BCR-ABL imatinib resistance-associated peptides and methods of use thereof
    2.
    发明申请
    BCR-ABL imatinib resistance-associated peptides and methods of use thereof 审中-公开
    BCR-ABL伊马替尼耐药相关肽及其使用方法

    公开(公告)号:US20060153861A1

    公开(公告)日:2006-07-13

    申请号:US11237939

    申请日:2005-09-29

    CPC分类号: C07K14/82 A61K38/08

    摘要: The present invention is directed to immunogenic peptides, compositions and vaccines comprising same, and methods of use thereof for treating, inhibiting or reducing the incidence of a cancer associated with an activated kinase, and methods of generating a heteroclitic immune response against, or cytotoxic T cells specifically recognizing cancer cells which are associated with an activated kinase.

    摘要翻译: 本发明涉及包含其的免疫原性肽,组合物和疫苗及其用于治疗,抑制或降低与活化的激酶相关的癌症发生率的用途的方法,以及产生针对或细胞毒性T的异型细胞免疫应答的方法 特异性识别与活化的激酶相关的癌细胞的细胞。

    Synthetic HLA binding peptide analogues and uses thereof
    3.
    发明申请
    Synthetic HLA binding peptide analogues and uses thereof 有权
    合成HLA结合肽类似物及其用途

    公开(公告)号:US20050119185A1

    公开(公告)日:2005-06-02

    申请号:US10999425

    申请日:2004-11-30

    摘要: The present invention provides synthetic peptides comprising at least analogues of a native peptide that specifically bind to HLA A0201 or HLA A0301 molecules on a cell characteristic of a pathophysiologic state, such as a cancer cell, in a mammal. Also provided are pharmaceutical compositions and immunogenic compositions comprising at least the peptide analogue segments or a DNA encoding the same. Also provided are methods of using the synthetic peptides and immunogenic compositions to induce a heteroclitic immune response or to treat a cancer.

    摘要翻译: 本发明提供了至少包含在哺乳动物的病理生理状态特征如癌细胞的细胞上特异性结合HLA A0201或HLA A0301分子的天然肽的类似物的合成肽。 还提供了药物组合物和至少包含肽类似物片段或其编码的DNA的免疫原性组合物。 还提供了使用合成肽和免疫原性组合物诱导杂交免疫应答或治疗癌症的方法。

    Synthetic HLA binding WT-1 peptide analogues and uses thereof
    4.
    发明授权
    Synthetic HLA binding WT-1 peptide analogues and uses thereof 有权
    合成HLA结合WT-1肽类似物及其用途

    公开(公告)号:US07598221B2

    公开(公告)日:2009-10-06

    申请号:US11223139

    申请日:2005-09-12

    IPC分类号: A61K38/10

    摘要: The present invention is directed to a synthetic peptide comprising a sequence of amino acids containing at least a segment that is an analogue of a native peptide that specifically binds to HLA A0201 or HLA A0301 molecules on a cell characteristic of a pathophysiologic state in a mammal. The synthetic peptide may be derived from native peptides comprising a breakpoint region of the WT1 protein.

    摘要翻译: 本发明涉及一种合成肽,其包含氨基酸序列,所述氨基酸序列至少包含与哺乳动物的病理生理状态特征的细胞上特异性结合HLA A0201或HLA A0301分子的天然肽的类似物。 合成肽可以衍生自包含WT1蛋白的断点区的天然肽。

    Synthetic HLA binding peptide analogues and uses thereof
    5.
    发明申请
    Synthetic HLA binding peptide analogues and uses thereof 审中-公开
    合成HLA结合肽类似物及其用途

    公开(公告)号:US20060134129A1

    公开(公告)日:2006-06-22

    申请号:US11238128

    申请日:2005-09-29

    IPC分类号: A61K48/00 A61K39/00 A61K38/10

    摘要: The present invention is directed to immunogenic bcr-abl-based peptides, compositions and vaccines comprising same, and methods of use thereof for treating, inhibiting or reducing the incidence of a bcr-abl-expressing cancer, and methods of generating a heteroclitic immune response against, or cytotoxic T cells specifically recognizing bcr-abl-expressing cancer cells.

    摘要翻译: 本发明涉及基于免疫原性bcr-abl的肽,包含其的组合物和疫苗及其用于治疗,抑制或降低表达bcr-abl的癌症的发生率的方法,以及产生杂交免疫应答的方法 抗原或细胞毒性T细胞,特异性识别表达bcr-abl的癌细胞。

    Synthetic HLA binding WT-1 peptide analogues and uses thereof
    6.
    发明申请
    Synthetic HLA binding WT-1 peptide analogues and uses thereof 有权
    合成HLA结合WT-1肽类似物及其用途

    公开(公告)号:US20060084609A1

    公开(公告)日:2006-04-20

    申请号:US11223139

    申请日:2005-09-12

    IPC分类号: A61K38/08 C07K7/06

    摘要: The present invention is directed to a synthetic peptide comprising a sequence of amino acids containing at least a segment that is an analogue of a native peptide that specifically binds to HLA A0201 or HLA A0301 molecules on a cell characteristic of a pathophysiologic state in a mammal. The synthetic peptide may be derived from native peptides comprising a breakpoint region of the WTI protein.

    摘要翻译: 本发明涉及一种合成肽,其包含氨基酸序列,所述氨基酸序列至少包含与哺乳动物的病理生理状态特征的细胞上特异性结合HLA A0201或HLA A0301分子的天然肽的类似物。 合成肽可以衍生自包含WTI蛋白的断点区的天然肽。