公开(公告)号：US20240254425A1

公开(公告)日：2024-08-01

申请号：US18415313

申请日：2024-01-17

申请人： NODEXUS INC.

发明人： Hany Nassef ,  Anand Kesavaraju ,  Karthik Balakrishnan ,  Zhiliang Wan

IPC分类号： C12M1/34 ,  C12M1/00 ,  C12M1/26 ,  C12M3/00 ,  C12M3/06

CPC分类号： C12M41/46 ,  C12M23/16 ,  C12M23/40 ,  C12M23/42 ,  C12M29/06 ,  C12M33/14

摘要： Systems and methods for rapid detection and sorting of target particles based on specific characteristics are provided. Optical, electrical, or other detection of the target characteristic in a target particle in a microfluidic sample flow can be used to identify that target particle which can then trigger accurate downstream diversion and isolation of the target particle from the sample flow.

公开(公告)号：US12023664B2

公开(公告)日：2024-07-02

申请号：US16642585

申请日：2018-08-31

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： J. Peter Rubin

IPC分类号： B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26

CPC分类号： B01L3/5021 ,  C12M33/14 ,  C12M45/05 ,  C12M45/22 ,  B01L7/50 ,  B01L2200/026 ,  B01L2300/021 ,  B01L2300/0609 ,  B01L2300/0681

摘要： Methods, devices, and kits are provided for use in washing or cryopreserving live cells or tissue, such as fat graft tissue.

公开(公告)号：US20240200012A1

公开(公告)日：2024-06-20

申请号：US18410607

申请日：2024-01-11

申请人： Global Life Sciences Solutions USA LLC

发明人： Weston Blaine Griffin ,  Alex D Corwin ,  Xiaohua Zhang ,  Reginald Donovan Smith ,  Zhen Liu ,  Chengkun Zhang ,  Vandana Keskar ,  Brian Michael Davis ,  Kashan Shaikh

IPC分类号： C12M1/26 ,  C12M1/00 ,  C12M1/04 ,  C12M1/12 ,  C12M1/34

CPC分类号： C12M33/14 ,  C12M23/24 ,  C12M25/02 ,  C12M29/10 ,  C12M41/44 ,  C12M47/04

摘要： A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.

公开(公告)号：US20240182836A1

公开(公告)日：2024-06-06

申请号：US18282425

申请日：2022-01-31

申请人： Yokogawa Electric Corporation

发明人： Kentaro Inoue ,  Tomoyuki Taguchi ,  Hiroyuki Katayama ,  Yasuhiro Matsui

IPC分类号： C12M1/26 ,  B01D35/06 ,  B01D35/16 ,  C12N7/00

CPC分类号： C12M33/14 ,  B01D35/06 ,  B01D35/16 ,  C12N7/00

摘要： A filtration member 110 including pores having a pore diameter through which microorganisms may pass and configured to have a positive charge or a negative charge upon application of a voltage.

公开(公告)号：US11970684B2

公开(公告)日：2024-04-30

申请号：US18153689

申请日：2023-01-12

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Steven Skerlos ,  Lutgarde Raskin ,  Timothy Fairley-Wax ,  Nishant Jalgaonkar

IPC分类号： C12M1/00 ,  C02F3/10 ,  C02F3/12 ,  C02F3/28 ,  C12M1/12 ,  C12M1/26 ,  C12M3/06 ,  C12P5/02

CPC分类号： C12M29/26 ,  C02F3/10 ,  C02F3/1268 ,  C02F3/2806 ,  C02F3/2853 ,  C12M23/06 ,  C12M25/00 ,  C12M27/14 ,  C12M33/14 ,  C12P5/023

摘要： The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to die reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent.

公开(公告)号：US11958018B2

公开(公告)日：2024-04-16

申请号：US17091616

申请日：2019-05-28

申请人： REPLIGEN CORPORATION

发明人： Michael Bransby ,  Derek Carroll ,  Philip Yuen ,  Ralf Kuriyel

IPC分类号： B01D61/14 ,  B01D63/02 ,  B01D63/06 ,  B01D65/08 ,  C12M1/26

CPC分类号： B01D63/06 ,  B01D61/147 ,  B01D63/02 ,  B01D65/08 ,  C12M33/14 ,  B01D2315/10 ,  B01D2321/20

摘要： The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.

公开(公告)号：US11912741B2

公开(公告)日：2024-02-27

申请号：US16837126

申请日：2020-04-01

申请人： Genzyme Corporation

发明人： Michael Coolbaugh ,  Tarl Vetter ,  Chad Varner ,  Kevin Brower

IPC分类号： C07K1/36 ,  C12M1/26 ,  C12M1/12

CPC分类号： C07K1/36 ,  C12M33/14 ,  C12M37/02

摘要： The present disclosure relates to methods and systems for the continuous production of recombinant proteins. In particular embodiments, the disclosure relates to methods and systems using capture chromatography, post-capture chromatography, virus filtration, and ultrafiltration/diafiltration for the continuous production of recombinant proteins.

公开(公告)号：US11890557B2

公开(公告)日：2024-02-06

申请号：US17740710

申请日：2022-05-10

申请人： Life Technologies Corporation

发明人： Charles R. Rhodes

IPC分类号： B01D29/27 ,  C12M1/12 ,  C12M1/00 ,  C12M1/26 ,  B01D35/027

CPC分类号： B01D29/27 ,  C12M23/14 ,  C12M23/28 ,  C12M25/16 ,  C12M29/04 ,  C12M33/14 ,  C12M47/02 ,  B01D35/027

摘要： A filter bag assembly includes: a flexible first sheet; a flexible second sheet overlying and secured to the first sheet so that a compartment is formed therebetween; a porous filter sheet disposed between the first sheet and the second sheet so as to divide the compartment into a first compartment and a second compartment; a first port secured to the second sheet so as to communicate directly with the first compartment; and a second port secured to the second sheet so as to communicate directly with the second compartment, the second port being spaced apart from the first port. The porous filter sheet is disposed so that fluid entering the first compartment through the first port must pass through the filter sheet before entering the second compartment or exiting through the second port.

公开(公告)号：US20240034980A1

公开(公告)日：2024-02-01

申请号：US18013283

申请日：2022-10-21

申请人： Jun Seok LEE

发明人： Jun Seok LEE

IPC分类号： C12M1/26 ,  C12M1/00

CPC分类号： C12M33/04 ,  C12M33/14 ,  C12M23/50 ,  C12M33/12

摘要： A screen changing device is proposed. The screen changing device includes a first housing and a second housing configured to be rotated with respect to the first housing. The screen changing device can transit from a first configuration in which a first screen is aligned with a first connector and a second connector to a second configuration in which the first screen is not aligned with the first connector and the second connector and a second screen is aligned with the first connector and the second connector.

公开(公告)号：US20240002778A1

公开(公告)日：2024-01-04

申请号：US18368281

申请日：2023-09-14

申请人： CORNING INCORPORATED

发明人： Gregory Roger Martin ,  Allison Jean Tanner

IPC分类号： C12M1/00 ,  C12M1/26 ,  C12N5/00

CPC分类号： C12M47/02 ,  C12M33/14 ,  C12N5/0075

摘要： A cell separation device configured for separating cells from microcarriers or spheroids in a liquid is provided. The cell separation device includes a vessel comprising a first port, a second port, and a cavity; and a porous mesh disposed within the cavity to divide the cavity into a first compartment and a second compartment, wherein the first port is in communication with the first compartment of the cavity, the first port located to a first side of the porous mesh, wherein the second port is in communication with the second compartment of the cavity, the second port located to a second side of the porous mesh, and wherein the porous mesh is positioned within the cavity to have a substantially vertical orientation or an inclined orientation with respect to a flow of liquid through the porous mesh.