公开(公告)号：US20160244495A1

公开(公告)日：2016-08-25

申请号：US15078885

申请日：2016-03-23

申请人： Alyssa Panitch ,  John Eric Paderi ,  Kinam Park ,  Katherine Allison Stuart ,  Steve Higbee

发明人： Alyssa Panitch ,  John Eric Paderi ,  Kinam Park ,  Katherine Allison Stuart ,  Steve Higbee

IPC分类号： C07K14/47 ,  A61L27/54 ,  A61L27/22 ,  C07K9/00

CPC分类号： C07K14/4725 ,  A61K38/00 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/42 ,  C07K9/00 ,  C07K9/001 ,  C07K14/00 ,  C07K14/78

摘要： This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

公开(公告)号：US08846003B2

公开(公告)日：2014-09-30

申请号：US12934551

申请日：2009-03-27

申请人： Alyssa Panitch ,  John E. Paderi ,  Kinam Park ,  Katherine Stuart ,  Steve Higbee

发明人： Alyssa Panitch ,  John E. Paderi ,  Kinam Park ,  Katherine Stuart ,  Steve Higbee

IPC分类号： A61L27/54 ,  C07K14/78 ,  A61L27/38 ,  A61L27/24 ,  C07K14/47 ,  A61K38/00

CPC分类号： C07K14/4725 ,  A61K38/00 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/42 ,  C07K9/00 ,  C07K9/001 ,  C07K14/00 ,  C07K14/78

摘要： This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

摘要翻译： 本发明涉及胶原结合合成肽聚糖和包含胶原基质和胶原结合合成肽聚糖的工程胶原基质，其中胶原结合合成肽聚糖可以是异常的，或者可以与氨基酸序列的一部分具有氨基酸同源性 蛋白质或调节胶原纤维发生的蛋白多糖。 本发明还涉及包含这种胶原结合合成肽聚糖或工程化胶原基质的试剂盒，化合物，组合物和工程化移植物构建体及其制备和使用方法。

公开(公告)号：US20110020298A1

公开(公告)日：2011-01-27

申请号：US12934551

申请日：2009-03-27

申请人： Alyssa Panitch ,  John E. Paderi ,  Kinam Park ,  Katherine Stuart ,  Steve Higbee

发明人： Alyssa Panitch ,  John E. Paderi ,  Kinam Park ,  Katherine Stuart ,  Steve Higbee

IPC分类号： A61K35/12 ,  C07K14/78 ,  A61P7/02 ,  A61K38/36

CPC分类号： C07K14/4725 ,  A61K38/00 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/42 ,  C07K9/00 ,  C07K9/001 ,  C07K14/00 ,  C07K14/78

摘要： This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

摘要翻译： 本发明涉及胶原结合合成肽聚糖和包含胶原基质和胶原结合合成肽聚糖的工程胶原基质，其中胶原结合合成肽聚糖可以是异常的，或者可以与氨基酸序列的一部分具有氨基酸同源性 蛋白质或调节胶原纤维发生的蛋白多糖。 本发明还涉及包含这种胶原结合合成肽聚糖或工程化胶原基质的试剂盒，化合物，组合物和工程化移植物构建体及其制备和使用方法。