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公开(公告)号：US20100172927A1
公开(公告)日：2010-07-08
申请号：US12442538
申请日：2007-10-03
Applicant: Mark Alderson , Rhea Coler , Yves Lobet , Jean-Francois L. Maisonneuve , Pascal Mettens , Peter Probst , Steven Reed
Inventor： Mark Alderson , Rhea Coler , Yves Lobet , Jean-Francois L. Maisonneuve , Pascal Mettens , Peter Probst , Steven Reed
IPC: A61K39/118 , A61P31/04 , A61P27/00 , C07K14/295
CPC classification number: A61K39/118 , A61K2039/53 , A61K2039/54 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577
Abstract: Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.
Abstract translation: 用于治疗或预防眼沙眼衣原体感染的方法和组合物。 组合物包含一种或多种沙眼衣原体蛋白，其免疫原性片段或编码这种蛋白质或片段的多核苷酸。
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公开(公告)号：US08470338B2
公开(公告)日：2013-06-25
申请号：US11912730
申请日：2006-04-27
Applicant: Rhea Coler , Yves Lobet , Steven Reed
Inventor： Rhea Coler , Yves Lobet , Steven Reed
CPC classification number: A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35
Abstract: The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.
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公开(公告)号：US20090123491A1
公开(公告)日：2009-05-14
申请号：US11912730
申请日：2006-04-27
Applicant: Rhea Coler , Yves Lobet , Steven Reed
Inventor： Rhea Coler , Yves Lobet , Steven Reed
IPC: A61K39/04 , A61K31/7088 , A61P37/04
CPC classification number: A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35
Abstract: The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.
Abstract translation: 本发明涉及通过施用包含编码Mtb72f融合蛋白或Mtb72f融合蛋白或其免疫原性片段的核酸的药物组合物，例如与佐剂一起施用来防止活性和潜伏性结核分枝杆菌感染的再活化的方法 。 Mtb72f核酸或融合蛋白可以与一种或多种对结核分枝杆菌感染有效的化学治疗剂一起施用。 所述方法还提供了缩短化疗方案针对结核分枝杆菌感染的时间过程。
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4.发明申请公开(公告)号：US20080033398A1
公开(公告)日：2008-02-07
申请号：US11617606
申请日：2006-12-28
Applicant: Steven Reed , Rhea Coler
Inventor： Steven Reed , Rhea Coler
CPC classification number: A61N1/325 , A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/205 , A61N1/303
Abstract: A device and a method are provided to enhance an immune response to a vaccine or immunogen by electrical stimulation of a biological interface in conjunction with administration of the vaccine or immunogen.
Abstract translation: 提供了一种装置和方法，以通过与疫苗或免疫原的施用联合生物界面的电刺激来增强对疫苗或免疫原的免疫应答。
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公开(公告)号：US08110200B2
公开(公告)日：2012-02-07
申请号：US12698893
申请日：2010-02-02
Applicant: Yasir Skeiky , Jeff Guderian , Steven Reed
Inventor： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC classification number: C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
Abstract translation: 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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Patent Agency Ranking
公开(公告)号：US08071747B2
公开(公告)日：2011-12-06
申请号：US12490272
申请日：2009-06-23
Applicant: Yasir Skeiky , Steven Reed , Mark Alderson
Inventor： Yasir Skeiky , Steven Reed , Mark Alderson
CPC classification number: C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US08067016B2
公开(公告)日：2011-11-29
申请号：US12490984
申请日：2009-06-24
Applicant: Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
Inventor： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
CPC classification number: A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
Abstract translation: 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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公开(公告)号：US20100183677A1
公开(公告)日：2010-07-22
申请号：US12698976
申请日：2010-02-02
Applicant: Yasir Skeiky , Jeff Guderian , Steven Reed
Inventor： Yasir Skeiky , Jeff Guderian , Steven Reed
IPC: A61K39/04 , A61K31/7088 , A61P31/06 , A61K45/00
CPC classification number: C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
Abstract translation: 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US07691993B2
公开(公告)日：2010-04-06
申请号：US11982179
申请日：2007-10-31
Applicant: Yasir Skeiky , Jeff Guderian , Steven Reed
Inventor： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC classification number: C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US07311922B1
公开(公告)日：2007-12-25
申请号：US09688672
申请日：2000-10-10
Applicant: Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
Inventor： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
IPC: A61K39/08 , A61K39/02 , A61K39/40 , A61K39/395
CPC classification number: A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
Abstract translation: 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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