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1.发明申请公开(公告)号：US20120252681A1
公开(公告)日：2012-10-04
申请号：US13310332
申请日：2011-12-02
Applicant: Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
Inventor： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
IPC: C40B10/00
CPC classification number: C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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公开(公告)号：US07853410B2
公开(公告)日：2010-12-14
申请号：US11975638
申请日：2007-10-18
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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公开(公告)号：US20100248312A1
公开(公告)日：2010-09-30
申请号：US11581946
申请日：2006-10-16
Applicant: Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
Inventor： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
Abstract translation: 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。
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4.发明申请Methods for making character strings, polynucleotides and polypeptides having desired characteristics 有权制备具有所需特征的字符串，多核苷酸和多肽的方法公开(公告)号：US20080318795A1
公开(公告)日：2008-12-25
申请号：US11982405
申请日：2007-10-31
Applicant: Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
IPC: C40B10/00
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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5.发明授权Methods for making character strings, polynucleotides and polypeptides having desired characteristics 有权制备具有所需特征的字符串，多核苷酸和多肽的方法公开(公告)号：US06917882B2
公开(公告)日：2005-07-12
申请号：US09494282
申请日：2000-01-18
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
IPC: A61K39/00 , C07K14/16 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/10 , C12N15/11 , G06F19/00 , G01N33/48 , C07H21/02 , C07H21/04 , C12Q1/00 , C12Q1/48 , C12Q1/68
CPC classification number: C12N15/1031 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1027 , C12N15/11 , C12N2740/16122
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 提供了“计算机”核酸重组方法，利用遗传算子和利用计算机混洗方法制作的图书馆的相关综合系统。
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Patent Agency Ranking
公开(公告)号：US06287862B1
公开(公告)日：2001-09-11
申请号：US09626410
申请日：2000-07-26
Applicant: Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus M. Krebber , Steven H. Bass
Inventor： Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus M. Krebber , Steven H. Bass
IPC: C12N1500
CPC classification number: C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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公开(公告)号：US5813929A
公开(公告)日：1998-09-29
申请号：US767215
申请日：1996-12-16
Applicant: Matthew Tobin
Inventor： Matthew Tobin
CPC classification number: A63B63/083 , A63B2210/50 , A63B71/023
Abstract: A new Portable Hoop and Backboard Assembly that is easily installed and disassembled. The inventive device includes a rim, a light weight backboard that is equipped with bendable protrusions to stabilize the assembly, straps for attaching the backboard, and a rim that is collapsible.
Abstract translation: 便于安装和拆卸的新型便携式环形和背板组件。 本发明的装置包括边缘，轻质背板，其配备有可弯曲突起以稳定组件，用于附接背板的带子和可折叠的边缘。
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8.发明申请METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDURE 审中-公开用于鉴定体外重组程序中使用寡核苷酸的方法公开(公告)号：US20110257892A1
公开(公告)日：2011-10-20
申请号：US13095797
申请日：2011-04-27
Applicant: Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
IPC: G06F19/00
CPC classification number: G16B20/00 , B01J2219/007 , G16B10/00 , G16B15/00 , G16B30/00 , G16B35/00 , G16B40/00 , G16C20/60
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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公开(公告)号：US07421347B2
公开(公告)日：2008-09-02
申请号：US11075231
申请日：2005-03-07
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
CPC classification number: C12N15/1031 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1027 , C12N15/11 , C12N2740/16122
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 提供了“计算机”核酸重组方法，利用遗传算子和利用计算机混洗方法制作的图书馆的相关综合系统。
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10.发明授权公开(公告)号：US07058515B1
公开(公告)日：2006-06-06
申请号：US09539486
申请日：2000-03-30
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: C12N15/11 , B01J2219/00689 , C12N15/1031
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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