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公开(公告)号：US08475808B2
公开(公告)日：2013-07-02
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译： 描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。 包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。 还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。
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公开(公告)号：US20090258033A1
公开(公告)日：2009-10-15
申请号：US12454074
申请日：2009-05-12
IPC分类号： A61K39/29
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： HCV E1E2 compositions comprising E1E2 antigens, submicron oil-in-water emulsions and/or immunostimulatory nucleic acid sequences are described. The compositions can be used in methods of stimulating an immune response in a vertebrate subject.
摘要翻译： 描述了包含E1E2抗原的HCV E1E2组合物，亚微米水包油乳剂和/或免疫刺激性核酸序列。 该组合物可用于刺激脊椎动物受试者的免疫应答的方法。
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3.发明申请公开(公告)号：US20060008798A1
公开(公告)日：2006-01-12
申请号：US11148012
申请日：2005-06-07
申请人： David Chien , Yiu-Lian Fong , Azita Tabrizi , Heather Todd , Mark Van Cleve
发明人： David Chien , Yiu-Lian Fong , Azita Tabrizi , Heather Todd , Mark Van Cleve
CPC分类号： C07K16/082 , C07K2317/20 , C07K2317/33 , G01N33/5764
摘要： Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies directed against HBV surface antigens (HBsAg) with mutations in the “a” determinant region of HBsAg.
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4.发明授权公开(公告)号：US07563873B2
公开(公告)日：2009-07-21
申请号：US11148012
申请日：2005-06-07
IPC分类号： C12P21/08
CPC分类号： C07K16/082 , C07K2317/20 , C07K2317/33 , G01N33/5764
摘要： Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies directed against HBV surface antigens (HBsAg) with mutations in the “a” determinant region of HBsAg.
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5.发明申请Compositions and Methods for Preparation of Nucleic Acids from Microbial Samples 审中-公开从微生物样品制备核酸的组合物和方法公开(公告)号：US20080193912A1
公开(公告)日：2008-08-14
申请号：US11659255
申请日：2005-08-03
申请人： Yiu-Lian Fong , Azita Tabrizi
发明人： Yiu-Lian Fong , Azita Tabrizi
摘要： Methods and compositions for releasing the nucleic acids from a variety of different types of microorganisms are provided. The method relies on a simplified lysis procedure that can be applied to many types of bacteria and fungal cells and is readily automated for high throughput screening methods. The method utilizes a high concentration of a chelating agent and a mixture of lysing enzymes to accomplish the disruption of microbial cell walls and allow the release of the nucleic acid.
摘要翻译： 提供了用于从各种不同类型的微生物释放核酸的方法和组合物。 该方法依赖于可以应用于许多类型的细菌和真菌细胞的简化的裂解方法，并且容易地自动化用于高通量筛选方法。 该方法利用高浓度的螯合剂和裂解酶的混合物来完成微生物细胞壁的破坏并允许释放核酸。
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公开(公告)号：US20050255124A1
公开(公告)日：2005-11-17
申请号：US11154324
申请日：2005-06-16
申请人： Michael Hougton , Stephen Coates , Derek O'Hagan , Yiu-Lian Fong
发明人： Michael Hougton , Stephen Coates , Derek O'Hagan , Yiu-Lian Fong
IPC分类号： A61K39/29 , A01N43/04 , A61K9/107 , A61K31/70 , A61K39/12 , A61K39/39 , A61K45/00 , A61K47/00 , A61K47/06 , A61K47/22 , A61K47/34 , A61K48/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P37/04 , C07K14/18 , C12N15/09 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： HCV E1E2 compositions comprising E1E2 antigens, submicron oil-in-water emulsions and/or immunostimulatory nucleic acid sequences are described. The compositions can be used in methods of stimulating an immune response in a vertebrate subject.
摘要翻译： 描述了包含E1E2抗原的HCV E1E2组合物，亚微米水包油乳剂和/或免疫刺激性核酸序列。 该组合物可用于刺激脊椎动物受试者的免疫应答的方法。
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7.发明授权Rabbit monoclonal antibodies to hepatitis B surface antigens and methods of using the same 有权兔单克隆抗体对乙型肝炎表面抗原及其使用方法公开(公告)号：US08173375B2
公开(公告)日：2012-05-08
申请号：US12290096
申请日：2008-10-27
CPC分类号： C07K16/082 , C07K2317/20 , C07K2317/33 , G01N33/5764
摘要： Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies directed against HBV surface antigens (HBsAg) with mutations in the “a” determinant region of HBsAg.
摘要翻译： 公开了用于准确检测乙型肝炎病毒（HBV）感染的试剂，方法和免疫诊断试剂盒。 方法和试剂盒采用针对HBsAg“a”决定簇区域突变的HBV表面抗原（HBsAg）的新型兔单克隆抗体。
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8.发明申请Rabbit monoclonal antibodies to hepatitis B surface antigens and methods of using the same 有权兔单克隆抗体对乙型肝炎表面抗原及其使用方法公开(公告)号：US20090191536A1
公开(公告)日：2009-07-30
申请号：US12290096
申请日：2008-10-27
CPC分类号： C07K16/082 , C07K2317/20 , C07K2317/33 , G01N33/5764
摘要： Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies directed against HBV surface antigens (HBsAg) with mutations in the “a” determinant region of HBsAg.
摘要翻译： 公开了用于准确检测乙型肝炎病毒（HBV）感染的试剂，方法和免疫诊断试剂盒。 方法和试剂盒采用针对HBsAg“a”决定簇区域突变的HBV表面抗原（HBsAg）的新型兔单克隆抗体。
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