公开(公告)号：US07109229B2

公开(公告)日：2006-09-19

申请号：US10344245

申请日：2001-09-24

Applicant: Thomas Albert Engler ,  Kelly Wayne Furness ,  Sushant Malhotra ,  Stephen Lyle Briggs ,  Harold Burns Brooks ,  David K yes Clawson ,  Concepcion Sanchez-Martinez ,  Faming Zhang ,  Guoxin Zhu

Inventor： Thomas Albert Engler ,  Kelly Wayne Furness ,  Sushant Malhotra ,  Stephen Lyle Briggs ,  Harold Burns Brooks ,  David K yes Clawson ,  Concepcion Sanchez-Martinez ,  Faming Zhang ,  Guoxin Zhu

IPC: A61K31/40 ,  C07D481/00

CPC classification number: C07D403/14 ,  C07D487/14

Abstract: The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).

Abstract translation: 本文公开的化合物是式（I）的吲哚并唑，其是有效的CDK4抑制剂，并且可用于治疗包括癌症的细胞增殖性疾病。 式（I）。