Parallel Mass Analysis
    1.
    发明申请

    公开(公告)号:US20130327934A1

    公开(公告)日:2013-12-12

    申请号:US13970310

    申请日:2013-08-19

    IPC分类号: H01J49/00

    CPC分类号: H01J49/009 H01J49/425

    摘要: A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.

    Electrostatic Trap
    2.
    发明申请
    Electrostatic Trap 有权
    静电捕集阱

    公开(公告)号:US20130126724A1

    公开(公告)日:2013-05-23

    申请号:US13737771

    申请日:2013-01-09

    IPC分类号: H01J49/28 H01J49/00

    摘要: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′ (r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 n radians over an ion detection period Tm.

    摘要翻译: 公开了诸如轨道捕获器的静电捕获器,具有电极结构。 产生形式为U'(r,Phi,z)的静电捕获场以捕获陷阱内的离子,使得它们经历同步振荡。 捕获场U'(r,Phi,z)是对于理想场U(r,Phi,z)的扰动W的结果,在理想场U(r,Phi,z)中,例如在轨道阱的情况下是对数的。 扰动W可以以各种方式引入,例如通过使陷波器的几何形状变形,使得其不再遵循理想场U(r,Phi,z)的等电位,或者通过添加失真场(电或 磁性)。 扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于2n弧度的绝对相位扩展。

    Multiple ion injection in mass spectrometry
    3.
    发明授权
    Multiple ion injection in mass spectrometry 有权
    多重离子注入质谱法

    公开(公告)号:US08686350B2

    公开(公告)日:2014-04-01

    申请号:US13853603

    申请日:2013-03-29

    IPC分类号: H01J49/00

    摘要: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analyzed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

    摘要翻译: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说,尽管并非排他地,本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法,其包括以下顺序步骤:在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

    Multiple Ion Injection in Mass Spectrometry
    4.
    发明申请
    Multiple Ion Injection in Mass Spectrometry 有权
    质谱中的多离子注入

    公开(公告)号:US20130228679A1

    公开(公告)日:2013-09-05

    申请号:US13853603

    申请日:2013-03-29

    IPC分类号: H01J49/00

    摘要: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

    摘要翻译: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说,尽管并非排他地,本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法,其包括以下顺序步骤:在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

    Multiple ion injection in mass spectrometry
    5.
    发明授权
    Multiple ion injection in mass spectrometry 有权
    多重离子注入质谱法

    公开(公告)号:US08410424B2

    公开(公告)日:2013-04-02

    申请号:US13008790

    申请日:2011-01-18

    IPC分类号: B01D59/44

    摘要: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

    摘要翻译: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说,尽管并非排他地,本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法,其包括以下顺序步骤:在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

    Electrostatic trap
    6.
    发明授权
    Electrostatic trap 有权
    静电诱捕器

    公开(公告)号:US08716654B2

    公开(公告)日:2014-05-06

    申请号:US13737771

    申请日:2013-01-09

    IPC分类号: H01J49/26

    摘要: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′ (r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.

    摘要翻译: 公开了诸如轨道捕获器的静电捕获器,具有电极结构。 产生U'(r,Φ,z)形式的静电捕获场,以捕获陷阱内的离子,使它们经历同步振荡。 捕获场U'(r,Φ,z)是对于理想场U(r,Φ,z)的扰动W的结果,其在轨道捕获的情况下例如是对数的。 扰动W可以以各种方式引入,例如通过使陷波器的几何形状变形,使得其不再遵循理想场U(r,Φ,z)的等电位,或者通过添加失真场(电或 磁性)。 扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

    Parallel mass analysis
    7.
    发明授权
    Parallel mass analysis 有权
    平行质量分析

    公开(公告)号:US08692189B2

    公开(公告)日:2014-04-08

    申请号:US13970310

    申请日:2013-08-19

    IPC分类号: H01J49/26 H01J27/02

    CPC分类号: H01J49/009 H01J49/425

    摘要: A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.

    摘要翻译: 提供了一种质谱系统和方法。 来自离子源的离子存储在第一离子存储装置和第二离子存储装置中。 在第一喷射时间段期间,离子从第一离子存储装置喷射到第一质量分析装置,以在第一分析时间段期间进行分析。 在第二喷射时间段期间,离子从第二离子存储装置喷射到第二质量分析装置。 离子存储装置串联连接,使得第一离子存储装置的离子传送孔与第二离子存储装置的离子传送孔连通。 第一分析时间段和第二喷射时间段至少部分重叠。