公开(公告)号：US08613764B2

公开(公告)日：2013-12-24

申请号：US12023971

申请日：2008-01-31

Applicant: Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

Inventor： Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

IPC: A61F2/82 ,  A61F2/06

CPC classification number: A61F2/07 ,  A61B17/22 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L27/3808 ,  A61L27/3843 ,  A61L31/16 ,  A61M25/0084 ,  A61M29/02 ,  A61M2025/0086

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。

公开(公告)号：US20110229548A1

公开(公告)日：2011-09-22

申请号：US12727175

申请日：2010-03-18

Applicant: Florencia Lim ,  Shawn Chin Quee ,  Mikael O. Trollsas

Inventor： Florencia Lim ,  Shawn Chin Quee ,  Mikael O. Trollsas

IPC: A61F2/82 ,  A61K31/436 ,  A61F2/06

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2420/08 ,  C08L27/20 ,  C08L27/16

Abstract: This invention relates to an implantable medical device for and method of treating a vascular disease where the device is preferably a stent comprising a drug reservoir layer comprising poly(vinylidene fluoride-co-hexafluoropropylene) and zotarolimus.

Abstract translation: 本发明涉及一种用于治疗血管疾病的可植入医疗装置及其方法，其中装置优选为支架，其包括含有聚（偏二氟乙烯 - 共 - 六氟丙烯）和佐他莫司的药物储存层。

公开(公告)号：US07326238B1

公开(公告)日：2008-02-05

申请号：US10262149

申请日：2002-09-30

Applicant: Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

Inventor： Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61B17/22 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L27/3808 ,  A61L27/3843 ,  A61L31/16 ,  A61M25/0084 ,  A61M29/02 ,  A61M2025/0086

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。

公开(公告)号：US08652194B1

公开(公告)日：2014-02-18

申请号：US11388899

申请日：2006-03-23

Applicant: Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

Inventor： Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

IPC: A61F2/82

CPC classification number: A61F2/07 ,  A61B17/22 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L27/3808 ,  A61L27/3843 ,  A61L31/16 ,  A61M25/0084 ,  A61M29/02 ,  A61M2025/0086

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。

公开(公告)号：US20080125851A1

公开(公告)日：2008-05-29

申请号：US12023971

申请日：2008-01-31

Applicant: Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

Inventor： Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

IPC: A61F2/82 ,  A61F2/92 ,  A61M25/00

CPC classification number: A61F2/07 ,  A61B17/22 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L27/3808 ,  A61L27/3843 ,  A61L31/16 ,  A61M25/0084 ,  A61M29/02 ,  A61M2025/0086

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。