公开(公告)号：US20190122874A1

公开(公告)日：2019-04-25

申请号：US16167806

申请日：2018-10-23

申请人： Florida State University Research Foundation, Inc. ,  St. Louis University

发明人： Michael G. Roper ,  James L. Edwards

IPC分类号： H01J49/00 ,  H01J49/16 ,  H01J49/42 ,  G01N30/72

CPC分类号： H01J49/009 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/623 ,  H01J49/0027 ,  H01J49/0036 ,  H01J49/0431 ,  H01J49/165 ,  H01J49/4225 ,  G01N30/32

摘要： Provided herein are methods for multiplexed sample analysis by mass spectrometry. The methods may be performed without the need for chemical tagging. The methods also may include the analogous use of frequency modulation to multiplex mass spectrometric analysis, which may be referred to as frequency-modulated continuous flow analysis electrospray ionization mass spectrometry (FM-CFA-ESI-MS).

公开(公告)号：US20180286655A1

公开(公告)日：2018-10-04

申请号：US15518408

申请日：2015-10-07

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： Chang Joon Park ,  Sang Jung AHN ,  Cheolsu HAN ,  Keu Chan LEE ,  Seok Rae YOON

IPC分类号： H01J49/14 ,  H01J49/06 ,  H01J49/42 ,  H01J49/00

CPC分类号： H01J49/147 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/009 ,  H01J49/0095 ,  H01J49/061 ,  H01J49/4225

摘要： The present invention relates to a particle beam mass spectrometer and particle measurement method by means of same. More particularly, the present invention relates to a particle beam mass spectrometer including: a particle focusing unit focusing a particle beam induced by gas flow; an electron gun forming a charged particle beam by accelerating thermal electrons to ionize the particle beam focused by the particle focusing unit; a deflector deflecting the charged particle beam according to kinetic energy to charge ratio; and a sensing unit measuring a current induced by the deflected charged particle beam, wherein the deflector includes at least one particle beam separation electrode provided at each of opposite sides with respect to a progress axis of the charged particle beam before being deflected.

公开(公告)号：US09905410B2

公开(公告)日：2018-02-27

申请号：US14959795

申请日：2015-12-04

申请人： Agilent Technologies, Inc.

发明人： Trygve Ristroph ,  Julia Zaks

IPC分类号： H01J49/40 ,  H01J49/00

CPC分类号： H01J49/40 ,  H01J49/009

摘要： A time-of-flight mass spectrometer (TOF-MS) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a TOF analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing. The dispersion may be carried out before, at, or after an ion accelerator of the TOF analyzer. Ion packets may be accelerated into the flight tube at a multi-pulse firing rate. Tandem MS may be implemented on parallel ion beams simultaneously.

公开(公告)号：US09812307B2

公开(公告)日：2017-11-07

申请号：US15021108

申请日：2014-09-10

申请人： Thermo Fisher Scientific (Bremen) GmbH

发明人： Alexander Alekseevich Makarov

IPC分类号： H01J49/40 ,  H01J49/00

CPC分类号： H01J49/005 ,  H01J49/0036 ,  H01J49/0077 ,  H01J49/009 ,  H01J49/40

摘要： A mass spectrometer comprises: an ion source that generates ions having an initial range of mass-to-charge ratios; an auxiliary ion detector, downstream from the ion source that receives a plurality of first ion samples derived from the ions generated by the ion source and determines a respective ion current measurement for each of the plurality of first ion samples; a mass analyzer, downstream from the ion source that receives a second ion sample derived from the ions generated by the ion source and to generate mass spectral data by mass analysis of the second ion sample; and an output stage that establishes an abundance measurement associated with at least some of the ions generated by the ion source based on the ion current measurements determined by the auxiliary ion detector.

公开(公告)号：US20160071709A1

公开(公告)日：2016-03-10

申请号：US14483098

申请日：2014-09-10

申请人： Paul I. Hendricks

发明人： Paul I. Hendricks

IPC分类号： H01J49/00 ,  H01J49/06

CPC分类号： H01J49/0013 ,  H01J49/009 ,  H01J49/4225 ,  H01J49/424

摘要： Apparatus and methods for controlling miniaturized arrays of ion traps, including cylindrical ion traps, rectilinear ion traps, and linear ion traps. Improved methods for applying supplemental AC signals to individual ion traps in an ion trap array. Methods of organizing ion trap arrays and operating the arrays in a manner to improve sensitivity, resolution and mass accuracy. Techniques for performing simultaneous detection of multiple compounds from ion trap arrays. Optimization of ion trap performance by dynamic optimization or adjustment of RF trapping frequency and voltage amplitude.

摘要翻译： 用于控制离子阱的小型化阵列的装置和方法，包括圆柱形离子阱，直线离子阱和线性离子阱。 将补充AC信号用于离子阱阵列中的各个离子阱的改进方法。 组织离子阱阵列并以提高灵敏度，分辨率和质量精度的方式操作阵列的方法。 用于从离子阱阵列同时检测多种化合物的技术。 通过动态优化或调整RF捕获频率和电压振幅来优化离子阱性能。

公开(公告)号：US20160035549A1

公开(公告)日：2016-02-04

申请号：US14776910

申请日：2014-03-07

申请人： THERMO FINNIGAN LLC

发明人： Michael W. SENKO ,  Justin BLETHROW ,  Shannon Eliuk DIXON ,  Tonya SECOND ,  Vladimir ZABROUSKOV ,  Eric HEMENWAY

IPC分类号： H01J49/00

CPC分类号： H01J49/0031 ,  H01J49/005 ,  H01J49/009 ,  H01J49/061

摘要： A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list. The method enables more efficient utilization of analyzer time.

摘要翻译： 公开了混合质谱仪设计和结构以及操作质谱仪的方法。 根据一种操作方法，以有序序列确定要分析的多个离子种类中的每一种的分析时间，并且基于前面的分析时间为至少一些离子种类计算注入时间 有序列表中的离子物种。 该方法可以更有效地利用分析仪的时间。

公开(公告)号：US20160005578A1

公开(公告)日：2016-01-07

申请号：US14763520

申请日：2014-01-28

申请人： WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

发明人： CHRISTINA KOEPPEN ,  OLGA REIFSCHNEIDER ,  CHRISTOPH ALEXANDER WEHE ,  MICHAEL SPERLING ,  UWE KARST

IPC分类号： H01J49/04 ,  H01J49/10 ,  H01J49/00

CPC分类号： H01J49/0463 ,  H01J49/0031 ,  H01J49/009 ,  H01J49/105 ,  H01J49/107

摘要： An apparatus for mass spectrometry includes a laser ablation sampler comprising a laser ablation chamber and a laser which produces a laser beam. The laser irradiates and ablates a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material. A transfer tube system comprising transfer tubes connect the laser ablation sample with, and provides a parallel and simultaneous transport of the ablated sample material to, each of a soft and a hard ionization source. The soft and hard ionization sources interact with the ablated sample material to respectively generate ion populations having a mass-to-charge ratio distribution. These respective mass-to-charge ratio distributions are respectively transmitted to a molecular mass spectrometer and to an elemental mass spectrometer which provide information on the mass-to-charge ratio distribution. The mass-to-charge ratio distributions are used to characterize a composition of the ablated sample material.

摘要翻译： 用于质谱的装置包括激光烧蚀取样器，其包括激光烧蚀室和产生激光束的激光器。 激光从放置在激光烧蚀室内的样品照射并消融材料，以产生消融的样品材料。 传输管系统包括传送管，其将激光烧蚀样品与软和硬质电离源中的每一个连接并且提供平行并同时传送烧蚀的样品材料。 软和硬电离源与烧蚀的样品材料相互作用以分别产生具有质荷比分布的离子群。 这些各自的质荷比分布分别传输到分子质谱仪和元素质谱仪，其提供有关质荷比分布的信息。 质荷比分布用于表征烧蚀样品材料的组成。

公开(公告)号：US20150034816A1

公开(公告)日：2015-02-05

申请号：US14379712

申请日：2013-03-18

申请人： Bruker Chemical Analysis BV

发明人： Iouri Kalinitchenko

IPC分类号： H01J49/06 ,  H01J49/26

CPC分类号： H01J49/067 ,  H01J49/009 ,  H01J49/105 ,  H01J49/26

摘要： There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway.

摘要翻译： 提供了一种用于在质谱仪中对离子进行采样的界面，该界面布置成从离子源接收一定数量的离子并从其形成多于一个的离子束，每个离子束沿相应的期望路径被引导。

公开(公告)号：US08513595B2

公开(公告)日：2013-08-20

申请号：US13164693

申请日：2011-06-20

申请人： Alexander A. Makarov ,  Stevan Horning

发明人： Alexander A. Makarov ,  Stevan Horning

IPC分类号： H01J49/26 ,  H01J27/02

CPC分类号： H01J49/009 ,  H01J49/425

摘要： A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.

公开(公告)号：US20130105681A1

公开(公告)日：2013-05-02

申请号：US13287849

申请日：2011-11-02

申请人： Viatcheslav V. KOVTOUN

发明人： Viatcheslav V. KOVTOUN

IPC分类号： H01J49/40 ,  H01J49/04 ,  H01J49/34

CPC分类号： H01J49/0045 ,  H01J49/009 ,  H01J49/0481 ,  H01J49/06 ,  H01J49/4295

摘要： A device and associated method are disclosed for interfacing an ion trap to a pulsed mass analyzer (such as a time-of-flight analyzer) in a mass spectrometer. The device includes a plurality of separate confinement cells and structures for directing ions into a selected one of the confinement cells. Ions are ejected from the ion trap in a series of temporally successive ion packets. Each ion packet (which may consist of ions of like mass-to-charge ratio), is received by the ion interface device, fragmented to form product ions, and then stored and cooled in the selected confinement cell. Storage and cooling of the ion packet occurs concurrently with the receipt and storage of at least one later-ejected ion packet. After a predetermined cooling period, the ion packet is released to the mass analyzer for acquisition of a mass spectrum.

摘要翻译： 公开了一种用于在质谱仪中将离子阱与脉冲质量分析器（例如飞行时间分析器）接口的装置和相关方法。 该装置包括多个单独的约束单元和用于将离子引导到选定的约束单元中的结构。 离子从离子阱排出一系列时间上连续的离子包。 每个离子包（其可以由具有类似质荷比的离子组成）被离子界面装置接收，碎片化以形成产物离子，然后在选定的限制电池中储存和冷却。 离子包的存储和冷却与至少一个稍后排出的离子包的接收和存储同时发生。 在预定的冷却时间之后，离子包被释放到质量分析器以获取质谱。