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公开(公告)号：US20060211683A1
公开(公告)日：2006-09-21
申请号：US11340430
申请日：2006-01-25
申请人： Robert Selliah , Longwu Qi , Paul Robbins , Sudhir Sahasrabudhe , Brent Stockwell , Raj Venkat
发明人： Robert Selliah , Longwu Qi , Paul Robbins , Sudhir Sahasrabudhe , Brent Stockwell , Raj Venkat
IPC分类号： A61K31/551 , A61K31/517 , C07D403/02
CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872
摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
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公开(公告)号：US20070027164A1
公开(公告)日：2007-02-01
申请号：US11349653
申请日：2006-02-07
IPC分类号： A61K31/496 , A61K31/4709 , A61K31/452 , A61K31/4015 , A61K31/365
CPC分类号： A61K31/365 , A61K31/381 , A61K31/404 , A61K31/472 , A61K31/4725 , A61K31/517 , A61K31/519
摘要： The present invention relates to compounds effective in preventing neuronal cell death, which may be used in the treatment of neurodegenerative diseases. It is based, at least in part, on the discovery that particular compounds were effective in preventing neuronal death in model systems of Huntington's Disease.
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公开(公告)号：US20070149543A1
公开(公告)日：2007-06-28
申请号：US11612286
申请日：2006-12-18
IPC分类号： A61K31/496 , A61K31/4709 , A61K31/452 , A61K31/4025
CPC分类号： A61K31/4025 , A61K31/452 , A61K31/4709 , A61K31/496
摘要： The present invention relates to compounds effective in preventing neuronal cell death, which may be used in the treatment of neurodegenerative diseases. It is based, at least in part, on the discovery that particular compounds were effective in preventing neuronal death in model systems of Huntington's Disease.
摘要翻译： 本发明涉及有效预防神经元细胞死亡的化合物，其可用于治疗神经变性疾病。 至少部分是基于发现特定化合物有效预防亨廷顿氏症模型系统中的神经元死亡。
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公开(公告)号：US20070161644A1
公开(公告)日：2007-07-12
申请号：US11492546
申请日：2006-07-24
申请人： Brent Stockwell
发明人： Brent Stockwell
IPC分类号： A61K31/517 , C07D403/02
CPC分类号： C07D405/12 , C07D239/91 , C07D403/06
摘要： The present invention relates to erastin analogs, particularly compounds of formulae VI, VIa, VII, and VIIa, as well as compounds 19, 20, and 20. The invention also relates to pharmaceutical compositions containing such analogs and to methods of treating a condition in a mammal with such analogs and compositions.
摘要翻译： 本发明涉及伊拉斯汀类似物，特别是式VI，VIa，VII和VIIa的化合物，以及化合物19,20和20.本发明还涉及含有此类类似物的药物组合物和治疗病症的方法 具有这种类似物和组合物的哺乳动物。
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公开(公告)号：US20070099906A1
公开(公告)日：2007-05-03
申请号：US11635704
申请日：2006-12-07
申请人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
发明人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
IPC分类号： A61K31/5415 , A61K31/495 , A61K31/155
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
摘要翻译： 本发明的特征在于一种用于治疗患有癌症或其他肿瘤的患者的方法，所述方法通过以足以治疗患者的量彼此同时或相互给药14天内向患者施用两种化合物。
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公开(公告)号：US20070099905A1
公开(公告)日：2007-05-03
申请号：US11585486
申请日：2006-10-24
申请人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell , Debra Gaw , M. Nichols , Margaret Lee
发明人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell , Debra Gaw , M. Nichols , Margaret Lee
IPC分类号： A61K31/551 , A61K31/506 , A61K31/495 , A61K31/4439 , A61K31/4433 , A61K31/381 , A61K31/34
CPC分类号： A61K45/06 , A61K31/496 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
摘要翻译： 本发明的特征在于一种用于治疗患有癌症或其他肿瘤的患者的方法，所述方法通过以足以治疗患者的量彼此同时或相互给药14天内向患者施用两种化合物。
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公开(公告)号：US20070078144A1
公开(公告)日：2007-04-05
申请号：US11498110
申请日：2006-08-02
IPC分类号： A61K31/496 , A61K31/4709 , A61K31/452 , A61K31/4025
CPC分类号： A61K31/4025 , A61K31/452 , A61K31/4709 , A61K31/496
摘要： The present invention relates to compounds effective in preventing neuronal cell death, which may be used in the treatment of neurodegenerative diseases. It is based, at least in part, on the discovery that particular compounds were effective in preventing neuronal death in model systems of Huntington's Disease.
摘要翻译： 本发明涉及有效预防神经元细胞死亡的化合物，其可用于治疗神经变性疾病。 至少部分是基于发现特定化合物有效预防亨廷顿氏症模型系统中的神经元死亡。
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公开(公告)号：US20050192274A1
公开(公告)日：2005-09-01
申请号：US11024303
申请日：2004-12-28
申请人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
发明人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
IPC分类号： A61K9/72 , A61K31/155 , A61K31/54 , A61K31/5415 , A61K45/06 , A61P35/00 , A61P43/00 , A61K31/498 , A61K31/538
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
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9.发明申请Identification of genotype-selective agents for treating Huntington's disease 审中-公开鉴定用于治疗亨廷顿舞蹈病的基因型选择剂公开(公告)号：US20050032124A1
公开(公告)日：2005-02-10
申请号：US10767591
申请日：2004-01-29
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5014 , G01N33/5058 , G01N2800/2835
摘要： The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that selectively suppress huntingtin-induced toxicity to engineered neuronal cells.
摘要翻译： 本发明涉及识别基因型选择性试剂的方法。 在某些实施方案中，本发明涉及选择性抑制亨特啶诱导的工程化神经元细胞毒性的试剂。
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