公开(公告)号：US20090088450A1

公开(公告)日：2009-04-02

申请号：US11658923

申请日：2005-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Albert Dordal Zueras ,  Lus Romero Alonso ,  Hulmut Henrich Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Albert Dordal Zueras ,  Lus Romero Alonso ,  Hulmut Henrich Buschmann

IPC分类号： A61K31/472 ,  C07D217/18

CPC分类号： C07D513/04 ,  C07D217/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US07211585B2

公开(公告)日：2007-05-01

申请号：US10920738

申请日：2004-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut H. Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut H. Buschmann

IPC分类号： C07D217/00 ,  A61K31/47

CPC分类号： C07D217/04 ,  C07D401/12

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US20090163542A1

公开(公告)日：2009-06-25

申请号：US11658924

申请日：2005-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

IPC分类号： A61K31/472 ,  C07D217/04 ,  A61K31/4725 ,  A61P25/00 ,  A61P13/00 ,  A61P1/00 ,  A61P9/00 ,  C07D401/12

CPC分类号： C07D513/04 ,  C07D217/04 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US20060040978A1

公开(公告)日：2006-02-23

申请号：US10920738

申请日：2004-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

IPC分类号： C07D217/12 ,  A61K31/47 ,  C07D403/02 ,  A61K31/4709

CPC分类号： C07D217/04 ,  C07D401/12

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US08148397B2

公开(公告)日：2012-04-03

申请号：US11658923

申请日：2005-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

IPC分类号： C07D217/18 ,  A61K31/47

CPC分类号： C07D513/04 ,  C07D217/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US07211584B2

公开(公告)日：2007-05-01

申请号：US10920671

申请日：2004-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut H. Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut H. Buschmann

IPC分类号： C07D217/00 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D217/04

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US20060040977A1

公开(公告)日：2006-02-23

申请号：US10920671

申请日：2004-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

IPC分类号： C07D217/12 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D217/04

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US08188115B2

公开(公告)日：2012-05-29

申请号：US11658924

申请日：2005-08-18

申请人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Mónica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

发明人： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Mónica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Henrich Buschmann

IPC分类号： C07D217/18 ,  A61K31/47

CPC分类号： C07D513/04 ,  C07D217/04 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US20080214603A1

公开(公告)日：2008-09-04

申请号：US11813080

申请日：2005-12-27

申请人： Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

发明人： Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

IPC分类号： A61K31/4725 ,  C07D401/06 ,  A61P25/00 ,  C07D401/14

CPC分类号： C07B57/00 ,  C07B2200/07 ,  C07B2200/11 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US20090264458A1

公开(公告)日：2009-10-22

申请号：US12471128

申请日：2009-05-22

申请人： Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

发明人： Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

IPC分类号： A61K31/473 ,  A61P25/00

CPC分类号： C07D221/16 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  Y10S514/914 ,  Y10S514/923

摘要： The invention relates to compounds having pharmacological activity towards the 5-receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

摘要翻译： 本发明涉及对5-受体具有药理活性的化合物，更具体地涉及一些2,2a，4,5-四氢-1H-3-氮杂 - 苊烯取代的磺酰胺化合物，制备这些化合物的方法， 包含它们的组合物，以及它们用于治疗和/或预防其中涉及5-HT的疾病如CNS障碍的用途。