公开(公告)号：US6086877A

公开(公告)日：2000-07-11

申请号：US810593

申请日：1997-03-04

申请人： Kusuki Nishioka ,  Shin Yonehara

发明人： Kusuki Nishioka ,  Shin Yonehara

IPC分类号： A61K38/00 ,  A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2878 ,  A61K39/3955 ,  A61K38/00 ,  C07K2317/73

摘要： The present invention relates to a therapeutic agent for rheumatic disease comprising an anti-Fas monoclonal antibody, or the combination of an anti-Fas monoclonal antibody and a medical substance having an inhibitory effect of cell proliferation as an active ingredient. The anti-Fas monoclonal antibody of this invention reacts with the Fas antigen in synovial cells of patients with rheumatoid arthritis, especially the human Fas antigen specifically and expresses apoptosis on synovial cells.

摘要翻译： 本发明涉及一种包含抗Fas单克隆抗体或抗Fas单克隆抗体与具有细胞增殖抑制作用的药物的组合作为活性成分的风湿病治疗剂。 本发明的抗Fas单克隆抗体与类风湿性关节炎患者，特别是人Fas抗原的滑膜细胞中的Fas抗原反应，并在滑膜细胞上表达细胞凋亡。

公开(公告)号：US06972323B1

公开(公告)日：2005-12-06

申请号：US09499662

申请日：2000-02-09

申请人： Nobufusa Serizawa ,  Kimihisa Ichikawa ,  Jun Ohsumi ,  Masahiko Ohtsuki ,  Hideyuki Haruyama ,  Tohru Takahashi ,  Hiroko Yoshida ,  Akio Shiraishi ,  Shin Yonehara

发明人： Nobufusa Serizawa ,  Kimihisa Ichikawa ,  Jun Ohsumi ,  Masahiko Ohtsuki ,  Hideyuki Haruyama ,  Tohru Takahashi ,  Hiroko Yoshida ,  Akio Shiraishi ,  Shin Yonehara

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/70575 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

摘要： Anti-Fas antibodies which are cross-reactive with mouse and human Fas and are useful in the treatment of conditions attributable to abnormalities in the Fas/Fas ligand system.

摘要翻译： 抗Fas抗体与小鼠和人Fas交叉反应，可用于治疗归因于Fas / Fas配体系统异常的病症。

公开(公告)号：US06270998B1

公开(公告)日：2001-08-07

申请号：US08468560

申请日：1995-06-06

申请人： Shigekazu Nagata ,  Naoto Itoh ,  Shin Yonehara

发明人： Shigekazu Nagata ,  Naoto Itoh ,  Shin Yonehara

IPC分类号： C12N1512

CPC分类号： C07K14/715 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/73

摘要： DNAs coding for human cell surface antigen (Fas or Fas antigen), vectors for expressing for said DNAs and transformants transfected with said vector are proveded. Fas is a polypeptide that exists in the surfaces of a variety of cells and is considered to be deeply concerned with the apoptosis of cells. The isolated Fas CDNA has an open reading frame that is capable of encoding a protein consisting of 335 amino acids. The mature Fas antigen is a protein consisting of 319 amino acids having a calculated molecular weight of about 36,000 and is constituted by an extracellular domain of 157 amino acids, a membrane-spanning domain of 17 amino acids, and a cytoplasmic domain of 145 amino acids.

摘要翻译： 证明编码人细胞表面抗原（Fas或Fas抗原）的DNA，用于表达所述DNA的载体和用所述载体转染的转化体。 Fas是存在于多种细胞表面的多肽，被认为与细胞凋亡密切相关。分离的Fas CDNA具有能够编码由335个氨基酸组成的蛋白质的开放阅读框。 成熟的Fas抗原是由319个氨基酸组成的蛋白质，其计算分子量约为36,000，由157个氨基酸的胞外结构域，17个氨基酸的跨膜结构域和145个氨基酸的胞质结构域 。

公开(公告)号：US06949360B2

公开(公告)日：2005-09-27

申请号：US09884987

申请日：2001-06-21

申请人： Shigekazu Nagata ,  Naoto Itoh ,  Shin Yonehara

发明人： Shigekazu Nagata ,  Naoto Itoh ,  Shin Yonehara

IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C12N1/21 ,  C12N15/12 ,  C12P21/08 ,  C07H21/04 ,  C12N15/63

CPC分类号： C07K14/715 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/73

摘要： DNAs coding for human cell surface antigen (Fas or Fas antigen), vectors for expressing for said DNAs and transformants transfected with said vector are proveded. Fas is a polypeptide that exists in the surfaces of a variety of cells and is considered to be deeply concerned with the apoptosis of cells. The isolated Fas cDNA has an open reading frame that is capable of encoding a protein consisting of 335 amino acids. The mature Fas antigen is a protein consisting of 319 amino acids having a calculated molecular weight of about 36,000 and is constituted by an extracellular domain of 157 amino acids, a membrane-spanning domain of 17 amino acids, and a cytoplasmic domain of 145 amino acids.

摘要翻译： 证明编码人细胞表面抗原（Fas或Fas抗原）的DNA，用于表达所述DNA的载体和用所述载体转染的转化体。 Fas是存在于多种细胞表面的多肽，被认为是深入关注细胞的凋亡。 分离的Fas cDNA具有能够编码由335个氨基酸组成的蛋白质的开放阅读框。 成熟的Fas抗原是由319个氨基酸组成的蛋白质，其计算分子量约为36,000，由157个氨基酸的胞外结构域，17个氨基酸的跨膜结构域和145个氨基酸的胞质结构域 。

公开(公告)号：US5874546A

公开(公告)日：1999-02-23

申请号：US219237

申请日：1994-03-28

申请人： Shigekazu Nagata ,  Naoto Itoh ,  Shin Yonehara

发明人： Shigekazu Nagata ,  Naoto Itoh ,  Shin Yonehara

IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C12N1/21 ,  C12N15/12 ,  C12P21/08 ,  C07K14/475 ,  C07K14/435

CPC分类号： C07K14/715 ,  C07K16/2878 ,  A61K38/00 ,  C07K2317/73

摘要： DNAs coding for human cell surface antigen (Fas or Fas antigen), vectors for expressing for said DNAs and transformants transfected with said vector are provided. Fas is a polypeptide that exists in the surfaces of a variety of cells and is considered to be deeply concerned with the apoptosis of cells. The isolated Fas cDNA has an open reading frame that is capable of encoding a protein consisting of 335 amino acids. The mature Fas antigen is a protein consisting of 319 amino acids having a calculated molecular weight of about 36,000 and is constituted by an extracellular domain of 157 amino acids, a membrane-spanning domain of 17 amino acids, and a cytoplasmic domain of 145 amino acids.

摘要翻译： 提供编码人细胞表面抗原（Fas或Fas抗原）的DNA，用于表达所述DNA的载体和用所述载体转染的转化体。 Fas是存在于多种细胞表面的多肽，被认为是深入关注细胞的凋亡。 分离的Fas cDNA具有能够编码由335个氨基酸组成的蛋白质的开放阅读框。 成熟的Fas抗原是由319个氨基酸组成的蛋白质，其计算分子量约为36,000，由157个氨基酸的胞外结构域，17个氨基酸的跨膜结构域和145个氨基酸的胞质结构域 。