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公开(公告)号:US20050148572A1
公开(公告)日:2005-07-07
申请号:US10499177
申请日:2002-12-20
申请人: Alan Borthwick , Richard Hatley , Deirdre Hickey , John Liddle , David Livermore , Andrew Mason , Neil Miller , Fabrizio Nerozzi , Steven Sollis , Anna Szardenings , Paul Wyatt
发明人: Alan Borthwick , Richard Hatley , Deirdre Hickey , John Liddle , David Livermore , Andrew Mason , Neil Miller , Fabrizio Nerozzi , Steven Sollis , Anna Szardenings , Paul Wyatt
IPC分类号: C07D241/04 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K38/00 , A61P15/06 , A61P43/00 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D417/12 , C07D491/113 , C07K5/06 , C07K5/065 , C07D413/02 , C07D43/02
CPC分类号: C07D241/08 , A61K38/00 , C07D401/10 , C07D403/06 , C07D413/10 , C07D417/06 , C07K5/06078 , C07K5/06191
摘要: A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a mammal in need thereof of an effective amount of a compound of the formula (I) and/or a physiologically acceptable derivative thereof, wherein the substituents have the meaning given in the description. Disclosed are also novel compounds of formula (I) and processes for their preparation.
摘要翻译: 一种治疗或预防通过催产素作用介导的疾病或病症的方法,其包括向有需要的哺乳动物施用有效量的式(I)化合物和/或其生理上可接受的衍生物,其中所述取代基具有 说明中给出的含义。 公开了式(I)的新化合物及其制备方法。
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公开(公告)号:US20070208031A1
公开(公告)日:2007-09-06
申请号:US11630097
申请日:2005-06-21
申请人: Alan Borthwick , Steven Sollis
发明人: Alan Borthwick , Steven Sollis
IPC分类号: A61K31/496 , C07D403/02
CPC分类号: C07D403/06
摘要: Compounds of formula (IA) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is 1-methyl-indazol-5-yl, R4 represents methyl and R5 represents hydrogen or methyl, and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.
摘要翻译: 其中R 1是2-二氢茚基,R 2的式(IA)化合物是1-甲基丙基,R 3是1-甲基 - 吲唑 -5-基,R 4代表甲基,R 5表示氢或甲基,并且其药学上可接受的衍生物被描述,其制备方法,含有它们的药物组合物 及其在医药中的用途,特别是用作催产素拮抗剂。
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3.
公开(公告)号:US20070185162A1
公开(公告)日:2007-08-09
申请号:US11630100
申请日:2005-06-21
申请人: Alan Borthwick , Deidre Mary Hickey , John Liddle , Andrew Mason , Derek Pollard , Steven Sollis
发明人: Alan Borthwick , Deidre Mary Hickey , John Liddle , Andrew Mason , Derek Pollard , Steven Sollis
IPC分类号: A61K31/445 , C07D241/04
CPC分类号: C07D401/06 , C07D403/06 , C07D413/06
摘要: Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-ethylpropyl, R3 is a heterocyclic group optionally substituted by one or more C1-6 alkyl groups, R4 represents methyl and R5 represents hydrogen or methyl and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.
摘要翻译: 其中R 1是2-二氢茚基,R 2的式(I)化合物是1-乙基丙基,R 3是任选取代的杂环基 通过一个或多个C 1-6烷基,R 4代表甲基,R 5表示氢或甲基,其药学上可接受的衍生物被描述 ,其制备方法,含有它们的药物组合物及其在医药中的用途,特别是其作为催产素拮抗剂的用途。
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