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公开(公告)号：US08877717B2
公开(公告)日：2014-11-04
申请号：US12531035
申请日：2008-03-11
IPC分类号： A61K31/70 , A61K31/7004 , A61K36/48
CPC分类号： A61K36/48 , A61K31/7004
摘要： Novel and useful compositions derived from rooibos for treating diabetes are provided. The present invention is particularly concerned with the treatment of Type 2 diabetes. The invention provides a new use for aspalathin and rutin and compositions containing them for use in the prevention and treatment of diabetes. The invention provides an anti-diabetic agent, an anti-diabetic composition containing the anti-diabetic agent, a foodstuff or beverage containing the anti-diabetic agent, a method for preventing or treating diabetes or impaired glucose tolerance, and a method of decreasing blood glucose level. The anti-diabetic agent may be an extract from rooibos (Aspalathus spp.), aspalathin as such or in combination with rutin.
摘要翻译： 提供了衍生自用于治疗糖尿病的rooibos的新型和有用的组合物。 本发明特别涉及2型糖尿病的治疗。 本发明为用于预防和治疗糖尿病的芦丁蛋白和芦丁以及含有它们的组合物提供了新的用途。 本发明提供一种抗糖尿病药，含有抗糖尿病药的抗糖尿病药物组合物，含有抗糖尿病药的食品或饮料，糖尿病的预防或治疗或葡萄糖耐量降低的方法，以及减少血液的方法 葡萄糖水平。 抗糖尿病药物可以是来自罗非鱼（Aspalathus spp。），天冬酰胺酶本身或与芦丁组合的提取物。
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公开(公告)号：US20130295660A1
公开(公告)日：2013-11-07
申请号：US13816997
申请日：2011-07-29
申请人： Stephen John Fey
发明人： Stephen John Fey
IPC分类号： C12M3/04
摘要： A bioreactor or culture vessel for incubation of one or more cell cultures, tissue biopsies, cell clusters, tissue-like structures, “prototissues” or similar samples. The bioreactor comprises an incubation chamber, a liquid reservoir and conduction means separated from each other by semipermeable membranes. Specifically, the invention provides a humidity chamber design which simplifies the construction of the bioreactor.
摘要翻译： 用于孵育一种或多种细胞培养物，组织活检，细胞簇，组织样结构，“原始组织”或类似样品的生物反应器或培养容器。 生物反应器包括孵育室，液体储存器和通过半透膜隔离的传导装置。 具体地说，本发明提供一种简化生物反应器结构的湿度室设计。
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公开(公告)号：US20100120136A1
公开(公告)日：2010-05-13
申请号：US12159154
申请日：2006-12-22
IPC分类号： C12M1/12
CPC分类号： G01N33/502 , C12M23/16 , C12M27/10 , C12M29/04 , C12N5/0671 , C12Q1/6809
摘要： The present invention provides a bioreacto 1r for incubation of cell cultures, tissue biopsies, cell clusters, tissue-like structures, ‘prototissues’ or similar samples. The bioreactor is generally adapted for rotation for use in microgravity conditions and equipped with an incubation cavity having a small internal fluid volume, generally less than 1 ml. To avoid problems associated with small volume incubation, the bioreactor may include a humidity chamber or other means of avoiding dehydration as well as substantially fluid-tight closures for access ports that avoid introduction of air bubbles to the incubation cavity. The small-volume bioreactor permits long term maintenance of tissue differentiation states in cultures. Also provided are methods of incubating cells or tissues using the bioreactor including methods of creating molecular profiles of biological effects of chemical compositions on differentiated cell or tissue samples maintained in long term culture.
摘要翻译： 本发明提供了用于孵育细胞培养物，组织活检，细胞簇，组织样结构，“原始组织”或类似样品的生物反应器1r。 生物反应器通常适于旋转用于微重力条件，并配备有通常小于1ml的小内部流体体积的孵育腔。 为了避免与小体积孵育相关的问题，生物反应器可以包括湿度室或避免脱水的其它手段以及用于进入端口的基本上流体密封的封闭件，以避免将气泡引入培养腔。 小批量生物反应器允许长期维持组织分化状态在文化中。 还提供了使用生物反应器来孵育细胞或组织的方法，包括产生化学组成对保持在长期培养物中的分化细胞或组织样品的生物学效应的分子谱的方法。
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公开(公告)号：US09850458B2
公开(公告)日：2017-12-26
申请号：US13990198
申请日：2011-12-07
摘要： There is provided a bioreactor which is provided with a lid (13) that facilitates access to the incubation cavity. Specifically the end wall of the incubation cavity is constituted by the lid (13) so that removal of the cap renders the incubation cavity fully accessible.
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公开(公告)号：US20130260450A1
公开(公告)日：2013-10-03
申请号：US13990198
申请日：2011-12-07
IPC分类号： C12M1/26
摘要： There is provided a bioreactor which is provided with a lid (13) that facilitates access to the incubation cavity. Specifically the end wall of the incubation cavity is constituted by the lid (13) so that removal of the cap renders the incubation cavity fully accessible.
摘要翻译： 提供了一种生物反应器，其具有便于进入孵化腔的盖子（13）。 特别地，孵化腔的端壁由盖（13）构成，使得帽的移除使得孵育腔完全可接近。
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公开(公告)号：US09221860B2
公开(公告)日：2015-12-29
申请号：US13878158
申请日：2010-10-07
申请人： Elizabeth Joubert , Stephen John Fey , Johan Louw , Trond Ulven , Rahul Tyagi
发明人： Elizabeth Joubert , Stephen John Fey , Johan Louw , Trond Ulven , Rahul Tyagi
CPC分类号： C07H15/203 , C07H15/18 , C07H15/26
摘要： There is provided an antidiabetic enolic glucoside of phenylpyruvic acid and derivatives thereof for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pre-diabetic or have diabetes, obesity and/or syndrome X. Hence the compounds of the present invention help to manage blood sugar levels, i.e. helping the body by balancing the blood sugar levels; helping to keep balanced blood glucose levels, particularly in humans with diabetes; aiding by enhancing the glucose uptake by the cells and by reducing sugar levels, thus improving or restoring the glucose tolerance; optimizing the glycemic response; normalizing the glucose tolerance.
摘要翻译： 提供苯丙酮酸及其衍生物的抗糖尿病烯醇葡糖苷及其衍生物，用作药物，尤其是正常血糖药，即将肥胖，糖尿病前期或糖尿病，肥胖和/或综合征X的哺乳动物血糖水平降低至正常水平 因此，本发明的化合物有助于控制血糖水平，即通过平衡血糖水平来帮助身体; 有助于保持平衡的血糖水平，特别是在患有糖尿病的人中; 通过增强细胞的葡萄糖摄取和降低糖水平，从而改善或恢复葡萄糖耐量来辅助; 优化血糖反应; 正常化葡萄糖耐量。
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公开(公告)号：US20130310331A1
公开(公告)日：2013-11-21
申请号：US13878158
申请日：2010-10-07
申请人： Elizabeth Joubert , Stephen John Fey , Johan Louw , Trond Ulven , Rahul Tyagi
发明人： Elizabeth Joubert , Stephen John Fey , Johan Louw , Trond Ulven , Rahul Tyagi
CPC分类号： C07H15/203 , C07H15/18 , C07H15/26
摘要： There is provided an antidiabetic enolic glucoside of phenylpyruvic acid and derivatives thereof for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pre-diabetic or have diabetes, obesity and/or syndrome X. Hence the compounds of the present invention help to manage blood sugar levels, i.e. helping the body by balancing the blood sugar levels; helping to keep balanced blood glucose levels, particularly in humans with diabetes; aiding by enhancing the glucose uptake by the cells and by reducing sugar levels, thus improving or restoring the glucose tolerance; optimizing the glycemic response; normalizing the glucose tolerance.
摘要翻译： 提供了苯丙酮酸及其衍生物的抗糖尿病烯醇葡糖苷及其衍生物，用作药物，尤其是正常血糖药，即将肥胖，糖尿病前期或糖尿病，肥胖和/或综合征X的哺乳动物血糖水平降低至正常水平 因此，本发明的化合物有助于控制血糖水平，即通过平衡血糖水平来帮助身体; 有助于保持平衡的血糖水平，特别是在患有糖尿病的人中; 通过增强细胞的葡萄糖摄取和降低糖水平，从而改善或恢复葡萄糖耐量来辅助; 优化血糖反应; 正常化葡萄糖耐量。
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公开(公告)号：US20110045108A1
公开(公告)日：2011-02-24
申请号：US12531028
申请日：2008-03-11
CPC分类号： A61K36/48 , A61K31/352 , A61K31/7048 , A61K36/00 , A61K2300/00
摘要： Novel and useful compositions derived from honeybush plant extract for treating diabetes are provided. It has been found that the plant extract of the present invention exhibit a superior antidiabetic effect when administered in an amount from about 1 milligram to about 5 milligrams, preferably to about 2.5 milligrams, per kilogram body weight.
摘要翻译： 提供了源自蜜蜂植物提取物治疗糖尿病的新颖有用的组合物。 已经发现，当以每千克体重约1毫克至约5毫克，优选至约2.5毫克的量施用时，本发明的植物提取物显示出优异的抗糖尿病作用。
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公开(公告)号：US09574166B2
公开(公告)日：2017-02-21
申请号：US13816997
申请日：2011-07-29
申请人： Stephen John Fey
发明人： Stephen John Fey
摘要： A bioreactor or culture vessel for incubation of one or more cell cultures, tissue biopsies, cell clusters, tissue-like structures, “prototissues” or similar samples is described. The bioreactor comprises an incubation chamber, a liquid reservoir and conduction means separated from each other by semipermeable membranes. Specifically, the invention provides a humidity chamber design which simplifies the construction of the bioreactor.
摘要翻译： 描述了用于孵育一种或多种细胞培养物，组织活检，细胞簇，组织样结构，“原始组织”或类似样品的生物反应器或培养容器。 生物反应器包括孵育室，液体储存器和通过半透膜隔离的传导装置。 具体地说，本发明提供一种简化生物反应器结构的湿度室设计。
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公开(公告)号：US20120251643A1
公开(公告)日：2012-10-04
申请号：US13493614
申请日：2012-06-11
CPC分类号： A61K36/48 , A61K31/352 , A61K31/7048 , A61K36/00 , A61K2300/00
摘要： Novel and useful compositions derived from honeybush plant extract for treating diabetes are provided. It has been found that the plant extract of the present invention exhibit a superior antidiabetic effect when administered in an amount from about 1 milligram to about 5 milligrams, preferably to about 2.5 milligrams, per kilogram body weight.
摘要翻译： 提供了源自蜜蜂植物提取物治疗糖尿病的新颖有用的组合物。 已经发现，当以每千克体重约1毫克至约5毫克，优选至约2.5毫克的量施用时，本发明的植物提取物显示出优异的抗糖尿病作用。
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