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1.发明申请公开(公告)号：US20090042893A1
公开(公告)日：2009-02-12
申请号：US12188515
申请日：2008-08-08
申请人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Dennis S. Rice , Michael Victor Voronkov , Yulian Zhang
发明人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Dennis S. Rice , Michael Victor Voronkov , Yulian Zhang
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/497 , A61P27/02
CPC分类号： C07D487/04 , C07D519/00
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use.
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。
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2.发明申请INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 AND METHODS OF THEIR USE 有权SODIUM GLUCOSE CO-TRANSPORTER 2的抑制剂及其使用方法公开(公告)号：US20080113922A1
公开(公告)日：2008-05-15
申请号：US11862690
申请日：2007-09-27
IPC分类号： A61K31/7008 , A61K31/7052 , A61K31/445 , C07H17/02 , C07D211/40
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
摘要翻译： 公开了包含它们的化合物和药物组合物，其可用于治疗诸如糖尿病和肥胖症的疾病和病症。
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公开(公告)号：US20100311673A1
公开(公告)日：2010-12-09
申请号：US12858666
申请日：2010-08-18
IPC分类号： A61K31/7028 , C07H15/04 , C07D309/10 , C07C251/16 , C07D211/46 , C07D335/02 , A61K31/351 , A61K31/138 , A61K31/451 , A61K31/382 , A61P3/10 , A61P9/12 , A61P3/00 , A61P3/04 , A61P9/00 , A61P9/10 , A61P5/50 , G01N33/50
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
摘要翻译： 公开了基于硫代烷基 - 四氢吡喃的化合物，包含它们的药物组合物及其用于治疗疾病和病症如糖尿病和肥胖症的方法。
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公开(公告)号：US20100076030A1
公开(公告)日：2010-03-25
申请号：US12628309
申请日：2009-12-01
申请人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
发明人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
IPC分类号： A61K31/417 , A61K31/4439 , A61P19/02
CPC分类号： C07D233/64 , A61K31/4164 , C07D401/12
摘要： Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了基于咪唑的化合物，包含它们的组合物及其用于治疗，预防和控制炎症和自身免疫性疾病和病症的方法。 特定的化合物具有式I：
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5.发明授权Imidazole-based compounds, compositions comprising them and methods of their use 有权基于咪唑的化合物，包含它们的组合物及其使用方法公开(公告)号：US07649098B2
公开(公告)日：2010-01-19
申请号：US11698253
申请日：2007-01-25
申请人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
发明人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
IPC分类号： C07D233/64 , A61K31/4164
CPC分类号： C07D233/64 , A61K31/4164 , C07D401/12
摘要： Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了基于咪唑的化合物，包含它们的组合物及其用于治疗，预防和控制炎症和自身免疫性疾病和病症的方法。 特定的化合物具有式I：
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公开(公告)号：US08952023B1
公开(公告)日：2015-02-10
申请号：US13861858
申请日：2013-04-12
申请人： Xinyuan Wu , Spencer David Kimball
发明人： Xinyuan Wu , Spencer David Kimball
IPC分类号： A61K31/519 , C07D239/70 , C07D471/04
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
摘要翻译： 本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。
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7.发明申请SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE 有权SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS及其使用方法公开(公告)号：US20140135277A1
公开(公告)日：2014-05-15
申请号：US13925981
申请日：2013-06-25
IPC分类号： C07H15/14
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
摘要翻译： 公开了基于硫代烷基 - 四氢吡喃的化合物，包含它们的药物组合物及其用于治疗疾病和病症如糖尿病和肥胖症的方法。
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公开(公告)号：US08530487B1
公开(公告)日：2013-09-10
申请号：US12696618
申请日：2010-01-29
申请人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
发明人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
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![Substituted pyrrolo[2,3-d]pyrimidines as LIM kinase 2 inhibitors](/abs-image/US/2013/08/13/US08507672B2/abs.jpg.150x150.jpg)
9.发明授权公开(公告)号：US08507672B2
公开(公告)日：2013-08-13
申请号：US12188515
申请日：2008-08-08
申请人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Dennis S. Rice , Michael Victor Voronkov , Yulian Zhang
发明人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Dennis S. Rice , Michael Victor Voronkov , Yulian Zhang
IPC分类号： C07D487/04 , A61K31/519 , A61K31/4985 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Substituted pyrrolo[2,3-d]pyrimidine-based compounds useful as inhibitors of LIM kinase 2 are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds and methods of their use to treat, manage and prevent inflammatory diseases and disorders, cancer, and diseases and disorders of the eye.
摘要翻译： 公开了可用作LIM激酶2的抑制剂的取代的吡咯并[2,3-d]嘧啶类化合物。 还公开了包含该化合物的药物组合物及其用于治疗，治疗和预防炎性疾病和病症，癌症以及眼睛疾病和病症的方法。
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公开(公告)号：US08093267B2
公开(公告)日：2012-01-10
申请号：US12628309
申请日：2009-12-01
申请人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
发明人： David J. Augeri , Jeffrey Bagdanoff , Lakmal W. Boteju , Kenneth G. Carson , Theodore C. Jessop , Spencer David Kimball
IPC分类号： A61K31/4164 , C07D233/64
CPC分类号： C07D233/64 , A61K31/4164 , C07D401/12
摘要： Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了基于咪唑的化合物，包含它们的组合物及其用于治疗，预防和控制炎症和自身免疫性疾病和病症的方法。 特定的化合物具有式I：
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