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公开(公告)号:US07435739B2
公开(公告)日:2008-10-14
申请号:US10989842
申请日:2004-11-16
IPC分类号: C07D487/04 , A61K31/519 , A61K31/664 , C07F9/24 , A61P35/04
CPC分类号: C07D487/04
摘要: The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein X, L, R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
摘要翻译: 本发明涉及式1化合物或其药学上可接受的盐,前药或水合物,其中X,L,R 1,R 2,R 3, < / SUP>和R 4>如本文所定义。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物治疗哺乳动物中过度增殖性疾病的方法。
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公开(公告)号:US07276602B2
公开(公告)日:2007-10-02
申请号:US10626406
申请日:2003-07-24
IPC分类号: C07D412/02 , C07D417/12
CPC分类号: C07D417/12
摘要: The invention relates to compounds of the formula 1 or pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof, wherein wherein X, R1, and R2 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
摘要翻译: 本发明涉及式1的化合物或其药学上可接受的盐,前药,溶剂化物或水合物,其中X,R 1和R 2如本文所定义。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物治疗哺乳动物中过度增殖性疾病的方法。
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公开(公告)号:US20100234435A1
公开(公告)日:2010-09-16
申请号:US12779379
申请日:2010-05-13
申请人: Samit K. Bhattacharya , Matthew F. Brown , Peter H. Dorff , Susan D. LaGreca , John W. Mickelson , Joseph A. Cornicelli , David L. Brown , Jennings Rex , John K. Walker , Rita Huff , Joseph W. Strohbach , Robert J. Maguire
发明人: Samit K. Bhattacharya , Matthew F. Brown , Peter H. Dorff , Susan D. LaGreca , John W. Mickelson , Joseph A. Cornicelli , David L. Brown , Jennings Rex , John K. Walker , Rita Huff , Joseph W. Strohbach , Robert J. Maguire
IPC分类号: A61K31/4245 , C07D271/06 , A61P19/02 , C07D405/14 , C07D401/04
CPC分类号: C07D271/06
摘要: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐,前药,溶剂合物或水合物。 本发明还涉及使用这些化合物治疗哺乳动物,特别是人类的过度增殖性疾病和自身免疫性疾病的方法,以及含有这些化合物的药物组合物。
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公开(公告)号:US20090227641A1
公开(公告)日:2009-09-10
申请号:US12266997
申请日:2008-11-07
申请人: Samit K. Bhattacharya , Matthew F. Brown , Peter H. Dorff , Susan D. LaGreca , John W. Mickelson , Joseph A. Cornicelli , David L. Brown , Rex Jennings , John K. Walker , Rita Huff , Joseph W. Strohbach , Robert J. Maguire
发明人: Samit K. Bhattacharya , Matthew F. Brown , Peter H. Dorff , Susan D. LaGreca , John W. Mickelson , Joseph A. Cornicelli , David L. Brown , Rex Jennings , John K. Walker , Rita Huff , Joseph W. Strohbach , Robert J. Maguire
IPC分类号: A61K31/4245 , C07D271/06 , A61P19/02 , A61P35/00
CPC分类号: C07D271/06
摘要: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐,前药,溶剂合物或水合物。 本发明还涉及使用这些化合物治疗哺乳动物,特别是人类的过度增殖性疾病和自身免疫性疾病的方法,以及含有这些化合物的药物组合物。
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