公开(公告)号：US06511845B1

公开(公告)日：2003-01-28

申请号：US09618360

申请日：2000-07-18

申请人： Alan R. Davis ,  Paul P. Hung ,  Michael D. Lubeck ,  Robert J. Natuk ,  Pranab K. Chanda ,  Shridhara C. S. Murthy ,  Shaw-Guang L. Lee

发明人： Alan R. Davis ,  Paul P. Hung ,  Michael D. Lubeck ,  Robert J. Natuk ,  Pranab K. Chanda ,  Shridhara C. S. Murthy ,  Shaw-Guang L. Lee

IPC分类号： A61K3921

CPC分类号： C12N15/86 ,  A61K39/00 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  Y02A50/464 ,  Y02A50/472

摘要： This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises administering to said primate intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Preferably, the infectious organism is HIV and the primate is a human.

摘要翻译： 本发明提供了通过刺激产生抗体或细胞介导的对感染性生物的免疫来保护灵长类从感染性生物体的方法，其包括向所述灵长类动物鼻内，肌内或皮下施用病毒结构蛋白质的活重组腺病毒 与从其产生重组腺病毒的天然腺病毒中不同，并且其含有编码对应于所述抗体的抗原的基因或诱导所述细胞介导的免疫。 优选地，感染性生物是HIV，灵长类是人。