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公开(公告)号：US06511845B1
公开(公告)日：2003-01-28
申请号：US09618360
申请日：2000-07-18
申请人： Alan R. Davis , Paul P. Hung , Michael D. Lubeck , Robert J. Natuk , Pranab K. Chanda , Shridhara C. S. Murthy , Shaw-Guang L. Lee
发明人： Alan R. Davis , Paul P. Hung , Michael D. Lubeck , Robert J. Natuk , Pranab K. Chanda , Shridhara C. S. Murthy , Shaw-Guang L. Lee
IPC分类号： A61K3921
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , Y02A50/464 , Y02A50/472
摘要： This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises administering to said primate intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Preferably, the infectious organism is HIV and the primate is a human.
摘要翻译： 本发明提供了通过刺激产生抗体或细胞介导的对感染性生物的免疫来保护灵长类从感染性生物体的方法，其包括向所述灵长类动物鼻内，肌内或皮下施用病毒结构蛋白质的活重组腺病毒 与从其产生重组腺病毒的天然腺病毒中不同，并且其含有编码对应于所述抗体的抗原的基因或诱导所述细胞介导的免疫。 优选地，感染性生物是HIV，灵长类是人。
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公开(公告)号：US5591823A
公开(公告)日：1997-01-07
申请号：US169813
申请日：1993-12-17
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/16 , A61P37/08 , C07H21/00 , C07K14/11 , C07K14/16 , C12N7/01 , C12N15/08 , C12N15/09 , C12N15/11 , C12N15/32 , C12N15/34 , C12N15/44 , C12P21/02 , G01N33/53 , G01N33/569 , C07K1/00 , A61K39/145 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/40 , C12N2740/16022 , C12N2760/16122
摘要： Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigenic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immunotherapy.
摘要翻译： 提供了嵌合DNA片段，其包括与编码具有5个免疫显性抗原位点的甲型流感病毒的HA表面蛋白基本上相同的核苷酸序列，其中插入与编码外源表位的碱基序列基本相同的核苷酸序列 进入抗原位点的核苷酸序列。 也提供相应的嵌合肽，表达载体和转化的宿主。 这些肽可用于提供针对相应抗原和测试试剂盒的疫苗以检测对这些抗原的暴露。 此外，这些肽或其相应的抗体可用于治疗和预防暴露于这些抗原的表现的方法，包括免疫治疗。
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公开(公告)号：US5376547A
公开(公告)日：1994-12-27
申请号：US150267
申请日：1988-01-29
IPC分类号： C12N9/64 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/02 , C12N9/72 , C12N15/09 , C12N9/48 , A61K37/547
CPC分类号： C12N9/6456
摘要： Des-epidermal growth factor homologous--plasminogen activators with greatly diminished affinity for liver membranes.
摘要翻译： 去皮表皮生长因子同源纤溶酶原激活剂，对肝膜的亲和力大大降低。
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公开(公告)号：US4997766A
公开(公告)日：1991-03-05
申请号：US436528
申请日：1989-11-14
CPC分类号： C12N9/6456 , C12N15/85 , C07K2319/00
摘要： Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators. Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.
摘要翻译： 通过重组DNA技术制备的含有复数个异源多肽三聚体的混合第三代纤溶酶原激活剂以及编码活化剂的基因。 公开了含有这些基因的载体和使用纤溶酶原激活剂作为溶栓剂的方法。
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公开(公告)号：US4916071A
公开(公告)日：1990-04-10
申请号：US884835
申请日：1986-07-11
IPC分类号： C12N15/09 , A61K20060101 , A61K35/12 , A61K35/74 , A61K38/00 , A61K38/46 , A61K48/00 , A61P7/02 , C07H20060101 , C07H21/04 , C07K20060101 , C07K14/745 , C12N9/48 , C12N9/52 , C12N9/64 , C12N9/72 , C12N15/00 , C12N15/58 , C12R1/19
CPC分类号： C12N9/6456 , C07K2319/00
摘要： Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.
摘要翻译： 公开了包含通过重组DNA技术制备的复数个异源多肽三聚体以及编码活化剂的基因，含有这些基因的载体和使用纤溶酶原激活剂作为溶栓剂的方法的混合第三代纤溶酶原激活剂。
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公开(公告)号：US5047241A
公开(公告)日：1991-09-10
申请号：US140068
申请日：1987-12-31
CPC分类号： C12N9/6459 , C12N15/85 , C12N9/6456 , C12Y304/21069 , A61K38/00 , C07K2319/00
摘要： Tris-Kringle plasminogen activators containing an additional second kringle domain or an additional modified second kringle domain are useful in disrupting blood clots.
摘要翻译： 含有额外的第二kringle结构域或另外修饰的第二kringle结构域的Tris-Kringle纤溶酶原激活物可用于破坏血块。
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7.发明授权Process for treating thrombosis by administering poly-kringle plasminogen activator 失效通过施用聚多克隆纤溶酶原激活剂治疗血栓形成的方法
公开(公告)号：US5045315A
公开(公告)日：1991-09-03
申请号：US601542
申请日：1990-10-23
CPC分类号： C12N9/6456 , C12N15/85 , C07K2319/00
摘要： Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.
摘要翻译： 公开了含有通过重组DNA技术制备的复数个异源多肽三聚体以及编码活化剂的基因，含有这些基因的载体和使用纤溶酶原激活剂作为溶栓剂的方法的混合第三代纤溶酶原激活剂。
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公开(公告)号：US4920209A
公开(公告)日：1990-04-24
申请号：US58002
申请日：1987-06-04
申请人： Alan R. Davis , Paul P. Hung
发明人： Alan R. Davis , Paul P. Hung
IPC分类号： A61K20060101 , A61K39/00 , A61K39/12 , A61K39/235 , A61K39/29 , C07K14/02 , C07K14/075 , C07K14/14 , C07K14/16 , C12N20060101 , C12N15/00 , C12N15/861
CPC分类号： C12N15/86 , A61K39/00 , C12N2710/10322 , C12N2710/10343 , C12N2720/12322 , C12N2720/12334 , C12N2730/10134
摘要： Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.
摘要翻译： 描述了用于产生感染性生物体的抗体的方法和疫苗。 含有编码另一感染性生物体产生的抗原的外源基因的活重组腺病毒以肠溶包被的剂型递送至温血动物的肠道，于是病毒感染肠壁并诱导产生抗体或细胞 介导的对腺病毒和其他感染性生物体的免疫。
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9.发明授权Deoxyribonucleic acid synthesis using binding protein extracted from chick embryo fibroblasts 失效使用从鸡胚成纤维细胞提取的结合蛋白的脱氧核糖核酸合成
公开(公告)号：US4331589A
公开(公告)日：1982-05-25
申请号：US254726
申请日：1981-04-16
申请人： Paul P. Hung , Shaw-Guang Lee
发明人： Paul P. Hung , Shaw-Guang Lee
CPC分类号： C12P19/34 , C12N15/1096 , Y10S530/808 , Y10S530/821 , Y10S530/826
摘要： Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.
摘要翻译： 描述了通过使用结合蛋白的逆转录获得将全长的单链核糖核酸（RNA）完全复制到其互补的脱氧核糖核酸（cDNA）中的方法。 该方法可用于重组DNA研究，将总信使RNA复制到DNA中。
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公开(公告)号：US3979511A
公开(公告)日：1976-09-07
申请号：US472564
申请日：1974-05-23
IPC分类号： A61K31/71
CPC分类号： A61K31/70
摘要： A method of inhibiting the activity of reverse transcriptase in Rous sarcoma viruses and other viruses containing reverse transcriptase. The method comprises subjecting the reverse transcriptase to an enzyme inhibiting effective dosage of a compound of the formula: ##SPC1##Wherein R' is hydrogen or hydroxyl and R is C.sub.1 -C.sub.8 alkyl, cyclohexyl, phenyl, benzyl, and substituted benzyl.
摘要翻译： 一种抑制罗氏肉瘤病毒和含有逆转录酶的其他病毒中逆转录酶活性的方法。 该方法包括使逆转录酶经受酶抑制有效剂量的下式化合物：
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