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1.发明授权公开(公告)号：US09040678B2
公开(公告)日：2015-05-26
申请号：US13565400
申请日：2012-08-02
IPC分类号： C07H21/00 , C12N15/10 , C07D495/04 , C12Q1/68
CPC分类号： C07H1/06 , C07D495/04 , C07H1/00 , C07H21/00 , C12N15/1003 , C12Q1/6811
摘要： Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.
摘要翻译： 本公开的实施方案包括用于官能化分子（例如具有官能团的寡核苷酸）的方法和组合物，包括用于亲和方法的多组氨酸标签。 一些实施方案包括通过交换功能性标签来修饰和纯化分子的复杂混合物的方法。
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公开(公告)号：US20190040382A1
公开(公告)日：2019-02-07
申请号：US15519482
申请日：2015-10-16
申请人： Frank J. STEEMERS , Kevin L. GUNDERSON , Fan ZHANG , Jason Richard BETLEY , Niall Anthony GORMLEY , Wouter MEULEMAN , Jacqueline WEIR , Avgousta IOANNOU , Gareth JENKINS , Rosamond JACKSON , Natalie MORRELL , Dmitry K. POKHOLOK , Steven J. NORBERG , Molly HE , Amirali KIA , Igor GORYSHIN , Rigo PANTOJA , ILLUMINA CAMBRIDGE LIMITED
发明人： Frank J. Steemers , Kevin L. Gunderson , Fan Zhang , Jason Richard Betley , Niall Anthony Gormley , Wouter Meuleman , Jacqueline Weir , Avgousta Ioannou , Gareth Jenkins , Rosamond Jackson , Natalie Morrell , Dmitry K. Pokholok , Steven J. Norberg , Molly He , Amirali Kia , Igor Goryshin , Rigo Pantoja
摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.
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公开(公告)号：US20130035480A1
公开(公告)日：2013-02-07
申请号：US13565400
申请日：2012-08-02
申请人： Frank J. Steemers , Kevin Gunderson , Kerri York
发明人： Frank J. Steemers , Kevin Gunderson , Kerri York
IPC分类号： C07H1/06 , C07D401/14 , C07D235/02
CPC分类号： C07H1/06 , C07D495/04 , C07H1/00 , C07H21/00 , C12N15/1003 , C12Q1/6811
摘要： Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.
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公开(公告)号：US09365897B2
公开(公告)日：2016-06-14
申请号：US13984005
申请日：2011-02-08
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q2521/301 , C12Q2521/319 , C12Q2537/159 , C12Q2537/162
摘要： Methods for the selective enrichment of nucleic acids.
摘要翻译： 选择性富集核酸的方法。
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公开(公告)号：US09074251B2
公开(公告)日：2015-07-07
申请号：US13080345
申请日：2011-04-05
申请人： Frank J. Steemers , Kevin Gunderson , Thomas Royce , Natasha Pignatelli , Igor Yu Goryshin , Nicholas Caruccio
发明人： Frank J. Steemers , Kevin Gunderson , Thomas Royce , Natasha Pignatelli , Igor Yu Goryshin , Nicholas Caruccio
IPC分类号： C12Q1/68
CPC分类号： C12N15/1082 , C12Q1/6869 , C12Q1/6874 , C12Q2521/319 , C12Q2521/507 , C12Q2525/155 , C12Q2525/161 , C12Q2525/185 , C12Q2525/191 , C12Q2525/197 , C12Q2525/313 , C12Q2535/122 , C12Q2565/514 , C12Q2521/301 , C12Q2521/327
摘要： Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target nucleic acids.
摘要翻译： 具有编码标签的人工转座子序列和含有该序列的靶核酸。 制备人工转座子和使用其性质分析靶核酸的方法。
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公开(公告)号：US20120208724A1
公开(公告)日：2012-08-16
申请号：US13080345
申请日：2011-04-05
申请人： Frank J. Steemers , Kevin Gunderson , Thomas Royce , Natasha Pignatelli , Igor Yu Goryshin , Nicholas Caruccio
发明人： Frank J. Steemers , Kevin Gunderson , Thomas Royce , Natasha Pignatelli , Igor Yu Goryshin , Nicholas Caruccio
CPC分类号： C12N15/1082 , C12Q1/6869 , C12Q1/6874 , C12Q2521/319 , C12Q2521/507 , C12Q2525/155 , C12Q2525/161 , C12Q2525/185 , C12Q2525/191 , C12Q2525/197 , C12Q2525/313 , C12Q2535/122 , C12Q2565/514 , C12Q2521/301 , C12Q2521/327
摘要： Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target nucleic acids.
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公开(公告)号：US20120208705A1
公开(公告)日：2012-08-16
申请号：US13025022
申请日：2011-02-10
CPC分类号： C12N15/1093 , C12N15/1065 , C12Q2563/179
摘要： Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target nucleic acids.
摘要翻译： 具有编码标签的人工转座子序列和含有该序列的靶核酸。 制备人工转座子和使用其性质分析靶核酸的方法。
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公开(公告)号：US08829171B2
公开(公告)日：2014-09-09
申请号：US13025022
申请日：2011-02-10
CPC分类号： C12N15/1093 , C12N15/1065 , C12Q2563/179
摘要： Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target nucleic acids.
摘要翻译： 具有编码标签的人工转座子序列和含有该序列的靶核酸。 制备人工转座子和使用其性质分析靶核酸的方法。
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公开(公告)号：US20100028923A1
公开(公告)日：2010-02-04
申请号：US11820882
申请日：2007-06-21
摘要： The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements reacts in a different manner with each of said one or more species of liquid analytes of interest to produce a detectable agent of each analyte of interest, whereby said detectable agent is analyzed and the information is processed for data acquisition and interpretation. In certain preferred embodiments, the detectable agent and/or change is detected directly, while in certain other preferred embodiments, the detectable agent and/or change is detected with the help of a transducing agent capable of relaying information about each detectable agent generated for each of said species of liquid analyte of interest, whereby said information is processed for data acquisition and interpretation. The present invention also provides method for the analysis of analytes comprising contacting one or more analytes with the inventive system described above.
摘要翻译： 本发明提供了一种利用交叉反应识别元件的新型交叉反应传感器系统。 在本发明的系统中，所述一个或多个交叉反应性识别元件中的每一个能够与多于一种的感兴趣的液体分析物相互作用，由此所述一个或多个交叉反应性识别元件中的每一个以不同的方式与每个 的所述一种或多种感兴趣的液体分析物种类以产生感兴趣的每种分析物的可检测试剂，由此分析所述可检测试剂，并且对所述信息进行处理以进行数据采集和解释。 在某些优选的实施方案中，直接检测可检测的试剂和/或变化，而在某些其它优选的实施方案中，可检测的试剂和/或变化是借助于能够中继关于每个可产生的每种可检测试剂的信息的转导剂 的所述物质的感兴趣的液体分析物，由此所述信息被处理用于数据采集和解释。 本发明还提供了用于分析分析物的方法，包括使一种或多种分析物与上述本发明的系统接触。
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公开(公告)号：US07250267B2
公开(公告)日：2007-07-31
申请号：US10221815
申请日：2001-03-14
摘要： The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements reacts in a different manner with each of said one or more species of liquid analytes of interest to produce a detectable agent of each analyte of interest, whereby said detectable agent is analyzed and the information is processed for data acquisition and interpretation. In certain preferred embodiments, the detectable agent and/or change is detected directly, while in certain other preferred embodiments, the detectable agent and/or change is detected with the help of a transducing agent capable of relaying information about each detectable agent generated for each of said species of liquid analyte of interest, whereby said information is processed for data acquisition and interpretation. The present invention also provides method for the analysis of analytes comprising contacting one or more analytes with the inventive system described above.
摘要翻译： 本发明提供了一种利用交叉反应识别元件的新型交叉反应传感器系统。 在本发明的系统中，所述一个或多个交叉反应性识别元件中的每一个能够与多于一种的感兴趣的液体分析物相互作用，由此所述一个或多个交叉反应性识别元件中的每一个以不同的方式与每个 的所述一种或多种感兴趣的液体分析物种类以产生感兴趣的每种分析物的可检测试剂，由此分析所述可检测试剂，并且对所述信息进行处理以进行数据采集和解释。 在某些优选的实施方案中，直接检测可检测的试剂和/或变化，而在某些其它优选的实施方案中，可检测的试剂和/或变化是借助于能够中继关于每个可产生的每种可检测试剂的信息的转导剂 的所述物质的感兴趣的液体分析物，由此所述信息被处理用于数据采集和解释。 本发明还提供了用于分析分析物的方法，包括使一种或多种分析物与上述本发明的系统接触。
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