公开(公告)号：US20130310458A1

公开(公告)日：2013-11-21

申请号：US13695769

申请日：2011-05-03

Applicant: Lothar Eggeling ,  Michael Bott ,  Stephan Binder ,  Julia Frunzke ,  Nurije Mustafi

Inventor： Lothar Eggeling ,  Michael Bott ,  Stephan Binder ,  Julia Frunzke ,  Nurije Mustafi

IPC: C12P13/08 ,  C12N15/67

CPC classification number: C12Q1/6897 ,  C12N15/115 ,  C12N15/63 ,  C12N15/67 ,  C12N15/70 ,  C12N15/77 ,  C12N2310/16 ,  C12N2310/3519 ,  C12P13/08 ,  C12Q1/689 ,  C12Q2600/156

Abstract: The present invention relates to a cell which is genetically modified with respect to its wild type and which comprises a gene sequence coding for an autofluorescent protein, wherein the expression of the autofluorescent protein depends on the intracellular concentration of a particular metabolite.The present invention also relates to a method for the identification of a cell having an increased intracellular concentration of a particular metabolite, a method for the production of a cell which is genetically modified with respect to its wild type with optimized production of a particular metabolite, a cell obtained by this method, a method for the production of metabolites and a method for the preparation of a mixture.

Abstract translation: 本发明涉及对其野生型进行遗传修饰的细胞，其包含编码自体荧光蛋白的基因序列，其中所述自体荧光蛋白的表达取决于特定代谢物的细胞内浓度。 本发明还涉及一种用于鉴定具有增加的特定代谢物的细胞内浓度的细胞的方法，用于生产相对于其野生型经遗传修饰的细胞的方法，优化了特定代谢物的产生， 通过该方法获得的细胞，生产代谢物的方法和制备混合物的方法。

公开(公告)号：US20140006208A1

公开(公告)日：2014-01-02

申请号：US13535618

申请日：2012-06-28

Applicant: Robert B. Fuhge ,  Frank Kohler ,  Joachim Pfeifer ,  Thomas Witzel ,  Katja Zoch ,  Michael Oemler ,  Velislav Ivanov ,  Stephan Binder

Inventor： Robert B. Fuhge ,  Frank Kohler ,  Joachim Pfeifer ,  Thomas Witzel ,  Katja Zoch ,  Michael Oemler ,  Velislav Ivanov ,  Stephan Binder

IPC: G06Q30/00

CPC classification number: G06Q30/06 ,  G06Q10/0875 ,  G06Q10/10 ,  G06Q30/04

Abstract: A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to a product catalogue and a product tax classification assignment business object.

Abstract translation: 用于反映在给定业务事务期间使用的数据的业务对象模型被用于生成接口。 该业务对象模型通过提供一致的接口来促进商业交易，该接口适合于在业务交易期间跨业务，跨企业以及业务中的不同部门使用。 在某些操作中，软件创建，更新或以其他方式处理与产品目录和产品税分类分配业务对象相关的信息。