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公开(公告)号：US20080167255A1
公开(公告)日：2008-07-10
申请号：US11954170
申请日：2007-12-11
申请人： Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
发明人： Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
IPC分类号： A61K31/7052 , C07D205/04 , A61K31/397 , A61K31/69 , A61P9/00 , A61K31/66 , C07H15/00
CPC分类号： C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要： 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译： 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 该化合物具有以下通式：其中
表示芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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公开(公告)号：US07320972B2
公开(公告)日：2008-01-22
申请号：US10986570
申请日：2004-11-10
申请人： Eduardo Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
发明人： Eduardo Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
IPC分类号： C07D205/08 , A61K31/397 , A61K31/7052 , A61P3/06 , A61P9/10
CPC分类号： C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要： 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译： 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 所述化合物具有通式，其中代表芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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公开(公告)号：US20090131395A1
公开(公告)日：2009-05-21
申请号：US11913461
申请日：2006-05-05
申请人： Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley , Timothy C. Barden , JingJing Yang , Daniel P. Zimmer
发明人： Stephen Antonelli , Regina Lundrigan , Eduardo J. Martinez , Wayne C. Schairer , John J. Talley , Timothy C. Barden , JingJing Yang , Daniel P. Zimmer
IPC分类号： A61K31/397 , C07D205/08 , A61P9/10
CPC分类号： C07D205/08 , C07D405/10 , C07F9/568 , C07F9/65586 , C07H7/04 , C07H15/203
摘要： The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula I: Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.
摘要翻译： 本发明涉及可用于治疗高胆固醇血症和其他疾病的4-联苯-1-苯基氮杂环丁烷-2-酮的化学属。 该化合物具有通式I：还公开了用于治疗胆固醇和脂质相关疾病的药物组合物和方法。
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公开(公告)号：US20130130995A1
公开(公告)日：2013-05-23
申请号：US13514158
申请日：2010-12-07
CPC分类号： C07K7/08 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K45/06
摘要： Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein.
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公开(公告)号：US08735360B2
公开(公告)日：2014-05-27
申请号：US13514158
申请日：2010-12-07
CPC分类号： C07K7/08 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K45/06
摘要： Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein.
摘要翻译： 本文描述了用于治疗上消化道疾病和病症（例如，消化不良，胃轻瘫，术后胃肠梗阻，功能性食管障碍，功能性胃十二指肠疾病，胃食管反流病（GERD）或十二指肠癌）的肽，组合物和相关方法 或胃溃疡）以及本文所述的其它病症和障碍。
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公开(公告)号：US20140342996A1
公开(公告)日：2014-11-20
申请号：US14124282
申请日：2012-06-08
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.
摘要翻译： 本发明提供了治疗较低胃肠道疾病（包括肠易激综合征和便秘）的药物组合物和方法。
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7.发明申请SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS 审中-公开用于治疗脂肪相关疾病的可溶性葡萄糖环化酶（SGC）调节剂公开(公告)号：US20100144864A1
公开(公告)日：2010-06-10
申请号：US12594744
申请日：2008-04-03
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
CPC分类号： A61K31/34 , A61K31/04 , A61K31/165 , A61K31/192 , A61K31/21 , A61K31/40 , A61K31/407 , A61K31/5377 , A61K31/541
摘要： Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more sGC modulators alone or in combination with one or more lipid altering agents and/or PDE inhibitors.
摘要翻译： 本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。 所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含单独一种或多种sGC调节剂或与一种或多种脂质改变剂和/或PDE抑制剂组合。
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公开(公告)号：US20090005321A1
公开(公告)日：2009-01-01
申请号：US11815775
申请日：2006-02-09
申请人： Daniel P. Zimmer , John Jeffrey Talley , Regina Lundrigan , Shannon Roberts , Eduardo J. Martinez
发明人： Daniel P. Zimmer , John Jeffrey Talley , Regina Lundrigan , Shannon Roberts , Eduardo J. Martinez
IPC分类号： A61K38/05 , A61K31/397 , C07D205/08 , C07H7/06 , A61K31/7052
CPC分类号： C07D405/12 , C07H7/04
摘要： Various azetidinone derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.
摘要翻译： 描述了各种氮杂环丁酮衍生物，以及含有这些化合物的药物组合物和使用这些化合物治疗疾病的方法。 还描述了其它实施例。
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公开(公告)号：US20140348942A1
公开(公告)日：2014-11-27
申请号：US14124286
申请日：2012-06-08
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.
摘要翻译： 本发明提供了治疗下消化道疾病的药物组合物和方法，包括炎症性肠病（IBD），憩室炎，结肠癌，炎症性疾病，肥胖，充血性心力衰竭，良性前列腺增生（BPH），疼痛，盐滞留或流体 保留。
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公开(公告)号：US20120088902A1
公开(公告)日：2012-04-12
申请号：US12306788
申请日：2007-06-27
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
CPC分类号： C07K14/4705 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.
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