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1.发明申请MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S 审中-公开S IN S S S S S S S S S S S S S S S S S S S S S S公开(公告)号：US20090118274A1
公开(公告)日：2009-05-07
申请号：US12031579
申请日：2008-02-14
Applicant: Darin Allen , Michael K. Ameriks , Frank U. Axe , Matthew Burdett , Hui Cai , Ingrid Choong , James P. Edwards , Willard Lew , Steven P. Meduna
Inventor： Darin Allen , Michael K. Ameriks , Frank U. Axe , Matthew Burdett , Hui Cai , Ingrid Choong , James P. Edwards , Willard Lew , Steven P. Meduna
IPC: A61K31/5377 , C07D471/04 , A61K31/496 , A61K31/4375 , A61P29/00 , A61P25/00 , A61P35/00 , A61P1/00 , A61P37/00 , A61K31/4545 , C07D471/10
CPC classification number: C07D471/04
Abstract: Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
Abstract translation: 描述了单环氨基丙基四氢 - 吡唑并吡啶化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。
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公开(公告)号：US06951851B2
公开(公告)日：2005-10-04
申请号：US10402696
申请日：2003-03-28
Applicant: Hui Cai , James P. Edwards , Steven P. Meduna , Barbara A. Pio , Jianmei Wei
Inventor： Hui Cai , James P. Edwards , Steven P. Meduna , Barbara A. Pio , Jianmei Wei
IPC: A61K31/275 , A61K31/4155 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/06 , C07D413/14 , C07D471/04 , C07D471/14 , C07D519/00 , C07D487/04 , A61K31/53
CPC classification number: C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , C07D401/14 , C07D409/14 , C07D471/04 , C07D471/14
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
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公开(公告)号：US06635633B2
公开(公告)日：2003-10-21
申请号：US09927188
申请日：2001-08-10
Applicant: Hui Cai , James P. Edwards , Steven P. Meduna , Barbara A. Pio , Jianmei Wei
Inventor： Hui Cai , James P. Edwards , Steven P. Meduna , Barbara A. Pio , Jianmei Wei
IPC: C07D48704
CPC classification number: C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , C07D401/14 , C07D409/14 , C07D471/04 , C07D471/14
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
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4.发明申请BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S 审中-公开双螺旋氨基磷酸四氢吡喃 - 吡咯啉吡啶类调节剂公开(公告)号：US20080269241A1
公开(公告)日：2008-10-30
申请号：US12031597
申请日：2008-02-14
Applicant: Darin Allen , Michael K. Ameriks , Frank U. Axe , Matthew Burdett , Hui Cai , Ingrid Choong , James P. Edwards , Willard Lew , Steven P. Meduna
Inventor： Darin Allen , Michael K. Ameriks , Frank U. Axe , Matthew Burdett , Hui Cai , Ingrid Choong , James P. Edwards , Willard Lew , Steven P. Meduna
IPC: A61K31/497 , C07D471/04 , C07D221/20 , C07D401/14 , A61P17/06 , A61P37/06 , A61P21/00 , A61P9/10 , A61K31/438 , A61K31/437
CPC classification number: C07D471/04 , C07D519/00
Abstract: Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
Abstract translation: 描述了双环氨基丙基四氢 - 吡唑并吡啶化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。
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公开(公告)号：US07429591B2
公开(公告)日：2008-09-30
申请号：US11517518
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/497 , C07D403/12
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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Patent Agency Ranking
公开(公告)号：US07417046B2
公开(公告)日：2008-08-26
申请号：US11517145
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/497 , C07D401/14 , C07D413/14 , C07D403/14
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US07589202B2
公开(公告)日：2009-09-15
申请号：US11517062
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: C07D403/06
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
Abstract translation: 取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号：US20080300255A1
公开(公告)日：2008-12-04
申请号：US12220516
申请日：2008-07-24
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/497 , A61P37/00
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US20080293732A1
公开(公告)日：2008-11-27
申请号：US12220539
申请日：2008-07-24
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/496 , A61P37/00
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号：US07393850B2
公开(公告)日：2008-07-01
申请号：US11517212
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/4965 , C07D401/02 , C07D403/04
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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