-
1.发明申请4-METHYL-4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXAMIDE USEFUL AS A CANNABINOID CB1 NEUTRAL ANTAGONIST 审中-公开4-甲基-4,5-二氢-1H-吡唑-3-羧酰胺作为CANNABINOID CB1中性拮抗剂有用公开(公告)号：US20110028517A1
公开(公告)日：2011-02-03
申请号：US12936698
申请日：2009-04-07
IPC分类号： A61K31/454 , C07D401/12 , C07D231/06 , A61P3/04
CPC分类号： C07D231/06
摘要： The present invention relates to 4-methyl-4,5-dihydro-1H-pyrazole-3-carboxamide, and pharmaceutically acceptable salts and solvates thereof. It further concerns pharmaceutical compositions comprising this compound as active ingredient as well as processes and intermediates for preparing this compound and compositions. The referred compound is a cannabinoid CB1 neutral antagonist useful in the prophylaxis and treatment of food intake disorders.
摘要翻译： 本发明涉及4-甲基-4,5-二氢-1H-吡唑-3-甲酰胺及其药学上可接受的盐和溶剂化物。 它还涉及包含该化合物作为活性成分的药物组合物以及用于制备该化合物和组合物的方法和中间体。 所提及的化合物是可用于预防和治疗食物摄取障碍的大麻素CB1中性拮抗剂。
-
公开(公告)号：US20100298309A1
公开(公告)日：2010-11-25
申请号：US12746635
申请日：2008-12-05
申请人： Miguel Angel Pericas-Brondo , Antoni Torrens-Jover , Félix Cuevas-Cordobes , Susana Yenes-Minguez
发明人： Miguel Angel Pericas-Brondo , Antoni Torrens-Jover , Félix Cuevas-Cordobes , Susana Yenes-Minguez
IPC分类号： A61K31/5383 , C07D498/14 , A61P29/00 , A61P37/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30 , A61P25/32 , A61P3/06 , A61P3/04 , A61P25/28 , A61P25/08 , A61P19/02 , A61P25/06 , A61P1/04 , A61P27/06
CPC分类号： C07D498/14
摘要： The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of formula (I), Wherein R1 and R2 are as defined in the description.
摘要翻译： 本发明涉及对σ-1受体具有高亲和力的新型三环三唑化合物及其制备方法，包含它们的组合物及其作为根据式（I）化合物的药物的用途，其中R1 和R2如说明书中所定义。
-
3.发明授权公开(公告)号：US07829581B2
公开(公告)日：2010-11-09
申请号：US11995708
申请日：2006-07-17
IPC分类号： A61K31/454 , A61K31/4155 , C07D401/02 , C07D403/02
CPC分类号： C07D231/06 , C07D403/12
摘要： The present invention relates to prodrugs of pyrazoline compounds of formula I, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及式I的吡唑啉化合物的前药，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。
-
4.发明申请SUBSTITUTED PYRAZOLINE COMPOUNDS WITH ACAT INHIBITION ACTIVITY, THEIR PREPARATION AND USE AS MEDICAMENTS 审中-公开具有ACAT抑制活性的取代的吡唑化合物，其制备和用作药物公开(公告)号：US20100069364A1
公开(公告)日：2010-03-18
申请号：US12523451
申请日：2008-01-17
IPC分类号： C07D231/06 , A61K31/415 , A61K31/55 , C07D401/12 , A61K31/454 , A61P3/00 , A61P3/10 , A61P3/06
CPC分类号： C07D231/06
摘要： The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals, especially in dyslipidaemia.
摘要翻译： 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物，特别是血脂异常的药物的用途。
-
5.发明申请公开(公告)号：US20080300278A1
公开(公告)日：2008-12-04
申请号：US11995708
申请日：2006-07-17
IPC分类号： A61K31/415 , A61P25/00 , A61P37/00 , A61P9/00 , A61P11/00 , A61P1/00 , A61P3/00 , A61P35/00 , C07D403/12 , C07D401/02 , C07D231/06 , A61K31/454
CPC分类号： C07D231/06 , C07D403/12
摘要： The present invention relates to prodrugs of pyrazoline compounds of formula I, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及式I的吡唑啉化合物的前药，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。
-
公开(公告)号：US08362011B2
公开(公告)日：2013-01-29
申请号：US12746635
申请日：2008-12-05
申请人： Miguel Angel Pericas-Brondo , Antoni Torrens-Jover , Félix Cuevas-Cordobes , Susana Yenes-Minguez
发明人： Miguel Angel Pericas-Brondo , Antoni Torrens-Jover , Félix Cuevas-Cordobes , Susana Yenes-Minguez
IPC分类号： C07D498/14 , A61K31/5383
CPC分类号： C07D498/14
摘要： The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of formula (I), Wherein R1 and R2 are as defined in the description.
摘要翻译： 本发明涉及对σ-1受体具有高亲和力的新型三环三唑化合物及其制备方法，包含它们的组合物及其作为根据式（I）化合物的药物的用途，其中R1 和R2如说明书中所定义。
-
7.发明授权Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators 失效磺酰胺取代的吡唑啉化合物，其制备和用作CB1调节剂公开(公告)号：US08044053B2
公开(公告)日：2011-10-25
申请号：US12445260
申请日：2007-10-10
IPC分类号： A61K31/501 , A61K31/496 , A61K31/497 , A61K31/437 , A61K31/4523 , A61K31/415 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D237/02 , C07D239/02 , C07D241/02 , C07D221/02 , C07D221/00 , C07D401/02 , C07D277/20 , C07D263/30 , C07D271/08 , C07D285/10 , C07D233/54 , C07D231/10
CPC分类号： C07D231/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代吡唑啉化合物，其制备方法，包含这些化合物的药物及其制备用于治疗人和动物的药物的用途。
-
公开(公告)号：US20100099712A1
公开(公告)日：2010-04-22
申请号：US12523394
申请日：2008-01-17
IPC分类号： A61K31/454 , C07D401/12 , C07D231/06 , A61K31/415 , A61P3/10 , A61P3/06
CPC分类号： C07D401/12 , C07D231/06
摘要： The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals, especially in dyslipidaemia.
摘要翻译： 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物，特别是血脂异常的药物的用途。
-
公开(公告)号：US20090088450A1
公开(公告)日：2009-04-02
申请号：US11658923
申请日：2005-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Albert Dordal Zueras , Lus Romero Alonso , Hulmut Henrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Albert Dordal Zueras , Lus Romero Alonso , Hulmut Henrich Buschmann
IPC分类号： A61K31/472 , C07D217/18
CPC分类号： C07D513/04 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。
-
10.发明申请Octahydropentalene-Substituted Pyrazoline Derivatives, Their Prepartion and Use as Medicaments 审中-公开八氢呋喃取代的吡唑啉衍生物，其制备和用作药物公开(公告)号：US20090054509A1
公开(公告)日：2009-02-26
申请号：US11995755
申请日：2006-07-17
IPC分类号： A61K31/4155 , C07D403/12
CPC分类号： C07D231/54 , C07D231/06 , C07D401/12 , C07D403/12 , C07D409/04
摘要： The present invention relates to octahydropentalene-substituted pyrazoline compounds of formula I, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals. (1)
摘要翻译： 本发明涉及式I的八氢蝶啶取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备治疗人和动物的药物的用途。 （1）
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.032 秒)
