公开(公告)号：US20190040382A1

公开(公告)日：2019-02-07

申请号：US15519482

申请日：2015-10-16

申请人： Frank J. STEEMERS ,  Kevin L. GUNDERSON ,  Fan ZHANG ,  Jason Richard BETLEY ,  Niall Anthony GORMLEY ,  Wouter MEULEMAN ,  Jacqueline WEIR ,  Avgousta IOANNOU ,  Gareth JENKINS ,  Rosamond JACKSON ,  Natalie MORRELL ,  Dmitry K. POKHOLOK ,  Steven J. NORBERG ,  Molly HE ,  Amirali KIA ,  Igor GORYSHIN ,  Rigo PANTOJA ,  ILLUMINA CAMBRIDGE LIMITED

发明人： Frank J. Steemers ,  Kevin L. Gunderson ,  Fan Zhang ,  Jason Richard Betley ,  Niall Anthony Gormley ,  Wouter Meuleman ,  Jacqueline Weir ,  Avgousta Ioannou ,  Gareth Jenkins ,  Rosamond Jackson ,  Natalie Morrell ,  Dmitry K. Pokholok ,  Steven J. Norberg ,  Molly He ,  Amirali Kia ,  Igor Goryshin ,  Rigo Pantoja

IPC分类号： C12N15/10 ,  C12Q1/68

摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.