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公开(公告)号：US20110189663A1
公开(公告)日：2011-08-04
申请号：US12529942
申请日：2008-03-05
Applicant: Michelle Cotterchio , Steven Gallinger , Celia Greenwood , Thomas J. Hudson , Brent W. Zanke , Michael Phillips , Saravanan Sundararajan , Alexandre Montpetit , Phillippe Laflamme , Vincent Ferretti
Inventor： Michelle Cotterchio , Steven Gallinger , Celia Greenwood , Thomas J. Hudson , Brent W. Zanke , Michael Phillips , Saravanan Sundararajan , Alexandre Montpetit , Phillippe Laflamme , Vincent Ferretti
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
Abstract: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).
Abstract translation: 公开了用于鉴定具有发生结肠直肠癌风险改变的个体的方法，包括检测单核苷酸多态性（SNP）。
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公开(公告)号：US08153369B2
公开(公告)日：2012-04-10
申请号：US12303410
申请日：2007-06-05
Applicant: Michelle Cotterchio , Steven Gallinger , Celia Greenwood , Thomas J. Hudson , Brent W. Zanke , Michael Phillips , Saravanan Sundararajan , Alexandre Montpetit , Phillippe Laflamme , Vincent Ferretti
Inventor： Michelle Cotterchio , Steven Gallinger , Celia Greenwood , Thomas J. Hudson , Brent W. Zanke , Michael Phillips , Saravanan Sundararajan , Alexandre Montpetit , Phillippe Laflamme , Vincent Ferretti
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/136
Abstract: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).
Abstract translation: 公开了用于鉴定具有发生结肠直肠癌风险改变的个体的方法，包括检测单核苷酸多态性（SNP）。
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公开(公告)号：US20100047782A1
公开(公告)日：2010-02-25
申请号：US12303410
申请日：2007-06-05
Applicant: Michelle Cotterchio , Steven Gallinger , Celia Greenwood , Thomas J. Hudson , Brent W. Zanke , Michael Phillips , Saravanan Sundararajan , Alexandre Montpetit , Phillippe Laflamme , Vincent Ferretti
Inventor： Michelle Cotterchio , Steven Gallinger , Celia Greenwood , Thomas J. Hudson , Brent W. Zanke , Michael Phillips , Saravanan Sundararajan , Alexandre Montpetit , Phillippe Laflamme , Vincent Ferretti
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/136
Abstract: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).
Abstract translation: 公开了用于鉴定具有发生结肠直肠癌风险改变的个体的方法，包括检测单核苷酸多态性（SNP）。
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公开(公告)号：US5663481A
公开(公告)日：1997-09-02
申请号：US102905
申请日：1993-08-06
Applicant: Steven Gallinger , Nobumichi Hozumi , John C. Roder , Jasbir S. Sandhu , Baruch Shpitz
Inventor： Steven Gallinger , Nobumichi Hozumi , John C. Roder , Jasbir S. Sandhu , Baruch Shpitz
CPC classification number: A01K67/0271 , A61K39/08 , C07K16/18 , A61K38/00
Abstract: The present invention relates to a non-human chimeric mammal having characteristics of a functional human immune system and having functional human lymphocytes reconstituted in the mammal's lymphopoietic tissue, particularly the spleen. The invention also relates to a method of preparing a non-human chimeric mammal, having characteristics of a functional human immune system, by engraftment of human peripheral blood leukocytes into an immunocompromised mammal. Use of the chimeric mammal as a model of the human immune system is described.
Abstract translation: 本发明涉及具有功能性人类免疫系统特征且具有在哺乳动物的淋巴组织，特别是脾中重构的功能性人淋巴细胞的非人嵌合哺乳动物。 本发明还涉及通过将人外周血白细胞植入免疫受损的哺乳动物中制备具有功能性人免疫系统特征的非人嵌合哺乳动物的方法。 描述了嵌合哺乳动物作为人免疫系统模型的用途。
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