公开(公告)号：US20050187268A1

公开(公告)日：2005-08-25

申请号：US11065270

申请日：2005-02-23

申请人： Moritz von Rechenberg ,  John Peltier ,  Sudhir Sahasrabudhe ,  Srdjan Askovic ,  Robert Selliah ,  Thomas Zarembinski

发明人： Moritz von Rechenberg ,  John Peltier ,  Sudhir Sahasrabudhe ,  Srdjan Askovic ,  Robert Selliah ,  Thomas Zarembinski

IPC分类号： A61K31/00 ,  A61K31/352 ,  A61K31/433 ,  A61K31/4409

CPC分类号： A61K31/00 ,  A61K31/352 ,  A61K31/433 ,  A61K31/4409

摘要： The present invention provides compositions and methods for modulating smooth muscle cells. The present invention also provides methods of identifying small molecule candidate therapeutic agents for modulating smooth muscle.

摘要翻译： 本发明提供调节平滑肌细胞的组合物和方法。 本发明还提供鉴定用于调节平滑肌的小分子候选治疗剂的方法。

公开(公告)号：US20060211683A1

公开(公告)日：2006-09-21

申请号：US11340430

申请日：2006-01-25

申请人： Robert Selliah ,  Longwu Qi ,  Paul Robbins ,  Sudhir Sahasrabudhe ,  Brent Stockwell ,  Raj Venkat

发明人： Robert Selliah ,  Longwu Qi ,  Paul Robbins ,  Sudhir Sahasrabudhe ,  Brent Stockwell ,  Raj Venkat

IPC分类号： A61K31/551 ,  A61K31/517 ,  C07D403/02

CPC分类号： A61K31/495 ,  C07D239/90 ,  C07D405/12 ,  C07D409/12 ,  G01N33/5011 ,  G01N33/6872

摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.