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公开(公告)号：US20080167255A1
公开(公告)日：2008-07-10
申请号：US11954170
申请日：2007-12-11
申请人： Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
发明人： Eduardo J. Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
IPC分类号： A61K31/7052 , C07D205/04 , A61K31/397 , A61K31/69 , A61P9/00 , A61K31/66 , C07H15/00
CPC分类号： C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要： 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译： 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 该化合物具有以下通式：其中
表示芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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公开(公告)号：US07320972B2
公开(公告)日：2008-01-22
申请号：US10986570
申请日：2004-11-10
申请人： Eduardo Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
发明人： Eduardo Martinez , John J. Talley , Stephen Antonelli , Timothy C. Barden , Regina Lundrigan-Soucy , Wayne C. Schairer , Jing-Jing Yang , Daniel P. Zimmer , Brian Cali , Mark G. Currie , Peter S. Yorgey
IPC分类号： C07D205/08 , A61K31/397 , A61K31/7052 , A61P3/06 , A61P9/10
CPC分类号： C07D205/08 , A61K31/337 , A61K31/397 , A61K45/06 , C07D263/20 , C07D401/04 , C07D405/10 , C07D409/04 , C07D453/02 , C07F7/1804 , C07F9/568 , C07H7/04 , C07H15/203 , A61K2300/00
摘要： 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
摘要翻译： 公开了可用于治疗高胆固醇血症的4-二苄基-1-苯基氮杂环丁-2-酮。 所述化合物具有通式，其中代表芳基或杂芳基残基; Ar表示芳基残基; U是2至6个原子链; R代表取代基。
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公开(公告)号：US20130130995A1
公开(公告)日：2013-05-23
申请号：US13514158
申请日：2010-12-07
CPC分类号： C07K7/08 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K45/06
摘要： Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein.
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公开(公告)号：US08735360B2
公开(公告)日：2014-05-27
申请号：US13514158
申请日：2010-12-07
CPC分类号： C07K7/08 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K45/06
摘要： Described herein are peptides, compositions, and related methods for treating upper gastrointestinal disorders and conditions (e.g., dyspepsia, gastroparesis, post-operative gastric ileus, a functional esophageal disorder, a functional gastroduodenal disorder, gastroesophageal reflux disease (GERD), or a duodenal or stomach ulcer) as well as other conditions and disorders that are described herein.
摘要翻译： 本文描述了用于治疗上消化道疾病和病症（例如，消化不良，胃轻瘫，术后胃肠梗阻，功能性食管障碍，功能性胃十二指肠疾病，胃食管反流病（GERD）或十二指肠癌）的肽，组合物和相关方法 或胃溃疡）以及本文所述的其它病症和障碍。
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公开(公告)号：US07205329B2
公开(公告)日：2007-04-17
申请号：US11183626
申请日：2005-07-18
申请人： Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
发明人： Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
IPC分类号： A61K31/405 , C07D209/12
CPC分类号： C07D409/06 , C07D209/42
摘要： Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
摘要翻译： 描述了CRTH2受体的调节剂及其在治疗各种疾病（包括哮喘）中的用途。
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公开(公告)号：US09617305B2
公开(公告)日：2017-04-11
申请号：US14124286
申请日：2012-06-08
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.
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公开(公告)号：US20130085107A1
公开(公告)日：2013-04-04
申请号：US13508843
申请日：2010-11-09
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , C07K7/08 , C07K14/4702
摘要： The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
摘要翻译： 本发明提供可用于治疗胃肠道疾病的肽。 本发明还提供治疗胃肠疾病的组合物和方法以及用于实现其的药物组合物。 在一些实施方案中，这些药物组合物包括口服剂型。
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8.发明申请公开(公告)号：US20120028897A1
公开(公告)日：2012-02-02
申请号：US13132262
申请日：2009-12-01
申请人： Mark G. Currie , Michael F. Goy , Marco M. Kessler , Nicholas G. Moss , Robert M. Solinga , Daniel P. Zimmer
发明人： Mark G. Currie , Michael F. Goy , Marco M. Kessler , Nicholas G. Moss , Robert M. Solinga , Daniel P. Zimmer
摘要： Methods of treating fluid retention disorders with the B isomers of guanylin family peptides are described herein. UgnB, when compared to the A isomer (UgnA), exhibits a conventional sigmoidal dose-response relationship in its natriuetic activity. Further, unlike UgnA, UgnB only weakly activates the GC-C receptor. Compositions comprising purified, or mixtures containing B isomers of guanylin family peptides are described herein are therefore useful for the treatment of fluid retention disorders.
摘要翻译： 本文描述了用鸟苷蛋白家族肽的B异构体治疗流体保留障碍的方法。 当与A异构体（UgnA）相比时，UgnB在其活性中表现出常规的S形剂量 - 反应关系。 此外，与UgnA不同，UgnB仅弱活化GC-C受体。 因此，本文描述了包含纯化的组合物或含有鸟苷蛋白家族肽的B异构体的混合物，因此可用于治疗流体保留障碍。
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公开(公告)号：US20110118184A1
公开(公告)日：2011-05-19
申请号：US12942887
申请日：2010-11-09
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , C07K7/08 , C07K14/4702
摘要： The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.
摘要翻译： 本发明提供可用于治疗胃肠道疾病的肽。 本发明还提供治疗胃肠疾病的组合物和方法以及用于实现其的药物组合物。 在一些实施方案中，这些药物组合物包括口服剂型。
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公开(公告)号：US20100010046A1
公开(公告)日：2010-01-14
申请号：US12304392
申请日：2007-06-08
申请人： Mark G. Currie , Daniel P. Zimmer
发明人： Mark G. Currie , Daniel P. Zimmer
IPC分类号： A61K31/407 , A61K31/4439 , A61P25/00
CPC分类号： A61K31/557 , A61K31/407 , A61K2300/00
摘要： Parenteral formulations comprising ketorolac, and a compound of formula II wherein R is hydrogen or lower alkyl. Such formulations are used for the treatment and prevention of pain.
摘要翻译： 包含酮咯酸和式II化合物的肠胃外制剂，其中R是氢或低级烷基。 这些制剂用于治疗和预防疼痛。
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