公开(公告)号：US08475808B2

公开(公告)日：2013-07-02

申请号：US10557427

申请日：2004-05-21

申请人： William Andrews ,  David Chien ,  Qui-Lim Choo ,  Stephen Coates ,  Doris Coit ,  Charles Harrington ,  Susan Hilt ,  Michael Houghton ,  Angelica Medina-Selby ,  Sergio Pichuantes ,  Yiu-Lian Fong

发明人： William Andrews ,  David Chien ,  Qui-Lim Choo ,  Stephen Coates ,  Doris Coit ,  Charles Harrington ,  Susan Hilt ,  Michael Houghton ,  Angelica Medina-Selby ,  Sergio Pichuantes ,  Yiu-Lian Fong

IPC分类号： A61K39/12 ,  C12Q1/70 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/55566 ,  C07K2319/02 ,  C12N2770/24122 ,  C12N2770/24134 ,  G01N33/56983 ,  G01N33/6854 ,  G01N2333/18 ,  G01N2469/20 ,  Y02A50/394

摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.

摘要翻译： 描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。 包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。 还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

公开(公告)号：US20070092538A1

公开(公告)日：2007-04-26

申请号：US10557427

申请日：2004-05-21

申请人： William Andrews ,  David Chien ,  Qui-Lim Choo ,  Stephen Coates ,  Doris Coit ,  Charles Harrington ,  Susan Hilt ,  Michael Houghton ,  Angelica Medina-Selby ,  Sergio Pichuantes

发明人： William Andrews ,  David Chien ,  Qui-Lim Choo ,  Stephen Coates ,  Doris Coit ,  Charles Harrington ,  Susan Hilt ,  Michael Houghton ,  Angelica Medina-Selby ,  Sergio Pichuantes

IPC分类号： A61K39/12 ,  C12Q1/70 ,  C12N15/86 ,  C07K14/18 ,  C12N5/08 ,  C12N5/06

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/55566 ,  C07K2319/02 ,  C12N2770/24122 ,  C12N2770/24134 ,  G01N33/56983 ,  G01N33/6854 ,  G01N2333/18 ,  G01N2469/20 ,  Y02A50/394

摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.

摘要翻译： 描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。 包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。 还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。