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1.发明授权公开(公告)号：US08496943B2
公开(公告)日：2013-07-30
申请号：US11183477
申请日：2005-07-18
申请人： Pamela J. Fereira , Michael A. Desjardin , Catherine M. Rohloff , Stephen A. Berry , Ekaterina S. Zlatkova-Karaslavova
发明人： Pamela J. Fereira , Michael A. Desjardin , Catherine M. Rohloff , Stephen A. Berry , Ekaterina S. Zlatkova-Karaslavova
IPC分类号： A61K9/00
CPC分类号： A61K47/32 , A61K9/0004
摘要： The present invention is related to materials and methods for forming polymeric delivery vehicles that reduces risk of oxidative degradation of a carried drug and the resulting compositions.
摘要翻译： 本发明涉及用于形成聚合物递送载体的材料和方法，其降低被携带药物和所得组合物的氧化降解的风险。
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2.发明授权Stable non-aqueous single phase viscous vehicles and formulations utlizing such vehicles 有权稳定的非水单相粘性车辆和使用这种车辆的配方公开(公告)号：US08173150B2
公开(公告)日：2012-05-08
申请号：US13043288
申请日：2011-03-08
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
摘要翻译： 本发明涉及稳定的非水性单相粘性载体和利用这种载体的制剂。 制剂包含均匀悬浮在载体中的至少一种有益剂。 该制剂能够在从寒冷到体温的温度下长时间储存。 制剂能够以约1至1×10-7倒数第二次的出口剪切速率从药物递送系统均匀递送。
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3.发明授权Stable non- aqueous single phase viscous vehicles and formulations utilizing such vehicles 有权稳定的非水性单相粘性载体和利用这种载体的制剂公开(公告)号：US08048438B2
公开(公告)日：2011-11-01
申请号：US12077117
申请日：2008-03-17
IPC分类号： A61F13/00
CPC分类号： A61K38/27 , A61K9/0004 , A61K9/0024 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/44 , Y10S514/937 , Y10T29/49826
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
摘要翻译： 本发明涉及稳定的非水性单相粘性载体和利用这种载体的制剂。 制剂包含均匀悬浮在载体中的至少一种有益剂。 该制剂能够在从寒冷到体温的温度下长时间储存。 制剂能够以约1至1×10-7倒数第二次的出口剪切速率从药物递送系统均匀递送。
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4.发明授权Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles 有权稳定的非水性单相粘性载体和使用这种载体的制剂公开(公告)号：US08268341B2
公开(公告)日：2012-09-18
申请号：US13454063
申请日：2012-04-23
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
摘要翻译： 本发明涉及稳定的非水性单相粘性载体和利用这种载体的制剂。 制剂包含均匀悬浮在载体中的至少一种有益剂。 该制剂能够在从寒冷到体温的温度下长时间储存。 制剂能够以约1至1×10-7倒数第二次的出口剪切速率从药物递送系统均匀递送。
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5.发明申请STABLE NON-AQUEOUS SINGLE PHASE VISCOUS VEHICLES AND FORMULATIONS UTLIZING SUCH VEHICLES 有权稳定的非水性单相VISCOUS车辆和配套此类车辆的配方公开(公告)号：US20110160708A1
公开(公告)日：2011-06-30
申请号：US13043288
申请日：2011-03-08
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
摘要翻译： 本发明涉及稳定的非水性单相粘性载体和利用这种载体的制剂。 制剂包含均匀悬浮在载体中的至少一种有益剂。 该制剂能够在从寒冷到体温的温度下长时间储存。 制剂能够以约1至1×10-7倒数第二次的出口剪切速率从药物递送系统均匀递送。
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6.发明申请Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles 有权稳定的非水性单相粘性载体和使用这种载体的制剂公开(公告)号：US20080226689A1
公开(公告)日：2008-09-18
申请号：US12075435
申请日：2008-03-11
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
摘要翻译： 本发明涉及稳定的非水性单相粘性载体和利用这种载体的制剂。 制剂包含均匀悬浮在载体中的至少一种有益剂。 该制剂能够在从寒冷到体温的温度下长时间储存。 制剂能够以约1至1×10 -7 -7倒数第二次的出口剪切速率从药物递送系统均匀递送。
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公开(公告)号：US07074423B2
公开(公告)日：2006-07-11
申请号：US10463300
申请日：2003-06-17
IPC分类号： A61F2/00
CPC分类号： A61K9/4808 , A61K9/0004 , A61K9/0024
摘要： The present invention is directed to an osmotic engine useful in an osmotic delivery system for delivery of a beneficial agent in a controlled manner over a preselected administration period. By including a flowable engine comprising at least one osmotic agent and at least one fluid vehicle, the resulting osmotic engine reaches a zero order push power or push rate quickly and provides steady delivery of the beneficial agent.
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8.发明授权公开(公告)号：US08372424B2
公开(公告)日：2013-02-12
申请号：US13596971
申请日：2012-08-28
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
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9.发明申请公开(公告)号：US20120322720A1
公开(公告)日：2012-12-20
申请号：US13596971
申请日：2012-08-28
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
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10.发明授权Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles 有权稳定的非水性单相粘性载体和使用这种载体的制剂公开(公告)号：US07919109B2
公开(公告)日：2011-04-05
申请号：US12075435
申请日：2008-03-11
摘要： This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10−7 reciprocal second.
摘要翻译： 本发明涉及稳定的非水性单相粘性载体和利用这种载体的制剂。 制剂包含均匀悬浮在载体中的至少一种有益剂。 该制剂能够在从寒冷到体温的温度下长时间储存。 制剂能够以约1至1×10-7倒数第二次的出口剪切速率从药物递送系统均匀递送。
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