K47/593 , C07K14/655 , C08G63/08 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other.
摘要翻译： 一种使包含游离含羧基的聚合物和游离氨基的药物彼此离子键合的持续释放离子缀合物的球化方法。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.01 秒)
