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1.发明申请公开(公告)号：US20130302868A1
公开(公告)日：2013-11-14
申请号：US13701247
申请日：2011-05-31
摘要： The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise one or more modifications resulting in the reduction in the expression and/or activity of an endogenous transporter protein. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces Glade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译： 本发明涉及包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。 在本发明的各个方面，重组微生物可包含导致内源转运蛋白的表达和/或活性降低的一种或多种修饰。 在本文所述的各种实施方案中，重组微生物可以是葡萄糖酵母的微生物，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，前WGD（全基因组复制）酵母微生物 ，和非发酵酵母微生物。
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2.发明申请公开(公告)号：US20170183612A1
公开(公告)日：2017-06-29
申请号：US15348576
申请日：2016-11-10
CPC分类号： C12C11/003 , C12C7/205 , C12C7/287 , C12C12/006 , C12C12/04
摘要： It has unexpectedly been found that Pichia spp. strains have advantageous properties useful in the beer fermentation process. In particular, Pichia spp. yeast strains can be combined with normal beer yeast strains and different hop varieties in a fermentation process to produce synergistic effects—namely, the increased production of esters in the fermentation product. More specifically, the yeast can be used to produce increased levels of isoamyl acetate, isobutyl acetate, ethyl propionate, ethyl valerate, ethyl butyrate, ethyl decanoate and ethyl octanoate in beer. In addition, the Pichia spp. strain interacts differently with different hop varieties, so the flavor profile of beer can be tuned by using different combinations of Pichia spp. strains and hops. The present invention relates to a method of brewing beer using a Pichia spp. yeast strain and at least one hop variety, a beer obtainable by such a method and use of a Pichia spp. yeast strain according to the present invention.
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3.发明授权公开(公告)号：US09249420B2
公开(公告)日：2016-02-02
申请号：US13701247
申请日：2011-05-31
申请人： Catherine Asleson Dundon , Christopher Smith , Piruz Nahreini , Johan Thevelein , Sofie Saerens
发明人： Catherine Asleson Dundon , Christopher Smith , Piruz Nahreini , Johan Thevelein , Sofie Saerens
IPC分类号： C12P7/16 , C12N15/81 , C12N1/00 , C07K14/395
摘要： The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise one or more modifications resulting in the reduction in the expression and/or activity of an endogenous transporter protein. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译： 本发明涉及包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。 在本发明的各个方面，重组微生物可包含导致内源转运蛋白的表达和/或活性降低的一种或多种修饰。 在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物 ，和非发酵酵母微生物。
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