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1.发明授权
公开(公告)号：US5164840A
公开(公告)日：1992-11-17
申请号：US400190
申请日：1989-08-28
申请人： Akihisa Kawamura , Masaharu Matsumoto , Mitsuhiko Serikawa , Ryo Tagami , Katsuaki Sato , Hiroko Yoshida , Hikari Hashimoto
发明人： Akihisa Kawamura , Masaharu Matsumoto , Mitsuhiko Serikawa , Ryo Tagami , Katsuaki Sato , Hiroko Yoshida , Hikari Hashimoto
CPC分类号： G11B20/00992 , G11B27/007 , G11B27/107 , G11B27/322 , G11B27/34 , H04N9/802 , H04S1/007
摘要： Control codes for controlling processing of an audio signal by a sound field variation circuit to produce desired sound fields are recorded on a monaural track of a video tape concurrent with recording of video and audio signals, and can thereby be subsequently played back for producing sound fields which are respectively synchronized with video images.
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公开(公告)号：US5144673A
公开(公告)日：1992-09-01
申请号：US623619
申请日：1990-12-07
摘要： A reflection sound compression apparatus extracts and compresses, most appropriately with a physical evaluation value, an impulse response of a hall, etc. which is obtained by calculation and actual experiments to reflection sounds in a number required by a sound field controller by using a learning identification method.
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公开(公告)号：US09127070B2
公开(公告)日：2015-09-08
申请号：US13881645
申请日：2011-10-27
申请人： Toshiaki Ohtsuka , Takeshi Takizawa , Akiko Oguni , Tatsuji Matsuoka , Hiroko Yoshida , Yumi Matsui
发明人： Toshiaki Ohtsuka , Takeshi Takizawa , Akiko Oguni , Tatsuji Matsuoka , Hiroko Yoshida , Yumi Matsui
IPC分类号： A61K39/395 , C12N5/10 , C12N15/13 , C07K16/28 , C07K16/30 , C07K14/705 , A61K31/337 , A61K31/4745 , A61K31/475 , A61K31/555 , A61K31/439 , A61K31/4545 , A61K31/513 , A61K39/00
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/439 , A61K31/4545 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/555 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/70578 , C07K16/30 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/73 , C07K2317/92 , C07K2319/30 , A61K2300/00
摘要： The present invention relates to an antibody which has a therapeutic effect on cancer, an autoimmune disease, or an inflammatory disease. That is, the present invention relates to an antibody which exhibits a cytotoxic activity against death domain-containing receptor-expressing cells through apoptosis.[Object]An object of the invention is to provide a pharmaceutical having a therapeutic effect on cancer.[Means for Resolution]A novel anti-DR5 antibody capable of inducing apoptosis in cells has more potent cytotoxic activity than currently available anti-DR5 antibodies.
摘要翻译： 本发明涉及对癌症，自身免疫性疾病或炎性疾病具有治疗作用的抗体。 也就是说，本发明涉及通过凋亡显示对含有表达死亡结构域的受体表达细胞的细胞毒性活性的抗体。 本发明的目的是提供对癌症具有治疗作用的药物。 [解决方法]能够诱导细胞凋亡的新型抗DR5抗体比目前可用的抗DR5抗体具有更强的细胞毒性活性。
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公开(公告)号：US20140004120A1
公开(公告)日：2014-01-02
申请号：US13881645
申请日：2011-10-27
申请人： Toshiaki Ohtsuka , Takeshi Takizawa , Akiko Oguni , Tatsuji Matsuoka , Hiroko Yoshida , Yumi Matsui
发明人： Toshiaki Ohtsuka , Takeshi Takizawa , Akiko Oguni , Tatsuji Matsuoka , Hiroko Yoshida , Yumi Matsui
IPC分类号： C07K16/30 , A61K31/439 , A61K39/395 , A61K31/555 , A61K31/513 , A61K31/337 , A61K31/4545
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/439 , A61K31/4545 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/555 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/70578 , C07K16/30 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/73 , C07K2317/92 , C07K2319/30 , A61K2300/00
摘要： The present invention relates to an antibody which has a therapeutic effect on cancer, an autoimmune disease, or an inflammatory disease. That is, the present invention relates to an antibody which exhibits a cytotoxic activity against death domain-containing receptor-expressing cells through apoptosis.[Object]An object of the invention is to provide a pharmaceutical having a therapeutic effect on cancer.[Means for Resolution]A novel anti-DR5 antibody capable of inducing apoptosis in cells has more potent cytotoxic activity than currently available anti-DR5 antibodies.
摘要翻译： 本发明涉及对癌症，自身免疫性疾病或炎性疾病具有治疗作用的抗体。 也就是说，本发明涉及通过凋亡显示对含有表达死亡结构域的受体表达细胞的细胞毒性活性的抗体。 本发明的目的是提供对癌症具有治疗作用的药物。 [解决方法]能够诱导细胞凋亡的新型抗DR5抗体比目前可用的抗DR5抗体具有更强的细胞毒性活性。
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公开(公告)号：US20110269942A1
公开(公告)日：2011-11-03
申请号：US12672861
申请日：2008-08-04
申请人： Koji Morita , Takako Niwa , Yuji Kasuya , Kimihisa Ichikawa , Hiroko Yoshida
发明人： Koji Morita , Takako Niwa , Yuji Kasuya , Kimihisa Ichikawa , Hiroko Yoshida
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K9/127 , A61K47/6913 , C07K2317/73
摘要： The present invention relates to an immunoliposome preparation or a hydrophobic molecule-modified antibody having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome or a hydrophobic molecule-modified antibody comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.
摘要翻译： 本发明涉及具有对癌症，自身免疫疾病或炎性疾病的治疗作用的免疫脂质体制剂或疏水性分子修饰抗体。 具体地说，本发明涉及一种免疫脂质体或疏水性分子修饰抗体，其包含能够诱导表达含有死亡结构域的受体的细胞凋亡的抗体作为组分。
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公开(公告)号：US20110070248A1
公开(公告)日：2011-03-24
申请号：US12889306
申请日：2010-09-23
申请人： Kimihisa Ichikawa , Kosaku Fujiwara , Hiroko Yoshida , Ayumi Yada
发明人： Kimihisa Ichikawa , Kosaku Fujiwara , Hiroko Yoshida , Ayumi Yada
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00
CPC分类号： C07K16/2878 , A61K47/6803 , A61K47/6849 , C07K2319/30
摘要： Ligand Drug Conjugates are provided having a DR5 binding moiety attached via linking groups and/or spacers to a therapeutic agent and are effective in treatment of various cancers.
摘要翻译： 配体药物缀合物具有通过连接基团和/或间隔基与治疗剂连接的DR5结合部分并且有效治疗各种癌症。
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7.发明申请IMMUNOLIPOSOME INDUCING APOPTOSIS INTO CELL EXPRESSING DEATH DOMAIN-CONTAINING RECEPTOR 审中-公开免疫球蛋白诱导凋亡进入细胞表达死亡含域受体公开(公告)号：US20100209490A1
公开(公告)日：2010-08-19
申请号：US12672870
申请日：2008-08-04
申请人： Koji Morita , Takako Niwa , Kimihisa Ichikawa , Hiroko Yoshida
发明人： Koji Morita , Takako Niwa , Kimihisa Ichikawa , Hiroko Yoshida
IPC分类号： A61K9/127 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2878 , A61K9/127 , A61K47/6913 , C07K2317/73
摘要： The present invention relates to an immunoliposome preparation having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.
摘要翻译： 本发明涉及具有对癌症，自身免疫疾病或炎性疾病的治疗作用的免疫脂质体制剂。 具体地，本发明涉及包含能够诱导表达含有死亡结构域的受体的细胞凋亡的抗体作为组分的免疫脂质体。
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8.发明申请CELL ACTIVATOR, COLLAGEN PRODUCTION PROMOTER, SKIN WHITENING AGENT, ANTIOXIDANT AGENT, ANTIINFLAMMATORY AGENT, AROMATASE ACTIVITY PROMOTER, PROTEASE ACTIVITY PROMOTER, EXTERNAL PREPARATION FOR SKIN, AND FOOD 有权细胞活化剂，胶原蛋白生产促进剂，皮肤白化剂，抗氧化剂，抗炎剂，芳香酶活性促进剂，蛋白酶活性促进剂，皮肤外用制剂和食品公开(公告)号：US20090280197A1
公开(公告)日：2009-11-12
申请号：US12373725
申请日：2007-09-04
IPC分类号： A61K36/00
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K2800/522 , A61Q19/02 , A61Q19/08 , A23V2250/21
摘要： The present invention provides a cell activation agent, a collagen production accelerator, a whitening agent, an antioxidant, an anti-inflammatory agent, an aromatase activity accelerator, a protease activity accelerator, a skin external preparation, and food, which all contain an extract of Hibiscus makinoi.
摘要翻译： 本发明提供一种细胞活化剂，胶原产生促进剂，增白剂，抗氧化剂，抗炎剂，芳香酶活性促进剂，蛋白酶活性促进剂，皮肤外用剂和食品，它们都含有提取物 的木槿。
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公开(公告)号：US5073942A
公开(公告)日：1991-12-17
申请号：US645476
申请日：1991-01-24
CPC分类号： G10H1/0091 , G10H2210/301 , Y10S84/26
摘要： A sound field switcher inputs an output sound field signal from a sound field producer. The inputted sound field signal is delayed sequentially by plural delayers, after which they are multiplied by coefficients by plural multipliers, and the multiplied results are all added by an adder. Coefficients stored in an area of a memory indicated by a coefficient counter are read out and set to the plural multipliers. The sound field switcher carries out control of the timing for switching the sound field signal produced by the sound field producer and the timing for the coefficient counter to commence counting. Assuming the time required for switching the sound field to be N sampling periods, in case of carrying out a sound field switching from a sound field A to a sound field B, a sound field switching controller issues an order to the coefficient counter so as to count up one by one from 0 to N, and on each count the coefficients stored in an area of the coefficient memory is set to the multipliers. When the count value of the coefficient counter comes to (N/2) or nearest to (N/2), the sound field switching controller issues an order to the sound field producer to output the sound field signal of the sound field B. When the count value of the coefficient counter comes to N, the switching from the sound field A to the sound field B is completed.
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10.发明授权Cell activator, collagen production promoter, skin whitening agent, antioxidant agent, antiinflammatory agent, aromatase activity promoter, protease activity promoter, external preparation for skin, and food 有权细胞活化剂，胶原蛋白生成促进剂，皮肤增白剂，抗氧化剂，抗炎剂，芳香酶活性促进剂，蛋白酶活性促进剂，皮肤外用剂和食品公开(公告)号：US07794759B2
公开(公告)日：2010-09-14
申请号：US12373725
申请日：2007-09-04
IPC分类号： A61K36/00
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K2800/522 , A61Q19/02 , A61Q19/08 , A23V2250/21
摘要： The present invention provides a cell activation agent, a collagen production accelerator, a whitening agent, an antioxidant, an anti-inflammatory agent, an aromatase activity accelerator, a protease activity accelerator, a skin external preparation, and food, which all contain an extract of Hibiscus makinoi.
摘要翻译： 本发明提供一种细胞活化剂，胶原产生促进剂，增白剂，抗氧化剂，抗炎剂，芳香酶活性促进剂，蛋白酶活性促进剂，皮肤外用剂和食品，它们都含有提取物 的木槿。
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