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公开(公告)号:US08541476B2
公开(公告)日:2013-09-24
申请号:US12677478
申请日:2008-09-12
IPC分类号: A61K31/10 , C07C315/00 , C40B30/06
CPC分类号: A61K31/12 , A61K31/10 , A61K31/275 , A61K31/662 , A61K41/0038
摘要: The present invention comprises compounds, compositions and methods of use for sensitizing cancer cells, tumors, neoplasms, and malignancies to the effects of ionizing radiation used in the treatment of cancer. The invention further comprises a method of identifying novel radiosensitizing compounds.
摘要翻译: 本发明包括用于对癌细胞,肿瘤,肿瘤和恶性肿瘤敏感的化合物,组合物和方法用于治疗癌症中使用的电离辐射的作用。 本发明还包括鉴定新的放射增敏化合物的方法。
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公开(公告)号:US20110190400A1
公开(公告)日:2011-08-04
申请号:US12677478
申请日:2008-09-12
IPC分类号: A61K31/10 , C07C317/14 , C40B30/06 , A61P35/00
CPC分类号: A61K31/12 , A61K31/10 , A61K31/275 , A61K31/662 , A61K41/0038
摘要: The present invention comprises compounds, compositions and methods of use for sensitizing cancer cells, tumors, neoplasms, and malignancies to the effects of ionizing radiation used in the treatment of cancer. The invention further comprises a method of identifying novel radiosensitizing compounds.
摘要翻译: 本发明包括用于对癌细胞,肿瘤,肿瘤和恶性肿瘤敏感的化合物,组合物和方法用于治疗癌症中使用的电离辐射的作用。 本发明还包括鉴定新的放射增敏化合物的方法。
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公开(公告)号:US20060258620A1
公开(公告)日:2006-11-16
申请号:US11378961
申请日:2006-03-16
申请人: Jeffrey Smith , Fumiko Axelrod , Steven Kridel , Daniel Romo , Vikram Purohit , Gil Ma
发明人: Jeffrey Smith , Fumiko Axelrod , Steven Kridel , Daniel Romo , Vikram Purohit , Gil Ma
IPC分类号: A61K31/695 , A61K31/337 , A61K31/365
CPC分类号: A61K31/336 , A61K31/335 , A61K31/337 , A61K31/365 , A61K31/40 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/585 , G01N33/5011 , G01N2333/91057
摘要: The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.
摘要翻译: 本发明的特征在于通过向受试者施用有效量的β-内酯来治疗受试者的癌症的方法。 本发明还具有通过向受试者施用有效量的脂肪酸合酶抑制剂来抑制受试者血管生成的方法。 这些方法可用于治疗各种癌症和其他疾病和病症。 本发明还涉及鉴定可用于本发明治疗肿瘤,抑制血管发生以及涉及病理性血管生成的疾病和病症的治疗的β-内酯和其它化合物的方法。 本发明还具有合成β-内酯并具有新型β-内酯化合物特征的方法。
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公开(公告)号:US20060171947A1
公开(公告)日:2006-08-03
申请号:US11343911
申请日:2006-01-30
申请人: Jeffrey Smith , Steven Kridel , Fumiko Axelrod
发明人: Jeffrey Smith , Steven Kridel , Fumiko Axelrod
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号: C12N9/6445 , C07K2319/00 , C12N9/48
摘要: Proteins specific for prostate epithelial cells, normal or neoplastic, are identified and used for diagnosis, development of antibodies, and for evaluating drugs that react with the neoplastic specific proteins. Affinity based probes are used that react specifically with the active site to provide a measure of the enzyme activity of the cells. Prostate epithelial neoplastic cells can be used in screening candidate drugs for their effect in changing the proteome profile as to the serine-threonine hydrolase enzymes, using the affinity based probes for determining the profile.
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公开(公告)号:US20050181989A9
公开(公告)日:2005-08-18
申请号:US10243613
申请日:2002-09-13
申请人: Jeffrey Smith , Emily Chen , Steven Kridel
发明人: Jeffrey Smith , Emily Chen , Steven Kridel
IPC分类号: A61K47/48 , A61K49/00 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/11 , C07K5/117 , C07K7/06 , C07K7/08 , C12Q1/37 , A61K38/16 , C07K14/00
CPC分类号: A61K49/0021 , A61K47/64 , A61K49/0056 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/0823 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/1024 , C07K7/06 , C07K7/08 , C12Q1/37
摘要: The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selective substrate polypeptides contain SEQ ID NOS:28-35, and MT1-MMP selective substrate polypeptide contain SEQ ID NOS:36-40. In addition, the invention provides a method of preferentially directing a moiety to a site of MMP-2 activity by administering to a subject an effective amount of an isolated MMP-2 selective substrate polypeptide containing SEQ ID NOS:45-47 linked to a moiety. Also provided is a method of preferentially directing a moiety to a site of MMP-9 activity by administering to a subject an effective amount of an isolated MMP-9 selective substrate polypeptide containing SEQ ID NO:44 linked to a moiety, and preferentially directing a moiety to a site of MT1-MMP activity by administering to a subject an effective amount of an isolated MT1-MMP selective substrate polypeptide containing SEQ ID NOS:36-40 linked to a moiety.
摘要翻译: 本发明提供分离的MMP-2,MMP-9和MT1-MMP选择性底物多肽或功能肽模拟物。 选择性底物多肽包含以下序列:MMP-2选择性底物多肽含有SEQ ID NO:1-27,含有SEQ ID NO:28-35的MMP-9选择性底物多肽,并且含有SEQ ID NOS的MT1-MMP选择性底物多肽 :36-40。 此外,本发明提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO:45-47的分离的MMP-2选择性底物多肽来优先将部分定向到MMP-2活性位点的方法 。 还提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO:44的分离的MMP-9选择性底物多肽,优先将一部分连接至部分MMP-9活性部位的方法, 通过向受试者施用有效量的与部分连接的含有SEQ ID NO:36-40的分离的MT1-MMP选择性底物多肽,从而部分到MT1-MMP活性的位点。
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