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1.
公开(公告)号:US20090131395A1
公开(公告)日:2009-05-21
申请号:US11913461
申请日:2006-05-05
申请人: Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley , Timothy C. Barden , JingJing Yang , Daniel P. Zimmer
发明人: Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley , Timothy C. Barden , JingJing Yang , Daniel P. Zimmer
IPC分类号: A61K31/397 , C07D205/08 , A61P9/10
CPC分类号: C07D205/08 , C07D405/10 , C07F9/568 , C07F9/65586 , C07H7/04 , C07H15/203
摘要: The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula I: Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.
摘要翻译: 本发明涉及可用于治疗高胆固醇血症和其他疾病的4-联苯-1-苯基氮杂环丁烷-2-酮的化学属。 该化合物具有通式I:还公开了用于治疗胆固醇和脂质相关疾病的药物组合物和方法。
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2.Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids 审中-公开
标题翻译: 制备4-(联苯基)氮杂环丁烷-2-酮膦酸的方法公开(公告)号:US20090099355A1
公开(公告)日:2009-04-16
申请号:US11915241
申请日:2006-05-25
申请人: Stephen Antonelli , Timothy C. Barden , Peter Lee , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
发明人: Stephen Antonelli , Timothy C. Barden , Peter Lee , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
IPC分类号: C07D205/08 , C07D263/22 , C07C211/28 , C07F9/38
CPC分类号: C07C251/24 , C07D205/08 , C07D263/26 , C07D309/30 , C07D309/38 , C07F7/1892 , C07F9/568
摘要: The present invention relates to processes for the production of 4-(biphenylyl)azetidin-2-one phosphonic acid derivatives of formula
摘要翻译: 本发明涉及制备式(I)的4-(联苯基)吖丁啶-2-酮膦酸衍生物的方法
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公开(公告)号:US07320972B2
公开(公告)日:2008-01-22
申请号:US10986570
申请日:2004-11-10
申请人: Eduardo Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
发明人: Eduardo Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
IPC分类号: C07D205/08 , A61K31/397 , A61K31/7052 , A61P3/06 , A61P9/10
CPC分类号: C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要: 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译: 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 所述化合物具有通式,其中代表芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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公开(公告)号:US20050209165A1
公开(公告)日:2005-09-22
申请号:US10986570
申请日:2004-11-10
申请人: Eduardo Martinez , John Talley , Stephen Antonelli , Timothy Barden , Regina Lundrigan-Soucy , Wayne Schairer , Jing-Jing Yang , Daniel Zimmer
发明人: Eduardo Martinez , John Talley , Stephen Antonelli , Timothy Barden , Regina Lundrigan-Soucy , Wayne Schairer , Jing-Jing Yang , Daniel Zimmer
IPC分类号: A61K31/337 , A61K31/397 , A61K31/675 , A61K31/69 , A61K31/7052 , A61K45/06 , C07D205/08 , C07D405/10
CPC分类号: C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要: 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译: 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 所述化合物具有通式,其中代表芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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公开(公告)号:US20080167255A1
公开(公告)日:2008-07-10
申请号:US11954170
申请日:2007-12-11
申请人: Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
发明人: Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
IPC分类号: A61K31/7052 , C07D205/04 , A61K31/397 , A61K31/69 , A61P9/00 , A61K31/66 , C07H15/00
CPC分类号: C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要: 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译: 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 该化合物具有以下通式:其中表示芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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6.
公开(公告)号:US20080287663A1
公开(公告)日:2008-11-20
申请号:US11913587
申请日:2006-05-08
申请人: Peter Lee , Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
发明人: Peter Lee , Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley
IPC分类号: C07H7/04
CPC分类号: C07C251/24 , C07C229/34 , C07D205/08 , C07D263/26 , C07D405/10 , C07F5/025 , C07F7/1804 , C07F7/1892
摘要: The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula
摘要翻译: 本发明涉及制备式的4-联苯基氮杂环丁烷-2-酮衍生物的方法
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