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1.发明申请GESTATIONAL AGE DEPENDENT PROTEOMIC CHANGES OF HUMAN MATERNAL SERUM FOR MONITORING MATERNAL AND FETAL HEALTH 审中-公开人体年龄依赖性人体血清监测用于监测和保健的保健措施公开(公告)号：US20100017143A1
公开(公告)日：2010-01-21
申请号：US12363651
申请日：2009-01-30
CPC分类号： G01N33/689 , G01N33/6803
摘要： The present invention concerns a global maternal serum proteome map and its changes during healthy gestation. Accordingly, the present invention provides an important tool for plasma-based maternal-fetal diagnostics.
摘要翻译： 本发明涉及全球母体血清蛋白质组图及其在健康妊娠期间的变化。 因此，本发明提供了基于血浆的母胎诊断的重要工具。
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2.发明授权Methods for detecting pre-diabetes and diabetes using differential protein glycosylation 有权使用差异蛋白糖基化检测糖尿病前期和糖尿病的方法公开(公告)号：US08168396B2
公开(公告)日：2012-05-01
申请号：US12777955
申请日：2010-05-11
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译： 本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。 还提供了用于鉴定糖尿病受试者的方法。 还公开了用于鉴定患有糖尿病并发症的个体的方法。 所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。 在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。
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3.发明申请METHODS FOR DETECTING PRE-DIABETES AND DIABETES USING DIFFERENTIAL PROTEIN GLYCOSYLATION 有权使用差异蛋白质糖蛋白检测预先糖尿病和糖尿病的方法公开(公告)号：US20120208218A1
公开(公告)日：2012-08-16
申请号：US13457243
申请日：2012-04-26
IPC分类号： G01N33/566
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译： 本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。 还提供了用于鉴定糖尿病受试者的方法。 还公开了用于鉴定患有糖尿病并发症的个体的方法。 所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。 在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。
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公开(公告)号：US08530175B2
公开(公告)日：2013-09-10
申请号：US13457225
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
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5.发明授权Methods for detecting pre-diabetes and diabetes using differential protein glycosylation 有权使用差异蛋白糖基化检测糖尿病前期和糖尿病的方法公开(公告)号：US08497076B2
公开(公告)日：2013-07-30
申请号：US13457200
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译： 本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。 还提供了用于鉴定糖尿病受试者的方法。 还公开了用于鉴定患有糖尿病并发症的个体的方法。 所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。 在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。
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公开(公告)号：US08476008B2
公开(公告)日：2013-07-02
申请号：US13055605
申请日：2009-07-23
IPC分类号： C12Q1/00
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Non-invasive methods are provided herein for the diagnosis of pre-diabetes and diabetes using biomarkers identified in a biological fluid, such as saliva. These biomarkers can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.
摘要翻译： 本文提供了非侵入性方法，用于使用生物流体（例如唾液）中鉴定的生物标志物来诊断糖尿病前和糖尿病。 可以使用蛋白质组学方法鉴定这些生物标志物，包括但不限于基于抗体的方法，例如酶联免疫吸附测定（ELISA），放射免疫测定（RIA）或侧流免疫测定。
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公开(公告)号：US20120208217A1
公开(公告)日：2012-08-16
申请号：US13457200
申请日：2012-04-26
IPC分类号： G01N33/566
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
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公开(公告)号：US5439884A
公开(公告)日：1995-08-08
申请号：US919731
申请日：1992-07-27
IPC分类号： A61K38/00 , C07K7/08 , C07K14/575 , A61K38/10 , A61K38/17
CPC分类号： C07K14/57572 , C07K7/086 , A61K38/00
摘要： A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective amount of bombesin or its analog capable of stimulating or inhibiting the acrosome reaction.
摘要翻译： 一种促进或阻断受精的方法，该方法包括在精子获能时或在卵子受精时将精子与有效量的铃蟾肽或其能够刺激或抑制顶体反应的类似物接触的步骤。
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公开(公告)号：US08497077B2
公开(公告)日：2013-07-30
申请号：US13457243
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
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10.发明申请公开(公告)号：US20120214179A1
公开(公告)日：2012-08-23
申请号：US13457225
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
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