公开(公告)号：US20140148455A1

公开(公告)日：2014-05-29

申请号：US13812597

申请日：2011-07-28

Applicant: Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

Inventor： Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

IPC: A61K31/5377 ,  A61K31/165

CPC classification number: A61K31/5377 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/165 ,  A61K31/5575 ,  A61K47/02 ,  A61K47/12 ,  A61K2300/00

Abstract: The present invention is directed to preservative-free solutions of bimatoprost and timolol for lowering intra-ocular pressure and treatment of glaucoma.

公开(公告)号：US20130245124A1

公开(公告)日：2013-09-19

申请号：US13812594

申请日：2011-07-28

Applicant: Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

Inventor： Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

IPC: A61K9/08 ,  A61K31/5575

CPC classification number: A61K31/5575 ,  A61K9/0048 ,  A61K9/08

Abstract: The present invention is directed to preservative-free solutions of bimatoprost for lowering intra-ocular pressure and treatment of glaucoma.

Abstract translation: 本发明涉及用于降低眼内压和治疗青光眼的比马前列素的无防腐剂溶液。

公开(公告)号：US20130005665A1

公开(公告)日：2013-01-03

申请号：US13537197

申请日：2012-06-29

Applicant: Anuradha V. Gore ,  Kevin S. Warner ,  Chetan P. Pujara ,  Richard S. Graham ,  Ajay Parashar ,  Mu-Lan Lee ,  Robert S. Jordan ,  Sukhon Likitlersuang

Inventor： Anuradha V. Gore ,  Kevin S. Warner ,  Chetan P. Pujara ,  Richard S. Graham ,  Ajay Parashar ,  Mu-Lan Lee ,  Robert S. Jordan ,  Sukhon Likitlersuang

IPC: A61K38/13 ,  A61K31/5685 ,  A61P27/06 ,  A61K31/165 ,  A61P27/02 ,  A61K31/4164 ,  A61K31/4025

CPC classification number: A61K31/417 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/165 ,  A61K31/4025 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/5575 ,  A61K31/568 ,  A61K31/5685 ,  A61K38/13 ,  A61K47/14

Abstract: Provided herein are compositions, which include an active pharmaceutical ingredient and macrogol 15 hydroxystearate, and methods for using the same for treating diseases or disorder.

Abstract translation: 本文提供了包含活性药物成分和聚乙二醇羟基硬脂酸酯的组合物及其用于治疗疾病或病症的方法。

公开(公告)号：US20080107719A1

公开(公告)日：2008-05-08

申请号：US11594517

申请日：2006-11-08

Applicant: Sukhon Likitlersuang ,  Chin-Ming Chang ,  James Chang ,  Orest Olejnik

Inventor： Sukhon Likitlersuang ,  Chin-Ming Chang ,  James Chang ,  Orest Olejnik

IPC: A61K9/70 ,  A61K31/13 ,  A61P25/28

CPC classification number: A61K9/7084 ,  A61K9/0009 ,  A61K47/08 ,  A61K47/16 ,  A61K47/26 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/327

Abstract: A transdermal drug delivery system includes a drug source, an adhesive for applying the system to a skin surface, a penetration enhancer for enhancing penetration of the drug into the skin surface, an energy source and a contact for conveying energy from said energy source through said adhesive and the penetrating enhancer.

Abstract translation: 透皮药物递送系统包括药物源，用于将系统施用于皮肤表面的粘合剂，用于增强药物渗入皮肤表面的渗透促进剂，能量源和用于将能量从所述能量源传递通过所述皮肤表面的接触件 粘合剂和渗透增强剂。

公开(公告)号：US10213431B2

公开(公告)日：2019-02-26

申请号：US13812599

申请日：2011-07-28

Applicant: Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

Inventor： Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

IPC: A61K31/498 ,  A61K31/5377 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02 ,  A61K47/12

Abstract: The present invention is directed to preservative-free solutions of brimonidine and timolol for lowering intra-ocular pressure and treatment of glaucoma.

公开(公告)号：US09078854B2

公开(公告)日：2015-07-14

申请号：US13812597

申请日：2011-07-28

Applicant: Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

Inventor： Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

IPC: A61K31/5575 ,  A61K31/5377 ,  A61K31/165 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02 ,  A61K47/12

CPC classification number: A61K31/5377 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/165 ,  A61K31/5575 ,  A61K47/02 ,  A61K47/12 ,  A61K2300/00

Abstract: The present invention is directed to preservative-free solutions of bimatoprost and timolol for lowering intra-ocular pressure and treatment of glaucoma.

Abstract translation: 本发明涉及用于降低眼内压和治疗青光眼的比马前列素和噻吗洛尔的无防腐剂溶液。

公开(公告)号：US20140148456A1

公开(公告)日：2014-05-29

申请号：US13812599

申请日：2011-07-28

Applicant: Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

Inventor： Sukhon Likitlersuang ,  Ajay Parashar ,  Chetan P. Pujara ,  William F. Kelly

IPC: A61K31/5377 ,  A61K31/498

CPC classification number: A61K31/5377 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/498 ,  A61K47/02 ,  A61K47/12 ,  A61K2300/00

Abstract: The present invention is directed to preservative-free solutions of brimonidine and timolol for lowering intra-ocular pressure and treatment of glaucoma.

Abstract translation: 本发明涉及溴莫尼定和噻吗洛尔用于降低眼内压和治疗青光眼的无防腐剂溶液。

公开(公告)号：US20130029919A1

公开(公告)日：2013-01-31

申请号：US13557611

申请日：2012-07-25

Applicant: Anuradha V. GORE ,  Sai M. SHANKAR ,  Sukhon LIKITLERSUANG ,  Chetan P. PUJARA ,  Sesha NEERVANNAN

Inventor： Anuradha V. GORE ,  Sai M. SHANKAR ,  Sukhon LIKITLERSUANG ,  Chetan P. PUJARA ,  Sesha NEERVANNAN

IPC: A61K31/4025 ,  A61P27/02 ,  A61K31/568 ,  A61K31/4164 ,  A61K38/13

Abstract: Ophthalmic products and related methods are described herein. These methods include a stabilizing composition comprising a therapeutically active agent which is separated from a liquid vehicle composition by a barrier. The barrier may be removed to allow the two compositions to mix to provide an ophthalmically acceptable liquid comprising the therapeutically active agent.

Abstract translation: 本文描述了眼科产品和相关方法。 这些方法包括稳定组合物，其包含通过屏障与液体载体组合物分离的治疗活性剂。 可以除去阻挡层以允许两种组合物混合以提供包含治疗活性剂的眼科可接受的液体。

公开(公告)号：US20110178147A1

公开(公告)日：2011-07-21

申请号：US12907719

申请日：2010-10-19

Applicant: Sukhon Likitlersuang ,  Ajay P. Parashar ,  Chetan Pujara

Inventor： Sukhon Likitlersuang ,  Ajay P. Parashar ,  Chetan Pujara

IPC: A61K31/417 ,  A61P27/02

CPC classification number: A61K31/417 ,  A61K9/0048

Abstract: The disclosure provides a composition for controlling pupil dilation comprising about 0.001% to about 1.0% by weight of an alpha-adrenergic receptor antagonist selected from phentolamine, phentolamine mesylate, or a phentolamine salt; and at least one excipient selected from the group consisting of a buffer, tonicity agent, preservative, antioxidant, surfactant, solubilizer, cosolvent, and a combination thereof. A method of controlling pupil dilation in a subject in need thereof, comprising administering a therapeutically effective amount of the composition is also provided.

Abstract translation: 本公开提供了一种用于控制瞳孔扩张的组合物，其包含约0.001重量％至约1.0重量％的选自酚妥拉明，甲磺酸酚妥拉明或酚妥拉明盐的α-肾上腺素能受体拮抗剂; 和至少一种选自缓冲剂，张度剂，防腐剂，抗氧化剂，表面活性剂，增溶剂，助溶剂及其组合的赋形剂。 还提供了一种控制有需要的受试者的瞳孔扩张的方法，包括施用治疗有效量的组合物。