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公开(公告)号：US5656749A
公开(公告)日：1997-08-12
申请号：US279590
申请日：1994-07-22
IPC分类号： C07K14/705 , C12N15/12
CPC分类号： C07K14/70571
摘要： Pure nucleic acids encoding novel receptors for bombesin-like peptides, the novel receptors themselves, and their antibodies. Also disclosed is a method of screening for a compound capable of interacting with any of these novel receptors.
摘要翻译： 编码铃蟾肽样肽的新受体的纯核酸，新受体本身及其抗体。 还公开了筛选能够与任何这些新受体相互作用的化合物的方法。
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公开(公告)号：US5439884A
公开(公告)日：1995-08-08
申请号：US919731
申请日：1992-07-27
IPC分类号： A61K38/00 , C07K7/08 , C07K14/575 , A61K38/10 , A61K38/17
CPC分类号： C07K14/57572 , C07K7/086 , A61K38/00
摘要： A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective amount of bombesin or its analog capable of stimulating or inhibiting the acrosome reaction.
摘要翻译： 一种促进或阻断受精的方法，该方法包括在精子获能时或在卵子受精时将精子与有效量的铃蟾肽或其能够刺激或抑制顶体反应的类似物接触的步骤。
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3.发明授权
公开(公告)号：US5436137A
公开(公告)日：1995-07-25
申请号：US39778
申请日：1993-03-23
IPC分类号： A61K38/00 , A61P13/02 , A61P15/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C12N15/09 , C12P21/06 , A61K7/46 , C07H19/00 , C12N9/48
CPC分类号： C07K14/57572 , C07K7/086 , A61K38/00
摘要： A pure DNA encoding a peptide which is capable of promoting acrosome reaction and the encoded peptide. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, a method of promoting fertilization using such a peptide, and a method of preparing such a peptide by recombinant technology.
摘要翻译： 编码能够促进顶体反应的肽的纯DNA和编码的肽。 还公开了含有这种DNA的载体和细胞，包含这种肽的药物组合物，使用这种肽促进受精的方法，以及通过重组技术制备这种肽的方法。
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公开(公告)号：US5410018A
公开(公告)日：1995-04-25
申请号：US203196
申请日：1994-02-25
IPC分类号： C12N15/09 , A61K38/00 , A61P43/00 , C07H21/04 , C07K7/08 , C07K14/575 , C12N5/10 , C12P21/02 , A61K37/00 , A01N43/40 , A61K31/445
CPC分类号： C07K14/57572 , C07K7/086 , A61K38/00
摘要： A pure DNA encoding a peptide which encodes a novel bombesin-related peptide, i.e., H-pGlu-Gln-Ser-Leu-Gly-Asn-Gin-Trp-Ala-Arg-Gly-His-Phe-Met-NH.sub.2 or Gly-Asn-Gln-Trp-Ala-Arg-Gly-His-Phe-Met-NH.sub.2. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, and a method of preparing such a peptide by recombinant technology.
摘要翻译： 编码编码新的铃蟾肽相关肽即H-pGlu-Gln-Ser-Leu-Gly-Asn-Gin-Trp-Ala-Arg-Gly-His-Phe-Met-NH2或Gly的肽的纯DNA -Asn-Gln-Trp-Ala-Arg-Gly-His-Phe-Met-NH2。 还公开了含有这种DNA的载体和细胞，包含这种肽的药物组合物，以及通过重组技术制备这种肽的方法。
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5.发明申请M3 MUSCARINIC RECEPTOR ANTAGONISTS FOR TREATMENT OF M3 MUSCARINIC RECEPTOR-EXPRESSING TUMORS 审中-公开M3 MUSCARINIC受体表达肿瘤治疗M3 MUSCARINIC受体拮抗剂公开(公告)号：US20090062326A1
公开(公告)日：2009-03-05
申请号：US12281976
申请日：2007-03-16
IPC分类号： A61K31/46 , A61K31/40 , A61K31/445 , A61K31/045 , A61P35/00 , A61K31/4725 , A61K31/216
CPC分类号： A61K31/4025 , A61K9/0095 , A61K31/13 , A61K31/216 , A61K31/4453 , A61K31/452 , A61K31/4525 , A61K31/46 , A61K31/4709 , A61K45/06 , A61K2300/00
摘要： The present disclosure provides methods of treating a tumor using M3 muscarininc receptor antagonists, such as darifenacin. In some examples, the tumor expresses M3 muscarinic receptors, such as tumors associated with smoking. Also provided are compositions that can be used to practice such methods.
摘要翻译： 本公开提供了使用M3毒蕈碱蛋白酶受体拮抗剂如达赖芬那定治疗肿瘤的方法。 在一些实例中，肿瘤表达M3毒蕈碱受体，例如与吸烟相关的肿瘤。 还提供了可用于实施这些方法的组合物。
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6.发明授权Screening assays using nucleic acids encoding receptors for bombesin-like peptides 失效使用编码铃蟾肽样肽的受体的核酸进行筛选试验
公开(公告)号：US5814463A
公开(公告)日：1998-09-29
申请号：US910092
申请日：1997-08-12
IPC分类号： C07K14/705 , C12N15/12 , C12Q1/00
CPC分类号： C07K14/70571
摘要： Pure nucleic acids encoding novel receptors for bombesin-like peptides, the novel receptors themselves, and their antibodies. Also disclosed is a method of screening for a compound capable of interacting with any of these novel receptors.
摘要翻译： 编码铃蟾肽样肽的新受体的纯核酸，新受体本身及其抗体。 还公开了筛选能够与任何这些新受体相互作用的化合物的方法。
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