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公开(公告)号：US20050095619A1
公开(公告)日：2005-05-05
申请号：US10915927
申请日：2004-08-11
Applicant: S. Davis , Stephane Jenne , Anke Krebber , Lisa Newman
Inventor： S. Davis , Stephane Jenne , Anke Krebber , Lisa Newman
CPC classification number: C12N9/0006
Abstract: The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase polypeptide. In addition, the present invention is directed to a polynucleotide that encodes for the GDH polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the GDH polypeptides, and to a method for producing the GDH polypeptides of the present invention.
Abstract translation: 本发明涉及相对于骨架野生型葡萄糖脱氢酶多肽具有增强的GDH活性和/或热稳定性的葡萄糖脱氢酶（GDH）多肽。 此外，本发明涉及编码本发明的GDH多肽的多核苷酸，包含多核苷酸的核酸序列，包含与启动子有效连接的多核苷酸的表达载体，转化为表达GDH的宿主细胞 多肽，以及本发明的GDH多肽的制备方法。
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公开(公告)号：US20080015116A1
公开(公告)日：2008-01-17
申请号：US11677505
申请日：2007-02-21
Applicant: Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
Inventor： Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
IPC: C40B60/04
CPC classification number: C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
Abstract translation: 提供了用于多样化生成和筛选的集成系统和方法。 该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。
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公开(公告)号：US20060195947A1
公开(公告)日：2006-08-31
申请号：US10916311
申请日：2004-08-11
Applicant: S. Davis , Gjalt Huisman , Stephane Jenne , Anke Krebber , Lisa Newman
Inventor： S. Davis , Gjalt Huisman , Stephane Jenne , Anke Krebber , Lisa Newman
CPC classification number: C12N9/0006
Abstract: The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
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公开(公告)号：US07462469B2
公开(公告)日：2008-12-09
申请号：US10154936
申请日：2002-05-23
Applicant: Steven H. Bass , S. Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claes Gustafsson , Brian Carr , Stephane Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
Inventor： Steven H. Bass , S. Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claes Gustafsson , Brian Carr , Stephane Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
CPC classification number: C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
Abstract translation: 提供了用于多样化生成和筛选的集成系统和方法。 该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。
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