Method for minimizing disturbances in circadian rhythms of bodily
performance and function
    3.
    发明授权
    Method for minimizing disturbances in circadian rhythms of bodily performance and function 失效
    最小化身体表现和功能的昼夜节奏紊乱的方法

    公开(公告)号:US4600723A

    公开(公告)日:1986-07-15

    申请号:US611677

    申请日:1984-05-18

    IPC分类号: A61K31/40 C07D209/16

    CPC分类号: C07D209/16 A61K31/40

    摘要: Disturbances in circadian rhythms of bodily performance and function, as may occur for example in transfer of work patterns from day to night-shift, or rapid crossing of several time zones in an aircraft ("jet lag") are treated by administration of melatonin. Alleviation or prevention of ill effects associated with disturbance of circadian rhythms is achieved by administration of melatonin in specified ways which are varied to suit particular needs and circumstances.

    摘要翻译: 通过施用褪黑激素来治疗身体表现和功能的昼夜节奏紊乱,例如在工作模式从白天到夜班或飞行器中几个时区的快速穿越中可能发生的情况(“时差”)。 减轻或预防与昼夜节律紊乱相关的不良影响是通过以特定的方式施用褪黑激素来实现的,这些方式根据特定需要和情况而变化。

    Process to produce tetrabromobisphenol with the reduced formation of
alkyl bromide by-products
    5.
    发明授权
    Process to produce tetrabromobisphenol with the reduced formation of alkyl bromide by-products 失效
    生产四溴双酚同时还原形成烷基溴副产物的方法

    公开(公告)号:US5475153A

    公开(公告)日:1995-12-12

    申请号:US368351

    申请日:1995-01-04

    申请人: Stuart Armstrong

    发明人: Stuart Armstrong

    IPC分类号: C07C37/62 C07C39/367

    CPC分类号: C07C37/62

    摘要: A process for the preparation of 4,4'-isopropylidene bis(2,6-dibromophenol), also known as tetrabrombisphenol A, that dramatically reduces the formation of alkyl bromide by-products. Bisphenol A is brominated with a C.sub.3 to C.sub.5 n-alcohol in a water mixture to suppress the formation of alkyl bromides. The bisphenol A is brominated between 15.degree. C. and 25.degree. C. and then heated at a 55.degree. C. to 70.degree. C. to insure bromination is complete. The tetrabrombisphenol A is then filtered from the reaction mixture and dried. Tetrabromobisphenol A produced from this process typically has a melting point of 180.degree. C. or higher, and is typically greater than 98% pure. Hydrogen peroxide is optionally combined with the reactants to reduce the amount of added bromine necessary for the bromination of the tetrabromobisphenol A.

    摘要翻译: 制备4,4'-异亚丙基双(2,6-二溴苯酚)(也称为四溴双酚A)的方法,其显着降低了烷基溴副产物的形成。 双酚A在水混合物中用C 3至C 5正构醇溴化以抑制烷基溴的形成。 双酚A在15℃和25℃之间溴化,然后在55℃加热至70℃以确保溴化完成。 然后将四溴双酚A从反应混合物中过滤并干燥。 由该方法生产的四溴双酚A通常具有180℃或更高的熔点,并且通常大于98%纯度。 任选地将过氧化氢与反应物组合以减少溴化四溴双酚A所需的溴的量。